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Classic (Usual) Vulvar Intraepithelial Neoplasia


D efinition —Classic (usual) high-grade squamous intraepithelial lesions of the vulva are defined as full-thickness or near full-thickness atypias associated with high-risk or carcinogenic human papillomavirus (HPV) infections, principally HPV 16.

Clinical Features

  • A wide age range, from second to eighth decade, predominating in the fourth and fifth decades.

  • From papular to verrucous in presentation, pigmented or nonpigmented.

  • Increased frequency in immunosuppressed women.

  • Acetowhite in the mucosal surfaces.

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