Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Objective Structured Clinical Examinations (OSCEs) are commonly used as part of medical school assessments. They allow assessment of clinical performance and important skills which are difficult to assess in written examinations. These include key domains such as clinical skills, communication skills, judgement, leadership and professionalism.
In many countries over the past decade, OSCEs have moved away from a rigid ‘checklist’-based scoring system to assessment by global competency scoring, usually assessing different domains at each station. The practice cases given here do include a checklist as part of the answer scheme because they are designed to allow readers to practice OSCE stations with peers, with one taking the part of the candidate and the other the examiner and/or model patient.
Ms AB, 32 years old, and Mr TB, 34 years old, have attended the clinic with a 3-year history of not being able to conceive. Please take a concise history.
What initial investigations would you request?
Please interpret these results. What is the diagnosis? What treatment options may be available?
See Chapter 5 .
You have never been pregnant before (para 0+0). You have a history of regular periods, 5 days in 28, which are not heavy or particularly painful. You do not experience bleeding between your periods. Your last smear was 1 year ago and was normal. You have previously used the combined oral contraceptive pill but stopped this 3 years ago. You and your partner have been actively trying for a pregnancy for 3 years. You do not have any history of abnormal discharge and, as far as you know, have never been diagnosed with a pelvic infection. Your past medical history includes asthma only. Your drug history includes use of a salbutamol inhaler only. You are a non-smoker and drink 4 units alcohol per week and take regular exercise. You are a primary school teacher.
You have no children from previous relationships. Your past medical history includes type 1 diabetes. You have no history of testicular trauma, surgery nor infection. You smoke 20 cigarettes a day and drink 8 units of alcohol per week. You work in the construction industry.
Please provide the following investigation results:
Investigations:
Rubella IgG antibodies: | Negative |
Day 21 Progesterone: (normal >10 ng/mL) | 35 ng/mL |
Day 3 LH, FSH, Estradiol levels | All normal |
Semen Analysis | ||
Normal Value | Result | |
Volume (mL) | >1.5 | 2 |
Vitality (%) | >58 | 65 |
Count (million/mL) | 15 | 0.5 |
Morphologically normal (%) | 4 | 5 |
Motility (progressive) (%) | >32 | 40 |
Motility (total) (%) | >40 | 50 |
A history should include:
A pregnancy history from Ms AB and whether Mr TB has any children from other relationships
Menstrual history, including pattern and amount and last menstrual history. A history of oligomenorrhoea or amenorrhoea will point towards an anovulatory cause.
Use of contraception
Length of time trying to conceive
Pelvic pain and dyspareunia, which may point towards endometriosis
Abnormal vaginal discharge or a previous history of pelvic infection
Past medical history
Drug history
Smoking status
Lifestyle factors, including occupation
Psycho-sexual problems
Initial investigations should include:
LH, FSH, estradiol, Anti-Mullerian Hormone
Rubella serology
D21 serum progesterone (test of ovulation)
Hysterosalpingogram (HSG; test of tubal patency)
Semen analysis.
Other options: Pelvic ultrasound, laparoscopy, hysteroscopy, prolactin, thyroid function tests, testosterone, sex hormone binding globulin, sperm function, mixed agglutination; anti-sperm antibodies may be relevant based on initial investigation results and specific history.
Male factor infertility/oligospermia.
In vitro fertilization (IVF) with intracytoplasmic sperm injection. In this scenario, an HSG is not required, as the requirement for IVF means the fallopian tubes are ‘bypassed’. An ultrasound is required to look for hydrosalpinx, because the presence of hydrosalpinges reduces the success of each IVF cycle.
See Chapter 5 .
Ms CB has presented with bleeding at 10 weeks of pregnancy. An ultrasound demonstrates: (1) an intrauterine gestation sac, (2) a fetal pole, (3) crown-rump length of 9 mm and (4) the absence of fetal heart activity. She has been told that, sadly, she has experienced a miscarriage. Please speak to her regarding her options at this point.
See Chapters 6 .
Possible questions for you to ask:
Why has this happened? Is this really unusual?
What are the risks of management? Will there be any impact on my future fertility?
Will I be able to get pregnant in the future? When can I try for another pregnancy?
Are there any investigations I should have? Is there any treatment available?
It is important to be understanding and sympathetic. It is a good idea to start by recognising that this is a distressing situation.
The incidence of miscarriage is about 20%, increasing significantly with age.
