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Spread of primary tumor to spine, where bone destruction exceeds bone production
Multiple osteolytic lesions in spine
Compression fracture with bowing of posterior cortex, osteolysis extending into neural arch, extraosseous soft tissue
Lesion distribution proportional to red marrow (lumbar > thoracic > cervical)
Radiography requires 50-70% bone destruction and tumor size > 1 cm for detection
Bone scan can give false-negatives with aggressively lytic tumor or with very small lesions
Hematopoietic malignancy
Benign (osteoporotic) compression fracture
Schmorl node
Normal heterogeneous marrow
Spondylodiscitis
Spine is most common site of osseous metastases
Spine metastases found in 5-10% of cancer patients
Common primaries causing osteolytic metastases
Breast, lung, renal most common
Other: Thyroid, GI tract, ovarian, melanoma
Pain: Progressive axial, referred, or radicular
Compression fractures common
Epidural tumor extension may cause neurologic dysfunction
Cord compression in 5% of adults with systemic cancers (70% solitary, 30% multiple sites)
Osteolytic metastases
Spread of primary tumor to spine, where bone destruction exceeds bone production
Best diagnostic clue
Multiple lytic lesions in spine
Compression fracture with bowing of posterior cortex, osteolysis extending into neural arch, extraosseous soft tissue
Location
Vertebral body and posterior elements
Lesion distribution proportional to red marrow (lumbar > thoracic > cervical)
Size
Any size
Morphology
Typically round (due to centrifugal growth) destruction of bone
Radiography
Requires 50-70% bone destruction and tumor size > 1 cm for detection
AP: Absent (“missing”) pedicle, ± paraspinous soft tissue mass
Lateral: Destroyed posterior cortical line
Plain films detect level of neural compression < 25%
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