Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Conventional Adenocarcinoma In Situ
D efinition — Precursor lesion to invasive endocervical adenocarcinoma.
Clinical Features
Epidemiology
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Average age at diagnosis is 38 years.
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Human papillomavirus (HPV) related (>90%), especially types 16 and 18 in roughly equal proportion.
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About half of cases have a concurrent squamous intraepithelial lesion (SIL).
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Positive association with oral contraceptive use, although a potential mechanism is unclear.
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