A woman may ask why this has happened. It is helpful to be reassuring that the woman’s actions have not caused a miscarriage. In at least 50% of cases, no reason can be found. Some 50% of cases appear to be caused by chromosomal abnormalities within the fertilized egg. Rarer causes include autoimmune conditions, such as anti-phospholipid syndrome or poorly controlled diabetes. It is unclear whether structural abnormalities of the uterus play a part. Smoking cessation advice should always be given.
Options for management include:
Expectant management (a ‘wait-and-see’ approach)
Medical management of miscarriage, with synthetic prostaglandins (misoprostol)
Surgical management of miscarriage, usually under general anaesthetic whereby a suction curette is used to aspirate the contents of the uterus. Cervical preparation with misoprostol is usually used beforehand.
Risks include:
Retained products of conception
Infection–women should be specifically told to report whether they have any symptoms, such as fever, heavy bleeding, pain, offensive discharge
Haemorrhage and, in rare cases, blood transfusion
In the case of surgical management, trauma to the genital tract, including perforation of the uterus and cervical trauma. In the case of perforation, further surgery, such as laparoscopy or laparotomy, may be required to diagnose and treat any complication, such as bowel or bladder injury.
In terms of impact on future fertility, there is no clear evidence that either method impacts on future fertility. Asherman syndrome is a rare condition which has been described after uterine evacuation whereby adhesions and scarring of the endometrium cause secondary amenorrhoea.
If asked when it is okay to become pregnant again, it is appropriate to say that it is usually when a woman feels emotionally and physically ready.
Investigations for rarer causes of miscarriage are usually performed only in cases of recurrent miscarriage, which is defined as 3 or more miscarriges. Only a small percentage have an identifiable and treatable cause. However, even in these cases, the chance of a successful future pregnancy is 60% to 75%. Counselling and reassurance are currently the mainstays of treatment, although this is an area of ongoing research. Unproven treatments should be avoided.
See Chapters 6 .
Ms EF has arrived in the emergency department with a 1-day history of vaginal spotting and severe abdominal pain. She had an episode of fainting while in the waiting room. You are the on-call emergency department doctor. Please discuss with the examiner how you will assess her.
See Chapters 6 and 44 .
Encourage a systematic approach. Provide information when specifically asked. The woman is lying still on a hospital trolley. She looks pale. She is conscious but not answering questions clearly and keeps saying she feels really unwell. No one is available to provide a collateral history.
Airway is patent.
Respiratory rate (RR) is 12, oxygen saturation 98%, chest is clear on auscultation.
Heart rate (HR) is 120 beats per minute, regular. Heart sounds pure. Cool peripheries, peripheral capillary refill 4 seconds, central capillary refill less than 2 seconds. Blood pressure (BP) 110/65 mmHg. Ask what actions would you take at this point. Expect intravenous (IV) access; bloods, including full blood count (FBC) and blood group; and fluid replacement with crystalloid.
Blood glucose 6.3, Glasgow Coma Scale (GCS) 15.
Abdomen tender and peritonitic. Pregnancy test is positive. Left shoulder pain.
Ask about differential diagnoses.
Ask initial management.
Ask whom they would like to contact for assistance. Ask them to make the phone call.
Ask about further management.
In an emergency situation, it is helpful to take a structured ABCDE approach.
An ectopic pregnancy should always be considered in collapse of a woman of childbearing age.
Airway
RR, oxygen saturations, auscultate chest
HR, BP and capillary refill. Actions: gain IV access (large bore, 2 cannulas), take bloods tests including FBC, renal function, and blood group. Start IV fluid circulating volume resuscitation with crystalloid fluid.
Blood sugar and GCS.
Expose, palpate abdomen, looking for evidence of bleeding (external and concealed), shoulder pain.
A urinary catheter should be inserted to obtain urine for a urinalysis, perform a urinary pregnancy test and guide fluid replacement.
A speculum should be inserted to look for vaginal bleeding or an open cervical os, which may suggest miscarriage.
Young healthy women typically compensate well in the early stages of ongoing bleeding. By the time their vital signs are abnormal, they are very unwell. Therefore, a normal BP in this case is not reassuring. This woman is showing signs of haemorrhagic shock, including tachycardia, dizziness and cool peripheries. A peritonitic abdomen and positive pregnancy test point towards an ectopic pregnancy test being the most likely cause. It is important to recognise the seriousness of the situation and escalate appropriately. An appropriate person to contact on this occasion would be the on-call gynaecology registrar or consultant.
