Introduction

The term interventional MRI is used to describe the use of magnetic resonance imaging (MRI) for rapid guidance and/or monitoring of a minimally invasive diagnosis or therapy where the entire procedure is interactively performed within an interventional MRI suite in a manner that is equivalent to standard fluoroscopic or ultrasound (US)-guided procedures. The term interventional MRI itself is relatively new as a description of a full clinical service of MRI-guided interventions integrated within the daily practice of interventional radiology. The idea of adapting MRI for interventional procedure guidance, however, dates back to the mid-1980s shortly after the introduction of MRI as a diagnostic imaging modality.

Continued growth of the field of interventional MRI (iMRI) is marked by the increasing number of academic institutions with added iMRI capabilities, the growing diversity of iMRI applications adopted at these institutions, and the expanding technologic innovations that back this growth.

iMRI Suite Setup

An iMRI suite is an interventional procedure room equivalent to other medical procedure rooms where the main interventional equipment may consist of an x-ray fluoroscopy unit, a computed tomography (CT) scanner, a US scanner, an endoscopy unit, and so forth. In this case the room activity revolves around an MRI scanner. This arrangement is a hybrid design that has to fulfill the requirements of both a regular diagnostic MRI scanner and an interventional radiology suite. Specifically the fundamental requirements for an iMRI suite include:

  • (1)

    Adequate access to the patient within the scanner to perform an interventional procedure. Access to the patient is restricted within the regular narrow, long bores of standard scanners. Interventional solutions include use of an open-configuration scanner or adopting other workflow solutions as described in this chapter.

  • (2)

    Availability of MRI-compatible anesthesia equipment, monitoring tools, and interventional devices. These are currently available from several vendors on a commercial basis.

  • (3)

    Ability to achieve proper draping and to ensure a completely sterile field during interventions. This is a more challenging job compared to the customary draping of flat surfaces during traditional x-ray fluoroscopy, CT, or US-guided interventions.

  • (4)

    Ability to implement rapid pulse sequences with reasonable signal-to-noise ratio to ensure adequate visualization of the interventional device and timely updates of its location to achieve safe device placement.

  • (5)

    Ability to operate the scanner and to review updated images at the patient's bedside without having to remove the operator's hand at any time from the interventional setting.

iMRI System Design and Workflow Solutions

Designing an MRI scanner for interventional purposes is a technically and logistically complex endeavor. On the technical side, the environment suitable for adequate access to the patient and comfortable application of anesthesia equipment and monitoring devices is basically the opposite of that “closed magnet” environment suitable for producing high-quality diagnostic MRI scans. Logistically there will probably be a need—at least for the foreseeable future—to use an iMRI scanner for routine diagnostic imaging to maximize the revenue of the scanner and support the associated interventional programs. Several interventional solutions have been implemented over the past years that included both magnet design and workflow/combined-suite solutions ( Fig. 66-1 ).

FIG 66-1, Various magnet design and workflow/combined-suite solutions for iMRI.

Magnet Design Solutions

The one recognized limitation the leaders of the field of interventional MRI agree on is that the ultimate interventional MRI scanner is yet to be built. The General Electric Medical Systems magnet with the double-doughnut design (Signa SP system, Milwaukee, Wisconsin, USA) was the world's first MRI scanner designed and produced for the sole purpose of MRI-guided interventions. This design is based on a 0.5-tesla (T) superconducting magnet where the central segment has been removed from the cylindrical system, leaving two “doughnuts,” one on each side, allowing access to the patient from the sides and top at the isocenter of the imaging system. The system was first installed at the Brigham and Women's Hospital in Boston in the mid-1990s and promised a prosperous future for this field. Unfortunately that era of development was not the prime time for a dedicated iMRI scanner, and a sufficient clinical practice was never generated to support commercialization of this scanner. In fact the last one of these scanners operating today is currently installed at Shiga University of Medical Science, Otsu, Shiga, Japan, awaiting the formal label of a “historic item.” The rise and fall of the double-doughnut system has managed to keep GE furthest away from iMRI applications, with other vendors stepping in to offer some interventional solutions, albeit modestly. With all lessons learned, these solutions have been centered on constructing scanners with more open configurations to allow better patient access for interventions while maintaining a platform that is fully operational for standard diagnostic imaging. In-room radiofrequency-shielded liquid crystal display (LCD) monitors have also been made available to immediately review reconstructed images at the scanner side and operate the scanner from within the room. Vendors also have provided some software solutions for device guidance (e.g., the Integrated Front End [IFE] program from Siemens) and treatment monitoring. Vendors are, however, still reluctant to reengage in designing a full-scale interventional scanner or to respond to the need for more involved hardware modifications geared toward satisfying interventional needs. In the current iMRI practice, magnet design solutions are centered on the use of open-configuration cylindrical superconducting systems and biplanar lower-field-strength open systems designed to accommodate claustrophobic and obese patients and to allow MRI-guided interventions.

Workflow/Combined-Suite Solutions

This group represents a growing sector of iMRI solutions and is more suitable when the intervention is not intended to be solely conducted within the MRI environment but rather when MRI is needed as a part of a procedure, such as to obtain updated information on organ shift, confirm extent of a resection, or monitor effect of therapy or drug delivery. The primary concept in these solutions is related to meeting space requirements and installation specifications and cost. Interactive MRI-guided device placement is usually not feasible with this setup. Examples of these workflow/combined-suite solutions follow.

Hybrid MRI/Fluoroscopy Suites.

In this arrangement a conventional x-ray fluoroscopy unit is installed within the same MRI suite. Patients are positioned on the same procedure table throughout the entire intervention while the table is moved between the two systems on a track or wheels. The value of these suites is highlighted during cardiovascular catheter intervention procedures where vascular access and catheter navigation is still more straightforward under standard fluoroscopic guidance, whereas MRI provides state-of-the-art additions to these procedures, such as plaque burden imaging and characterization within the vessel wall, imaging perivascular soft tissues for procedure complications (e.g., infracted territory, hemorrhage, etc.), or accurately locating catheter tips in relation to cardiac chambers and assessing the effect of radiofrequency ablation (RFA) during electrophysiology procedures.

IMRIS System.

This system is primarily geared toward facilitating intraoperative imaging and has become a popular component of modern neurosurgery suites in recent years. Surgeons operate using their standard operating table and operative techniques. When imaging is needed during the course of surgery to quantify the extent of brain shift following dural incision or to evaluate the extent of resection, the MRI unit is moved on giant ceiling-mounted tracks to cover the patient's head.

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