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Tumor Ablation
Techniques
Chemical Ablation with Sclerosing Agents
Sclerosing agents act by diffusion into cells and cause immediate dehydration of cytoplasm with subsequent necrosis followed by fibrosis. By entering into the circulation, these agents induce necrosis of endothelial cells and platelet aggregation, causing thrombosis.
Radiofrequency Ablation
In radiofrequency ablation (RFA), an RF probe is positioned in the patient. The probe is usually monopolar, and large grounding pads are placed on the patient's skin. An RF generator produces an oscillating current (375 to 480 kHz) causing an oscillatory movement of ions in the tissue adjacent to the probe. The oscillating movement of ions causes frictional heating, which causes protein denaturation and cellular death through thermal coagulation necrosis. A wide range of probes from different vendors are available, and probe choice depends on the shape and size of the desired ablation and operator's preference.
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