Reference list of clinical cases covered in this book

1 Brain metastasis

a.
General approach
- i.
  Chapter 14 , Case 1: Approach to large, symptomatic brain metastasis—surgery
- ii.
  Chapter 14 , Case 2: Approach to innumerable multifocal brain metastasis—whole brain radiation
- iii.
  Chapter 14 , Case 3: Approach to multifocal brain metastasis—stereotactic radiosurgery
- iv.
  Chapter 23 , Case 2: Intracranial metastases from systemic lymphoma (hematologic malignancy)
- v.
  Chapter 23 , Case 3: Epidural metastases
b.
Surgical management
- i.
  Chapter 2 , Case 5: New symptomatic multifocal brain lesions in a known cancer patient
- ii.
  Chapter 2 , Case 7: Bony metastatic lesion with spinal cord compression
c.
Imaging
- i.
  Chapter 5 , Case 6: Dural-based metastasis
- ii.
  Chapter 6 , Case 4: Multifocal enhancing parenchymal lesion
- iii.
  Chapter 7 , Case 4: Enhancing cerebellar lesion in an adult
- iv.
  Chapter 8 , Case 6: Extradural spinal vertebral metastasis
d.
Radiation therapy
- i.
  Chapter 3 , Case 2: Stereotactic radiosurgery for a patient with a solitary brain metastasis
- ii.
  Chapter 3 , Case 3: Whole brain radiation therapy for diffuse brain metastases
e.
Special populations
- i.
  Cerebellar— Chapter 7 , Case 4: Enhancing cerebellar lesion in an adult
- ii.
  Radiation necrosis— Chapter 24 , Case 3: Radiation necrosis after radiosurgery
- iii.
  Spinal cord— Chapter 8 , Case 6: Extradural spinal vertebral metastasis

2 Ependymoma

a.
General approach
- i.
  Chapter 8 , Case 2: Spinal cord ependymoma

3 Ganglion cell tumors (ganglioglioma, gangliocytoma)

a.
Chapter 18 , Case 2: Cowden syndrome

4 Glioma: Glioblastoma

a.
General approach
- i.
  Chapter 12 , Case 2: Approach to anaplastic astrocytoma: patchy contrast enhancement in a high-grade brain lesion
- ii.
  Chapter 12 , Case 3a: Approach to glioblastoma: acute-onset neurologic deficit from a high-grade brain lesion
b.
Histopathologic classification
- i.
  Chapter 1 , Case 1: Characteristic histopathologic and molecular features of glioblastoma
c.
Imaging
- i.
  Chapter 6 , Case 1: Rim-enhancing parenchymal lesion
- ii.
  Chapter 24 , Case 1: Pseudoprogression in glioma
- iii.
  Chapter 24 , Case 2: Delayed radiation necrosis in glioma
d.
Surgical management
- i.
  Chapter 2 , Case 2: New symptomatic supratentorial high-grade lesion
- ii.
  Chapter 2 , Case 3: Recurrent unresectable supratentorial high-grade glioma
e.
Radiation therapy
- i.
  Chapter 3 , Case 1: Radiation therapy for high-grade glioma
f.
Chemotherapy
- i.
  Chapter 4 , Case 4: Newly diagnosed glioblastoma
g.
Recurrence
- i.
  Chapter 4 , Case 6: Recurrent high-grade glioma
- ii.
  Chapter 12 , Case 3d: Recurrent disease and end-of-life care in high-grade glioma
h.
Treatment complications
- i.
  Chapter 12 , Case 3b: Seizures, edema, and posttreatment neurological complications in high-grade glioma
- ii.
  Chapter 12 , Case 3c: Venous thrombosis, Pneumocystis , steroid myopathy, and non-neurological complications of glioma
- iii.
  Chapter 19 , Case 1: Neurological complications (e.g., cerebral edema, epilepsy, stroke, hydrocephalus, syndrome of inappropriate antidiuretic hormone [SIADH])
- iv.
  Chapter 19 , Case 2: Non-neurological treatment complications (e.g., venous thromboembolism, hypercoagulability, neurocognitive dysfunction, fatigue, sleep dysfunction)
i.
Special populations
- i.
  Elderly— Chapter 4 , Case 5: Glioblastoma in the elderly
- ii.
  End-of-life care— Chapter 12 , Case 3d: Recurrent disease and end-of-life care in high-grade glioma
- iii.
  Lynch syndrome— Chapter 18 , Case 4: Lynch syndrome
- iv.
  Radiation-induced glioblastoma— Chapter 26 , Case 6: Radiation-induced glioma/glioblastoma

