Myxoid cyst


Evidence Levels: A Double-blind study B Clinical trial ≥ 20 subjects C Clinical trial < 20 subjects D Series ≥ 5 subjects E Anecdotal case reports

Myxoid cysts are also known as digital mucus cysts or pseudocysts and represent a ganglion of the distal interphalangeal joint. They arise in different forms in soft tissues, typically above or distal to the distal interphalangeal joint. The most common presentation is as a translucent nodule on the dorsum of the digit. Additional patterns of presentation include as a pseudofibroma emerging between the proximal nailfold and dorsal aspect of the nail plate, or as a tumor beneath the nail matrix causing a red lunula, increased transverse curvature of the nail, and sometimes its disintegration.

Management Strategy

Myxoid cysts contain gelatinous material that has escaped from the distal interphalangeal joint. Treatment can involve evacuation combined with measures to prevent further escape from the joint. Simple drainage through an incision can achieve the first, but normally there is recurrence within a few weeks. Measures to prevent the further accumulation of fluid are directed at reducing joint pathology or blocking the pathway of escape of fluid. The first category includes the use of injected triamcinolone, which might reduce synovial inflammation and the pressure of fluid within the joint, and surgery for osteophytes. Osteophytes appear to weaken the joint capsule and possibly contribute to joint pathology and synovial fluid production. Their removal is associated with resolution of the myxoid cyst but at the risk of alteration of joint function.

Blockage of the path of fluid escape is achieved by a range of traumatic and scarring procedures. The challenge is to produce an effective scar over the joint without excess morbidity or a long-term nail dystrophy.

A practical compromise of morbidity, complexity of treatment, and efficacy is to employ cryosurgery in the first instance. This is best used with a distal block using lidocaine or bupivacaine. The cyst is then incised and drained. Two freezes of between 10 and 20 seconds with liquid nitrogen are given, with a complete thaw in between. Over the next 2 weeks the wound is dressed. This results in success in about 50% of cases involving fingers. Those that fail can be retreated in the same way or proceed to surgery. Morbidity is least when there is precise surgery to the path of fluid escape. This can be identified and then ligatured following methylene blue injection into the joint and then raising a flap in a distal-to-proximal path, containing the cyst in the roof of the flap. In many instances it is possible to gain the same benefit without preliminary dye injection. The flap is sutured back in place, and success is reported as 94% in the fingers. In some instances, patient preference or medical considerations may mean that surgery is the first-line therapy.

Specific Investigations

  • Transillumination

  • Pricking and expression of gelatinous material

  • Ultrasound

  • Magnetic resonance imaging (MRI)

Transillumination is a useful clinical aid. Dermoscopy can be used, but rarely improves on transillumination. Where there is diagnostic doubt, simple incision can be helpful to demonstrate the gelatinous material. Alternatively, high-resolution ultrasound or MRI can be employed. The first can only help define whether the structure is cystic or not. The latter provides better anatomic definition and in over 80% of cases allows location of the pedicle communicating between the cyst and joint. Plain X-ray may reveal osteophytes of osteoarthritis, but this will not usually alter treatment.

Dermoscopic features of digital mucous cysts: a study of 23 cases

Chae JB, Ohn J, Mun JH. J Dermatol 2017 Nov; 44(11): 1309–12.

Benign tumors and pseudotumors of the nail: a novel application of sonography

Wortsman X, Wortsman J, Soto R, et al. J Ultrasound Med 2010; 29: 803–16.

MR imaging of digital mucoid cysts

Drapé JL, Idy Peretti I, Goettmann S. Radiology 1996; 200: 531–6.

First-Line Therapies

  • Cryosurgery

  • B

  • Puncture

  • D

  • Laser therapy

  • C

  • Sclerosant

  • C

Myxoid cysts of the finger: treatment by liquid nitrogen spray cryosurgery

Dawber RPR, Sonnex T, Leonard J, et al. Clin Exp Dermatol 1983; 8: 153–7.

Fourteen patients were treated with two 30-second freezes and no evacuation of the cyst. Follow-up was between 14 and 40 months, with an 86% cure rate. One patient had a significant nail dystrophy as a long-term complication.

Removal of the overlying cyst or evacuation of the contents might reduce the duration of cryosurgery needed. Longer freeze times increase morbidity and risk of scarring.

Specific indications for cryosurgery of the nail unit

Kuflik EG. J Dermatol Surg Oncol 1992; 18: 702–6.

Forty-nine patients were treated with a range of single cryosurgical doses, from 20 to 30 seconds using open spray, and 30 to 40 seconds using the cryoprobe. This was combined with curettage in 23 patients and simple deroofing in the remainder. There was resolution in 63% over the follow-up period of 1–60 months.

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