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It is estimated that around 80 million computed tomography (CT) scans of all kinds are performed in the United States each year. Almost 10% of all visits to the emergency department are for abdominal pain of a nontraumatic nature. Many of those patients undergo a CT scan of the abdomen and pelvis performed to detect or clarify their clinical findings. Since the advent of CT, exploratory surgery has become rare and the need for emergency surgery has dramatically decreased.
As with all imaging studies, one of the guiding principles in CT scanning of the abdomen and pelvis is to maximize the differences in density between tissues to best demonstrate their unique anatomy. Toward that end, CT studies make extensive use of intravenous and oral contrast agents.
CT scans can be performed with and/or without the intravenous administration of iodinated contrast material but, in general, they yield more diagnostic information that is more easily detectable when intravenous contrast can be used.
CT scans done with intravenous contrast are called contrast-enhanced or simply enhanced . Typically, the radiologist will choose the scanning parameters to optimize the CT study for the patient's particular clinical issues. For example, different rates of contrast administration and timing of the scan will allow diagnostic enhancement of hepatic vessels versus the liver parenchyma.
Although it might sound like a great idea to give everyone contrast, keep in mind that iodinated contrast can have adverse effects and produce serious reactions in susceptible individuals ( Box 14.1 ).
Intravenous contrast materials available today are nonionic, low-osmolar solutions containing a high concentration of iodine which circulate through the bloodstream, opacify those tissues and organs with high blood flow, are absorbed by x-rays (and therefore appear “whiter” on images), and are finally excreted in the urine by the kidneys.
In some patients (e.g., those with diabetes, dehydration, or multiple myeloma) who have compromised renal function evidenced by creatinine greater than 1.5 mg/dL, iodinated contrast can produce a nephrotoxic effect resulting in acute tubular necrosis. Although usually reversible, in a small number of patients with underlying renal insufficiency, renal dysfunction may permanently worsen. This effect is contrast dose-related.
Iodinated contrast agents can sometimes produce mild side-effects including a feeling of warmth, nausea and vomiting and local irritation at the site of injection, itching and hives; these side-effects usually require no treatment. Occasional idiosyncratic, allergic-like reactions may also include itching, hives, and laryngeal irritation.
Asthmatics and those with a history of severe allergies or prior reactions to intravenous contrast have a higher likelihood of contrast reactions (but still very low overall) and may benefit from steroids, diphenhydramine (Benadryl), and cimetidine (e.g., Tagamet) administered prior to and/or after injection. Prior shellfish allergy bears absolutely NO relationship to iodinated contrast reactions.
In about 0.01 to 0.04% of all patients, severe and idiosyncratic reactions to contrast can occur that can produce intense bronchospasm, laryngeal edema, circulatory collapse and, very rarely, death (1 in 200,000 to 300,000).
In patients with a history of intravenous contrast reactions, oral contrast can be safely administered without the need for premedication.
For abdominal and pelvic CT imaging, oral contrast may also be administered to define the bowel, although its use has diminished as the quality of CT images has improved. Oral contrast is usually not employed in chest CT scanning unless there is a particular question concerning the esophagus.
Orally administered contrast, frequently given in doses divided over time to allow earlier contrast to reach the colon while later contrast opacifies the stomach, is utilized for many abdominal CT scans except those performed for trauma , the stone search study , and studies specifically directed toward evaluating vascular structures such as the aorta.
One of two different types of oral contrast may be used. The most widely used is a dilute solution of barium sulfate , the same contrast agent employed in upper gastrointestinal studies and barium enemas. If there is concern for bowel perforation and the possibility that contrast may exit from the lumen of the bowel, an iodine-based, water-soluble contrast is sometimes used (e.g., Gastrografin ). Contrast may also be introduced rectally to opacify the distal colon more quickly than it would take for orally administered contrast to reach the large bowel or through a Foley catheter to quickly opacify the urinary bladder.
You will probably not be required to make the decision of when or if to use contrast as the radiologist will usually tailor the examination to best answer the clinical question being asked . That means it is always important to provide as much clinical information as possible when requesting a study.
