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Verrucous Squamous Cell Carcinoma


D efinition —Invasive epithelial neoplasm composed of keratinocytes involving the vulva. Exhibits a distinct histology and invasive pattern that is nonmetastasizing.

Clinical Features

Epidemiology

  • Typically affects women in their seventh and eighth decades and is usually found associated with inflammatory dermatosis. May be associated with atypical verruciform hyperplasia.

  • Human papillomavirus (HPV) negative and not linked to other gynecologic (cervical) squamous lesions.

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