High-Grade Serous Tubal Intraepithelial Neoplasia (Serous Tubal Intraepithelial Carcinoma)

Epidemiology

• Serous tubal intraepithelial carcinoma (STIC) is rare, found in less than 1 : 1000 routine salpingectomies. It is found in from 1% to 12% of tubes removed during risk reduction salpingo-oophorectomy (RRSO) for inherited BRCA1 or BRCA2 mutations, the percentages increase with increasing patient age. It is discovered in up to 50% of fallopian tubes of women with high-grade pelvic serous carcinoma. It can be associated with, and presumably preceded by, a benign clonal expansion of secretory cells with p53 mutations (p53 signatures). Depending on the study, up to 30% of women with a carcinoma arising in the fallopian tube (with STIC) harbor a BRCA1 or BRCA2 mutation.