Good communication is key and could take an SBAR approach. For example:
Situation —I’m phoning with regard to a 23-year-old woman who I suspect has an ectopic pregnancy. She has signs of severe hypovolaemia and has collapsed once already.
Background —She has a short history of abdominal pain, vaginal bleeding and dizziness.
Assessment —On examination, she is tachycardic with cool peripheries. Her abdomen is peritonitic. Her pregnancy test is positive.
Recommendation —I have gained IV access and taken bloods, including blood group, and started IV fluids. I would like you to come and review her with a view to urgent surgery.
A pelvic ultrasound would be useful in determining the diagnosis but should not delay management, which, in this case, will be transfer to theatre for surgery. A FAST (Focused Assessment with Sonography for Trauma) scan in the Emergency Department may be useful to look for the presence of free fluid in the abdomen, which in this context, is intraperitoneal blood.
See Chapters 6 and 44 .
Ms GH is a 49-year-old solicitor who has been referred to gynaecology triage by her general practitioner (GP) with heavy vaginal bleeding. Please take an appropriate history.
What investigations would be appropriate at this point?
What is your differential diagnosis?
See Chapter 7 .
You have a 6-week history of constant bleeding. Your GP started a course of tranexamic acid and norethisterone 2 weeks ago, which helped while you took it, but as soon as you stopped this, the heavy bleeding came back.
Prior to this, your periods were regular, bleeding for 5 days in 28. They have been heavier over the last year and have become significantly more painful. You have had time off work because off this, which is very unusual for you. You are para 2+0 having had 2 vaginal births in the past. You have not had any postcoital bleeding and do not have any pain with sexual intercourse. Your smears have always been normal in the past, although it is 10 years since you had one. You do not use contraception, as your husband has had a vasectomy. You have had no new sexual partners.
You have been feeling very run down recently. Your past medical history includes hypothyroidism, for which you take thyroxine. You are allergic to penicillin. Your mother had a hysterectomy in her 50s, although you are not sure what this was for.
A gynaecology history should include:
Menstrual history, including whether periods are regular or irregular, length, heaviness and any associated pain. Irregular periods may suggest an anovulatory disorder. Painful periods raise the possibility of endometriosis or adenomyosis. Heaviness can be subjective—it is useful to ask about impact on quality of life, as what may be acceptable for one woman could be unbearable for another.
Intermenstrual bleeding, which may point towards structural abnormality
Postcoital bleeding, which might suggest cervical pathology, or infection.
Cervical screening history—in particular, abnormal tests or missed tests
Sexual history—a new partner may increase the risk of sexually transmitted infection
Dyspareunia—deep dyspareunia may suggest endometriosis, or infection.
Pelvic pain, whether cyclical or non-cyclical
Pregnancy history, future fertility wishes, date of last period and considering the possibility of the woman being pregnant and unaware of it
Contraception, including iatrogenic causes. For instance, sudden cessation of a progestogen is likely to cause a withdrawal bleed.
Any easy bruising/frequent nose bleeds etc – which might point towards a coagulation disorder. Any fatigue or light-headedness, which may suggest anaemia.
Past medical history
Current medication, allergies
Relevant family history
Investigations performed to date
Symptoms related to menopause.
Given her age (>45 years) and recent change in bleeding pattern, it is necessary to investigate further, including endometrial sampling. In a younger woman, when history and examination do not suggest pathology, a trial of treatment is an appropriate first-line step. However, investigations should be initiated in the event of treatment failure.
Investigations should include:
FBC and haematinics (ferritin, iron stores) to look for anaemia
Examination and pelvic swabs, including endocervical swab
An ultrasound to look for structural abnormalities, such as a submucosal fibroid or polyp
An endometrial biopsy to look for endometrial hyperplasia or cancer
A hysteroscopy, depending on initial investigations, for structural abnormalities in the uterus.
A differential for possible causes of heavy menstrual bleeding includes:
Endometrial and cervical polyps
Adenomyosis
Fibroids, particularly submucus and intramural
Malignancy, including cervical and endometrial
Coagulopathy
Iatrogenic related to contraception or exogenous hormones
Ovulatory dysfunction, or approaching menopause.
Endometrial origin (when other causes excluded).
This is often the conclusion of an OSCE question. Sometimes, the questions are designed to test how systematic your approach is and how wide your differential diagnoses are rather than to specifically test whether you reached the correct diagnosis.
See Chapters 2 and 7 .