5 Glioma: Anaplastic gliomas

a.
General approach
- i.
  Chapter 12 , Case 1: Progression from low-grade to anaplastic oligodendroglioma
b.
Histopathologic classification
- i.
  Chapter 1 , Case 4: Histopathologic and molecular findings for WHO grade 3 anaplastic astrocytoma
c.
Imaging
- i.
  Chapter 6 , Case 1: Rim-enhancing parenchymal lesion
- ii.
  Chapter 24 , Case 1: Pseudoprogression in glioma
- iii.
  Chapter 24 , Case 2: Delayed radiation necrosis in glioma
d.
Radiation therapy
- i.
  Chapter 3 , Case 1: Radiation therapy for high-grade glioma
e.
Chemotherapy
- i.
  Chapter 4 , Case 1: Anaplastic 1p19q co-deleted oligodendrogliomas
- ii.
  Chapter 4 , Case 2: Anaplastic non–co-deleted astrocytomas
f.
Recurrence
- i.
  Chapter 4 , Case 6: Recurrent high-grade glioma
g.
Treatment complications
- i.
  Chapter 12 , Case 3b: Seizures, edema, and posttreatment neurological complications in high-grade glioma
- ii.
  Chapter 12 , Case 3c: Venous thrombosis, Pneumocystis , steroid myopathy, and non-neurological complications of glioma
- iii.
  Chapter 19 , Case 1: Direct effects of brain tumors (e.g., cerebral edema, epilepsy, stroke, hydrocephalus, SIADH)
- iv.
  Chapter 19 , Case 2: Non-neurological treatment complications (e.g., venous thromboembolism, hypercoagulability, neurocognitive dysfunction, fatigue, sleep dysfunction)

6 Glioma: Low-grade gliomas

a.
General approach
- i.
  Chapter 11 , Teaching point #1: How to determine an integrated histologic and molecular diagnosis of low-grade glioma
- ii.
  Chapter 11 , Teaching point #2: How to differentiate high-risk and low-risk low-grade glioma
- iii.
  Chapter 11 , Teaching point #3: How to determine whether to observe or initiate treatment at diagnosis of low-grade glioma
- iv.
  Chapter 11 , Teaching point #4: How to determine a patient-specific treatment plan for low-grade glioma
- v.
  Chapter 11 , Teaching Point #5: How to select a patient-specific chemotherapy regimen for low-grade glioma
b.
Histopathologic classification
- i.
  Chapter 1 , Case 3: Use of genomic profiling to establish a diagnosis of WHO grade 2 astrocytoma
- ii.
  Chapter 1 , Case 2: Use of molecular testing to define the diagnosis of WHO grade 2 oligodendroglioma
c.
Imaging
- i.
  Chapter 6 , Case 2: Non-enhancing parenchymal lesion
d.
Chemotherapy
- i.
  Chapter 4 , Case 3: Low-grade gliomas
e.
Special populations
- i.
  H3K27M mutant glioma— Chapter 12 , Final section after cases: Approach to H3K27M mutant diffuse midline gliomas
- ii.
  IDH mutant— Chapter 11 , Clinical pearl 1: Approach to IDH -mutant low-grade gliomas
- iii.
  IDH wild type— Chapter 11 , Clinical pearl 2: Approach to IDH wild-type low-grade gliomas
- iv.
  Neurologic complications— Chapter 11 , Clinical pearl 4: Approach to the diagnosis and management of neurological complications for low-grade gliomas
- v.
  Seizure management— Chapter 11 , Clinical pearl 3: Approach to seizure management in low-grade gliomas

7 Hemangioblastoma

a.
General approach
- i.
  Chapter 8 , Case 3: Spinal cord hemangioblastoma in a patient with von Hippel Lindau disease
- ii.
  Chapter 18 , Case 1: von Hippel Lindau disease

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1

Brain metastasis

2

Ependymoma

3

Ganglion cell tumors (ganglioglioma, gangliocytoma)

4

Glioma: Glioblastoma

5

Glioma: Anaplastic gliomas

6

Glioma: Low-grade gliomas

7

Hemangioblastoma

8

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