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D efinition —Human papillomavirus (HPV)–related proliferation of the vaginal mucosa.
Patients present at a slightly older age than those with cervical dysplasia, with the majority presenting around 40 years of age.
Sixty-five percent of patients with vaginal intraepithelial lesion (VAIL) have concurrent or prior cervical dysplasia.
HPV is responsible for the majority of lesions, and predisposing factors include previous cervical intraepithelial neoplasia (CIN), history of previous hysterectomy for dysplasia, history of local radiation therapy, and immunosuppression.
In patients at risk, speculum examination with the intent of discovery of vaginal lesions leads to their discovery in most cases.
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