IH is a 28-year-old para 1 who has been experiencing heavy periods. She has had a normal examination, recently had negative vaginal swabs, a normal pelvic ultrasound and has a normal cervical smear history. She would like to discuss treatment options. She feels that her periods are ruining her life.
Please discuss this with her.
See Chapter 7 .
If asked, you are not currently trying for another pregnancy but are not sure if your family is complete.
You would specifically like more information on intrauterine contraception, including side effects and risks.
Medical options for managing heavy periods include:
The levonorgestrel-releasing intrauterine system (LNG-IUS)—also offers contraception for up to 5 years and 95% reduction in blood loss at 12 months, with many women experiencing amenorrhoea. Side effects include irregular bleeding, particularly in the first 3 to 6 months, and expulsion rate is about 5%. There is a small risk of perforating the uterus on insertion. There is an increased risk of pelvic infection. If pregnancy does occur, there is an increased risk of ectopic pregnancy. However, overall lower numbers of pregnancies also means fewer ectopic pregnancies.
Tranexamic acid and mefenamic acid—tranexamic acid is an antifibrinolytic. It can reduce blood loss by about 50%. Side effects include gastric upset and tinnitus. It is not suitable in individuals at high risk of venous thromboembolism (VTE). Mefenamic acid is a non-steroidal anti-inflammatory drug. It reduces blood loss by 25% and acts as a painkiller. Side effects include headache, dizziness and gastric upset. This is the best option for women trying to conceive, as other medical options also act as contraceptives.
Oral contraception—can be taken in a cyclical fashion to cause a withdrawal bleed, or ‘back to back’. There is an approximate 50% reduction in blood loss. Not always appropriate for those at high risk for venous thrombosis aged over 35 years and experiencing persistent migraine with aura. The progesterone-only pill may be suitable for some women who cannot take the combined contraception pill.
Cyclical norethisterone—may be used to regulate an irregular cycle, although it does not appear to reduce blood loss.
Injected long-acting progestogens—depot-injectable progestogen frequently results in amenorrhoea when taken for an extended period. Side effects include irregular bleeding initially, bloating, breast tenderness, headaches, increased appetite and skin changes. It can sometimes take 12 to 18 months for periods and fertility to resume once the injections are stopped.
GnRH analogues which cause amenorrhoea by pituitary downregulation would not be an appropriate first-line treatment in a 28-year-old.
Both endometrial ablation and hysterectomy are inappropriate in this case, as IH wishes to preserve her future fertility.
JK is a 21-year-old woman who presents to the emergency department with severe abdominal pain. Her initial systemic observations are normal and a urinary pregnant test is negative. Please take an appropriate history.
What would you look for on examination?
Please suggest a differential diagnosis. What initial investigations would you send?
See Chapters 8 and 44 .
JK has had severe 9/10 pain in her left lower abdomen for the last 6 hours. It is constant and sharp. This was a sudden, almost instant onset and associated with vomiting initially. She has taken co-codamol with no improvement. The pain is particularly bad when she moves or tries to go the toilet. It does not radiate anywhere. There is no change in bowel habit. There are no urinary symptoms.
Her last menstrual period was 3 weeks ago; her periods are usually light and regular. She reports no intermenstrual or postcoital bleeding. She has a new sexual partner whom she has been dating for 3 months. They are using condoms. She reports no new vaginal discharge. She had surgical termination of pregnancy 2 years ago but no other pregnancies. Her past medical history includes a previous laparoscopic appendicectomy. She takes no regular medications and is allergic to latex.
Vital signs are normal. On general inspection, JK looks very uncomfortable and is struggling to mobilise with the pain. She has tenderness and guarding in the left iliac fossa. A speculum demonstrates a normal vulva, vagina and cervix. There is cervical excitation and a mass is felt in the left adnexa.
When asking about acute pelvic pain, it is necessary to ask about site, onset, characteristics, radiation, severity, exacerbating and relieving factors, relationship to menstrual cycle and analgesia requirement. A sudden onset of severe pain may point towards an ovarian cyst accident (ovarian torsion, ovarian cyst rupture or haemorrhage into a cyst).
Associated gastrointestinal symptoms should be sought. Vomiting and nausea may be a feature of ovarian torsion; gastrointestinal upset can be a symptom of a ruptured ectopic pregnancy. These symptoms may also point towards a non-gynaecological cause, such as appendicitis or diverticulitis. Associated urinary symptoms such as dysuria or frequency may point towards a UTI, while haematuria or loin to groin pain may suggest renal colic.
