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Lichen Simplex Chronicus and Prurigo Nodularis
D efinition —A cutaneous reaction related to scratching, often superimposed on other dermatoses.
Clinical Features
Epidemiology
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Lichen simplex chronicus (LSC) is not a distinctive disease but a clinical and pathologic response to repeated physical trauma such as rubbing or scratching.
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Often superimposed on eczematous dermatitis.
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Also seen in patients who habitually scratch.
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In the absence of other pathology, it is termed neurodermatitis.
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More commonly seen at perimenopause and postmenopause, but can present at any age.
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Associations have been made with both classic and differentiated vulvar intraepithelial neoplasia (VIN) and certain human leukocyte antigen (HLA) haplotypes.
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