Table 14.1 summarizes, in general, when intravenous and oral contrast are utilized for particular problems.
| IV Contrast Used | IV Contrast Usually Not Used |
|---|---|
| Chest | |
| CT-Pulmonary angiogram (CT-PA) for pulmonary embolism | Evaluation of diffuse infiltrative lung diseases using HRCT |
| Evaluation of the mediastinum or hila for mass or adenopathy | Confirmation of the presence of a nodule suspected from conventional radiographs |
| Detect aortic aneurysm or dissection | Detect pneumothorax/pneumomediastinum |
| Evaluation of blunt or penetrating trauma | Calcium scoring for the coronary arteries |
| Characterization of pleural disease (metastases, empyema) | Known allergies to contrast or renal failure |
| CT densitometry of pulmonary masses | |
| Evaluation of the coronary arteries | |
| IV Contrast Used | IV Contrast Usually Not Used |
| Abdomen and Pelvis | |
| Evaluate for the presence of and/or to characterize a mass and to stage or follow-up malignancies | CT colonography, unless staging a suspected cancer detected by colonoscopy |
| Trauma | Search for a ureteral calculus |
| Abdominal pain (e.g., appendicitis) | |
| Detect aortic aneurysm or dissection | |
| WHEN ORAL CONTRAST IS USED | |
| Most cases of nontraumatic abdominal pain | |
| Inflammatory bowel disease | |
| Abdominal or pelvic abscess | |
| Locate the site of bowel perforation, including fistulae | |
Table 14.2 outlines some of the common patient preparations that are generally suggested for a variety of imaging studies. Preparation instructions may vary depending on the facility and individual patient needs. In general, a patient is permitted to take medications with a small sip of water, even when instructions are nothing to eat or drink before the study.
| Study | Before the Order is Placed | Before the Start of the Study | After the Study is Done |
|---|---|---|---|
| CT | |||
| Head CT with or without contrast | Solicit history of previous contrast reaction | Serum creatinine may be needed before contrast injections | Nothing |
| Body CT without contrast | Nothing | No preparation needed | Nothing |
| Body CT with oral contrast and/or IV contrast | Solicit history of previous contrast reaction | Serum creatinine may be needed before contrast injections; oral contrast is given just before study | Nothing |
| US | |||
| Upper abdomen , general survey study: aorta, gall bladder, inferior vena cava, liver, pancreas, renal stenosis, retroperitoneal, spleen | Nothing | Nothing to eat or drink for several hours prior to examination | Nothing |
| Renal or kidney | Nothing | Patient may be asked to drink a prescribed amount of water to distend bladder 1 to 2 hours before procedure; patient should not empty bladder | Nothing |
| Male or female pelvis or lower abdomen; obstetric/gynecologic US | Nothing | Patient may be asked to drink a prescribed amount of water to distend bladder 1 to 2 hours before procedure; patient should not empty bladder | Nothing |
| Renal transplant ; thyroid, and vascular studies | Nothing | No preparation needed | Nothing |
| MRI | |||
| Without contrast | Solicit history of working with metal, grinding, welding or possible metal in eyes; patient may need an orbital x-ray; solicit history of pacemaker, aneurysm clips, neural stimulators, IUD, permanent makeup, cochlear implants, artificial heart valves, pregnancy, metallic fragments; claustrophobia | No preparation needed | Nothing |
| With contrast | Solicit history of working with metal, grinding, welding or possible metal in eyes; patient may need an orbital x-ray; solicit history of pacemaker, aneurysm clips, neural stimulators, IUD, permanent makeup; cochlear implants, artificial heart valves, pregnancy, metallic fragments; claustrophobia | Serum creatinine may be needed before contrast injections or in patients with renal insufficiency | Nothing |
| Barium Study | |||
| Esophagram or video fluoroscopic swallowing examination | Nothing | No preparation needed | Nothing |
| Upper gastrointestinal series /small bowel series | Nothing | Nothing to eat or drink for several hours prior to study | Nothing |
| Barium enema ; virtual colonography | Nothing | Bowel preparation to cleanse colon before study may consist of oral laxatives, suppositories, fluids | Mild laxative if desired |
| Mammography | |||
| Mammogram | Nothing | Patient should not use any deodorant, perfume, powder, ointment, or any other skin products on chest, breast, or under arms on the day of appointment | Nothing |
| Nuclear Medicine | |||
| Thyroid uptake and scan | No intravenous, iodinated contrast studies within previous 4 to 8 weeks | Stop thyroid medications or foods high in iodine content | Nothing |
| Bone density | Is the patient pregnant? | No contrast or barium studies for 48 hours prior to the procedure. No food restriction | Nothing |
| Bone scan | Is the patient pregnant? | No food restriction | Nothing |
| Cardiac treadmill and pharmacologic stress test | Is the patient pregnant? | Nothing to eat or drink for several hours prior to the examination. No caffeine several hours prior to the examination | Nothing |
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