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The pathogenesis of obstructive sleep apnea (OSA) is complex and involves many anatomic and physiologic factors. The Fujita system for classifying the level of airway obstruction is often employed as a diagnostic tool. Level 1 indicates obstruction at the retropalatal/oropharyngeal level area. Level 2 indicates obstruction at the retropalatal/oropharyngeal and retroglossal/hypopharyngeal levels. Level 3 indicates obstruction at the retroglossal/hypopharyngeal area only. One of the major contributors to airway collapse in OSA is loss of muscular activity or tone to the pharyngeal dilators during sleep. The genioglossus muscle is one of the major pharyngeal dilators and the primary muscle allowing tongue protrusion. The muscle is attached to the genial tubercles located on the lingual aspect of the anterior mandible. Thus, its influence on obstruction at the retroglossal/hypopharyngeal level in OSA cannot be understated. For this reason, the genioglossus advancement (GA) procedure, with all of its variations and modifications, was developed.
The original GA procedure was described in a case report detailing a “high” sliding advancement genioplasty osteotomy, which was secured in place via wire osteosynthesis. A limitation of this procedure is failure to capture the entire genial tubercle complex, resulting in suboptimal airway improvement. Riley et al. then modified this procedure to incorporate the entire genioglossus muscle insertion at the genial tubercles using a mortised sliding advancement genioplasty, but the procedure led to higher risks of pathologic fracture of the mandible. Subsequent modifications to reduce fracture risk included a rectangular bicortical osteotomy of the anterior mandible around the region of the genial tubercles, with subsequent advancement and 90-degree rotation of the attachments, followed by rigid fixation. Lewis and colleagues later described a trephine osteotomy and rigid fixation system for advancing the genial tubercle/genioglossus muscles using the Stryker Leibinger genioglossus bone advancement technique (GBAT) system (Stryker Leibinger, Kalamazoo, Michigan). There have been subsequent modifications and variations to this same theme during the past two decades. With many of these procedures, a simultaneous infrahyoid myotomy and hyoid suspension were often performed (see Chapter 37 ).
Patient selection is important to optimize GA surgical results. Patients with mild-moderate OSA and collapse in the retroglossal/hypopharyngeal region may be most likely to respond.
GA can be combined with other surgical treatments such as uvulopalatopharyngoplasty (UPPP), bilateral sagittal split advancement osteotomies of the mandible, and bimaxillary advancement osteotomies.
Advanced imaging using cone beam computed tomography (CBCT) technology combined with computer-assisted virtual surgical planning and custom three-dimensional (3D) printed marking and positioning guides can minimize operating time and improve the precision of with which the genial tubercles are captured and advanced.
OSA history
OSA diagnosis and severity
Sleep-related symptoms
Medical comorbidities (e.g., hypertension, heart disease)
Prior OSA medical therapy (e.g., continuous positive airway pressure [CPAP], bilevel positive airway pressure [BIPAP], oral appliance)
Prior OSA surgical therapy (e.g., UPPP)
Comorbid sleep medicine disorders (e.g., insomnia)
Past medical history
Past surgical history
Family history
Social history, particularly alcohol and tobacco use
Medications, especially anticoagulants or herbal products
General —A general examination of the patient is important to assess his or her overall health and development. It is also important to consider his or her body habitus or body mass index (BMI), as patients with high weights or BMI are less likely to benefit from a GA alone.
Head and Neck —It is important to carefully examine the patient’s head and neck to look for any signs of skeletal hypoplasia that could be contributing to the patient’s obstructive symptoms. Those individuals that could benefit most from GA often present with mandibular hypoplasia and/or microgenia. Mentalis strain and the competence of the lips are also important; often, skeletal Class II patients have lip incompetence and exhibit mentalis strain when trying to close their lips. Neck circumference and hyoid position are two other factors to consider, as larger, thicker necks are associated with higher risk of OSA, and a low-set hyoid may indicate the same.
Nasal airway —It is important to thoroughly examine the nasal cavity for any evidence of obstruction that could be resolved via nasal surgery alone or with a combination of nasal surgery and surgery, affecting another level of obstruction.
Oral cavity and oropharynx —This is a very important examination because it gives valuable information regarding the size of the tongue and its contributions to the patient’s obstructive symptoms, the volume of soft tissue comprising the soft palate that may be amenable to UPPP, and the size of the tonsils, which may contribute to the symptoms. It is important to note that the presence or absence of periodontal disease could increase the risk of fracture if a GA is performed. The amount and health of the keratinized tissue located buccal to the mandibular incisors are important during the postoperative course, as the incision, closure, and any subsequent scarring are located adjacent to this area, and contractures may result in unaesthetic gingival recession around the mandibular incisors.
Panoramic Radiograph —To visualize the periodontal tissues, dentition, height of the anterior mandible, mental foramina, inferior alveolar nerve canal, and temporomandibular joints
Lateral Cephalometric Radiograph —Evaluate the presence and severity of maxillary, mandibular, and genial hypoplasia, all of which can contribute to various levels of obstruction in the airway during sleep.
CBCT Scan or Maxillofacial CT Scan —Maxillofacial CT scans, and more recently CBCT scans, have been incorporated into the planning stages of various sleep surgeries, including GA. This is a proven technology that has been used for years and has been shown to have a high degree of accuracy. CBCT scans are advantageous in that they provide useful data regarding the volumetric aspects of the airway. The technology also facilitates the ability to make precise measurements to aid in planning osteotomies, avoiding critical structures such as the mental foramina, and to locate crucial aspects of the patient’s anatomy, such as the genial tubercles in this case. In addition, surgical models of the patient’s anatomy can be printed and studied along with the fabrication of surgical stents and guides to assist with various osteotomies to be certain that critical structures are included or avoided and that the specific surgical goal that was planned is accomplished. Postoperatively, the patient can be scanned again, and volumetric data can be generated about the increase in airway size and capacity.
Mild-moderate OSA with failure or inadequate adherence with medical therapy:
Retrolingual or hypopharyngeal location of collapse
Fujita type 2 or 3
Microgenia or mandibular hypoplasia. GA for these patients may have both airway and aesthetic benefits.
Significant medical comorbidities prohibiting operative intervention
Severe obesity likely to decrease GA effectiveness and increase perioperative risk
Airway obstruction localized to Fujita Level 1
Severe OSA
Severe periodontal disease
Patients concerned about transient or permanent V3 paresthesia
Discontinue any antiplatelet and anticoagulant medications if possible.
Oxymetazoline nasal spray prior to the induction of nasal endotracheal anesthesia.
Consider perioperative course of high-dose steroids to minimize postsurgical edema of the floor of the mouth, tongue, and airway.
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