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Quick Evidence Synopsis
Title:
Efficacy and Safety of Vaccines for Dengue
Date completed:
April 22, 2015
Authors:
Tatyana A. Shamliyan, MD, MS and David R. Goldmann, MD
Clinical question:
What are the efficacy and safety of dengue vaccine in children and adults?
What does the evidence conclude?
| Intervention | Quality of Evidence a | Balance between Benefits and Harms b |
|---|---|---|
| Three injections of recombinant live attenuated tetravalent dengue vaccine (CYD-TDV) | Moderate | Likely to be beneficial for children Unknown effectiveness for adults |
a Quality of evidence scale (GRADE): high, moderate, low, and very low. For more information on the GRADE rating system, see http://www.gradeworkinggroup.org/index.htm .
b The Guideline Elements Model, http://gem.med.yale.edu/default.htm .
What are the parameters of our evidence search?
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