Multifocal Choroiditis with Panuveitis


History of Present Illness

A 25-year-old woman with no past medical history and a long-standing history of myopia presents for the first time to the eye clinic complaining of distorted vision in her right eye (OD). She first noticed that her vision was a little blurry about a month ago, which also coincided with more floaters than she is used to. She had assumed that these symptoms were insignificant and would resolve, but then 2 weeks later she noticed a grayed-out area of vision paracentrally OD, so she decided to present to the eye clinic.

Exam
OD OS
Visual acuity 20/40 20/20
Intraocular pressure (IOP) 18 19
Sclera/conjunctiva White and quiet White and quiet
Cornea Clear Clear
Anterior chamber (AC) 2+ white cells Deep and quiet
1+ flare
Iris Unremarkable Unremarkable
Lens Clear Clear
Anterior vitreous 2+ white cells Clear

Dilated Fundus Examination (DFE) (See Fig. 28.1 )
Nerve Cup-to-disc (c/d) 0.1, peripapillary
atrophy
Macula Lacquer cracks
Vessels Normal caliber and course
Periphery Unremarkable

Fig. 28.1, Color fundus photograph of the right eye shows lacquer cracks and a small submacular hemorrhage. There were no peripheral lesions.

Questions to Ask

  • Have you noticed anything in the left eye (OS)?

  • Have you had any recent illnesses or hospitalizations?

  • Are you having or have you recently had any other symptoms in the rest of your body, such as joint pains, new rashes, breathing problems, problems with bowel movements, or oral or genital ulcers?

  • Have you had any tick bites recently?

  • Have you ever traveled outside the country?

  • Have you had any trauma or surgery to the eye?

  • Do you use injection drugs?

  • Do you practice safe sex?

  • What is your glasses prescription?

The patient answers no to the first seven questions. She has always used barrier protection during sex. She hands over her glasses, and the Rx is −9.00 +0.75×180 OD, −8.50 +0.50×145 OS.

Fluorescein angiography (FA) and optical coherence tomography (OCT) were pursued to further investigate the cause of metamorphopsia and subretinal hemorrhage ( Fig. 28.2 ).

Fig. 28.2, Fluorescein angiogram of the right eye shows early hyperfluorescence in the area of the lacquer crack, as well as multiple hypofluorescent spots in areas where there were no funduscopically visible lesions ( left panel, early frame ), suggestive of occult choroiditis. In the late frame ( right panel ), the area of early, discrete hyperfluorescence has increased in size and intensity, suggestive of choroidal neovascularization. OCT OD ( not shown ) confirmed the presence of shallow subretinal fluid.

Assessment

  • Panuveitis with occult multifocal choroiditis (MFCPU) by angiography OD

  • Choroidal neovascularization OD

  • High myopia OU with secondary lacquer cracks

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