A detailed menstrual history is important, including frequency and character, any intermenstrual bleeding, or postcoital bleeding.
A sexual history should be taken. Ask about changes in vaginal discharge. It is necessary to ask about deep and superficial dyspareunia. In addition, ask for specifics regarding contraception and smear history.
Examination should include general inspection—is the woman able to move and talk without significant discomfort?
An abdominal examination would include inspection of the abdomen for distension and masses, palpation for tenderness, rebound tenderness, guarding and auscultation for bowel sounds.
A speculum and bimanual examination should be carried out, looking specifically for cervical excitation and adnexal masses.
A differential diagnosis might include:
Ovarian torsion
Ovarian cyst accident
Pelvic inflammatory disease.
Appropriate investigations would include:
Urinalysis, urinary pregnancy test
Bloods, including FBC and C-reactive protein (CRP) to assess markers of infection
High vaginal and endocervical swabs
Pelvic ultrasound to look for evidence of ovarian cysts and tubo-ovarian abscess. An ovary with a large cyst is more likely to tort, and sometimes colour Doppler can be performed to give information on the likelihood of torsion.
In cases of severe, unresolved pain, a diagnostic laparoscopy may be appropriate. If torsion is suspected, expediting surgical management will relieve symptoms and give the best chance of salvaging healthy ovarian tissue in the case of torsion.
See Chapters 8 and 44 .
LM, a 25-year-old, returns to your clinic for a follow-up appointment. She has recently had a diagnostic laparoscopy due to chronic pelvic pain. This has demonstrated superficial endometriosis on the left pelvic side wall and in the pouch of Douglas, which has been excised. She has been told she has endometriosis but does not know what it is. Please discuss the operation findings with her.
See Chapter 8 .
Questions you ask could include:
What is endometriosis?
What causes it?
Can it be cured?
I have heard that you cannot get pregnant if you have endometriosis. Is this true?
How can endometriosis be treated? Will I have to have more surgery?
A question like this tests your communication skills. It is important to explore what the woman already understands and what she is concerned about. An explanation should be clear and should avoid using medical jargon when possible. It may be helpful to look at patient information leaflets or websites to get an idea for how to explain medical ideas simply.
Endometriosis is the presence of endometrial-like tissue outside of the uterus. This is usually in the pelvis, such as the uterosacral ligaments or pelvic peritoneum but more rarely can affect more distant sites. These tissues respond to hormones in the same way that endometrium does, causing inflammation and pain. The incidence is reported to be between 4% and 43%. It is unclear what causes it—theories include retrograde menstruation and metaplasia. It is difficult to know why it affects some women and not others, although there may be genetic or immunological factors. Typically, it causes pain just before or during a period, although some women also experience chronic pain unrelated to their cycle. Other symptoms include pain during sex, pain during ovulation, pain on defecation, cyclical or menstrual symptoms and subfertility. There is a poor correlation between the extent of disease found at laparoscopy or on imaging and the severity of the symptoms. There is an association with subfertility, but it is not the case that all women with endometriosis will have problems conceiving.
Management options can be split into analgesia, ovulation suppression or surgery. Ovulation suppression may be with combined or progesterone-only contraceptives, or with LNG-IUS. GnRH analogues are second line and usually limited to 4 to 6 months, with add-back hormone replacement. Surgery can include treatment of superficial disease, a pelvic clearance or treatment of deep infiltrating disease in a specialist centre.
There is an association with subfertility. Treatment of minimal to mild disease does appear to improve fertility, but the role in moderate to severe endometriosis is less clear. Removal of large endometriotic cysts may improve fertility. Assisted reproductive techniques may be required more often than in the non-endometriosis population.
See Chapter 8 .
Mrs ML is a 65-year-old woman who has been experiencing urinary incontinence. Please take an appropriate history.
Please suggest possible management options.
See Chapter 11 .
You have been experiencing incontinence for several years. You find that you need to go to the toilet up to 10 times daily, including many times overnight and sometimes will not make it to the toilet in time. You have not noticed any leakage of urine when coughing or sneezing.
You are a para 4, having had 4 vaginal births. Your favourite drink is tea and you do not tend to drink anything else. When out for the day, you will not drink anything at all to avoid needing the toilet. You are a smoker and do not drink alcohol. You have not been aware of a prolapse.
This is having a huge impact on your confidence and quality of life.
Become a Clinical Tree membership for Full access and enjoy Unlimited articles
If you are a member. Log in here