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Epidermodysplasia Verruciformis–Like Atypia


PITFALL

D efinition —A variant of epithelial atypia associated with gamma papillomaviruses, classically associated with epidermodysplasia verruciformis (EDV) but now appreciated in immunosuppressed (including human immunodeficiency virus [HIV]–infected) patients and involves the vulva.

Clinical Features

  • A wide age range.

    • Multiple plaque or papular to verrucous in presentation, pigmented or nonpigmented.

    • May resemble condyloma, seborrheic keratosis, or psoriasis.

  • Increased frequency in HIV-infected or immunosuppressed women.

  • Can be seen on any cutaneous or mucosal site.

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