Renal medullary carcinoma


  • Highly aggressive type of renal cell carcinoma centered in the medulla, associated with the sickle cell trait and hemoglobinopathies

Clinical features


  • Affects young adults in their second to third decades of life, with male-to-female ratio of 2:1

  • Most cases are reported in black individuals; some in Hispanic or Brazilian patients.

  • Morphologically identical tumors in patients without the sickle cell trait or hemoglobinopathies are designated as unclassified renal cancers with medullary phenotype.

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