The comprehensive eye examination involves a series of tests evaluating vision, as well as the general health of the eyes, and includes screening for ophthalmologic diseases or ocular manifestation of systemic diseases.

Anatomy and Physiology

The eye is the sensory organ that transmits visual stimuli to the brain for interpretation ( Fig. 12.1 ). It occupies the orbital cavity; only its anterior aspect is exposed. The eye itself is a direct embryologic extension of the brain.

FIG. 12.1, Anatomy of the human eye.

There are four rectus and two oblique muscles attached to the eye ( Fig. 12.2 ). Cranial nerve (CN) II, the optic nerve, connects the eye to the brain.

Physical Examination Components

  • 1.

    Measure visual acuity, noting:

    • Near vision

    • Distant vision

    • Peripheral vision

  • 2.

    Inspect the eyebrows for

    • Hair texture

    • Size

    • Extension to temporal canthus

  • 3.

    Inspect the orbital area for

    • Edema

    • Redundant tissues or edema

    • Lesions

  • 4.

    Inspect the eyelids for

    • Ability to open wide and close completely

    • Eyelash position

    • Ptosis

    • Fasciculations or tremors

    • Flakiness

    • Redness

    • Swelling

  • 5.

    Palpate the eyelids for nodules

  • 6.

    Inspect the orbits

  • 7.

    Pull down the lower lids and inspect palpebral conjunctivae, bulbar conjunctiva, and sclerae for

    • Color

    • Discharge

    • Lacrimal gland punctum

    • Pterygium

  • 8.

    Inspect the external eyes for

    • Corneal clarity

    • Corneal sensitivity

    • Corneal arcus

    • Color of irides

    • Pupillary size and shape

    • Pupillary response to light and accommodation, afferent pupillary defect

    • Nystagmus

  • 9.

    Palpate the lacrimal gland in the superior temporal orbital rim

  • 10.

    Evaluate muscle balance and movement of eyes

    • Corneal light reflex

    • Cover-uncover test

    • Six cardinal fields of gaze

  • 11.

    Ophthalmoscopic examination

    • Lens clarity

    • Retinal color and lesions

    • Characteristics of blood vessels

    • Disc characteristics

    • Macula characteristics

    • Depth of anterior chamber

FIG. 12.2, Extraocular muscles of the eye as viewed from above.

External Eye

The external eye is composed of the eyelid, conjunctiva, lacrimal gland, eye muscles, and the bony orbit. The orbit also contains fat, blood vessels, nerves, and supporting connective tissue (see Fig. 12.1 ).

Eyelid

The eyelid is composed of skin, striated muscle, the tarsal plate, and conjunctivae. Meibomian glands in the eyelid provide oils to the tear film. The tarsus provides a skeleton for the eyelid. The eyelid distributes tears over the surface of the eye, limits the amount of light entering it, and protects the eye from foreign bodies. Eyelashes extend from the anterior border of each lid.

Conjunctiva

The conjunctiva is a clear, thin mucous membrane. The palpebral conjunctiva coats the inside of the eyelids. The bulbar (or ocular) conjunctiva covers the outer surface of the eye. The bulbar conjunctiva protects the anterior surface of the eye with the exception of the cornea and the surface of the eyelid in contact with the globe.

Lacrimal Gland

The lacrimal gland is located in the temporal region of the superior eyelid and produces tears that moisten the eye ( Fig. 12.3 ). Tears flow over the cornea and drain via the canaliculi to the lacrimal sac and duct and then into the nasal meatus.

FIG. 12.3, Important landmarks of the left external eye.

Eye Muscles

Each eye is moved by six muscles—the superior, inferior, medial, and lateral rectus muscles and the superior and inferior oblique muscles (see Figs. 12.2 and 12.22 ). They are innervated by CNs III (oculomotor), IV (trochlear), and VI (abducens). The oculomotor nerve controls the levator palpebrae superioris (which elevates and retracts the upper eyelid) and all extraocular muscles, except for the superior oblique muscle and the lateral rectus muscle. The superior oblique is the only muscle innervated by the trochlear nerve and the lateral rectus muscle is the only muscle innervated by the abducens nerve.

Internal Eye

The internal structures of the eye are composed of three separate layers. The outer wall of the eye is composed of the sclera posteriorly and the cornea anteriorly. The middle layer, or uvea, consists of the choroid posteriorly and the ciliary body and iris anteriorly. The inner layer of nerve fibers is the retina (see Fig. 12.1 ).

Sclera

The sclera is the dense, avascular structure that appears anteriorly as the white of the eye. It physically supports the internal structure of the eye.

Cornea

The cornea constitutes the anterior sixth of the globe and is continuous with the sclera. It is optically clear, has rich sensory innervation, and is avascular. It is a major part of the refractive power of the eye.

Uvea

The iris, ciliary body, and choroids comprise the uveal tract (see Fig. 12.1 ). The iris is a circular, contractile muscular disc containing pigment cells that produce the color of the eye. The central aperture of the iris is the pupil, through which light travels to the retina. By dilating and contracting, the iris controls the amount of light reaching the retina. The ciliary body produces the aqueous humor (fluid that circulates between the lens and cornea) and contains the muscles controlling accommodation. The choroid is a pigmented, richly vascular layer that supplies oxygen to the outer layer of the retina.

Lens

The lens is a biconvex, transparent structure located immediately behind the iris (see Fig. 12.1 ). It is supported circumferentially by fibers arising from the ciliary body. The lens is highly elastic, and contraction or relaxation of the ciliary body changes its thickness, thereby permitting images from varied distances to be focused on the retina.

Retina

The retina is the sensory network of the eye. Photoreceptors and neurons transform light impulses into electrical impulses, which are transmitted through the optic nerve, optic tract, and optic radiation to the visual cortex in the brain and then to interpretation in the cerebral cortex. The optic nerve passes through the optic foramen along with the ophthalmic artery and vein. The optic nerve communicates with the brain and the autonomic nervous system of the eye. Accurate binocular vision is achieved when an image is fused on the retina by the cornea and the lens. An object may be perceived in each visual cortex, even when one eye is covered, if the light impulse is cast on both the temporal and the nasal retina. Fibers located on the nasal retina decussate in the optic chiasm ( Fig. 12.4 ). Accurate binocular vision also requires the synchronous functioning of the extraocular muscles.

FIG. 12.4, The optic chiasm.

Major landmarks of the retina include the optic disc, from which the optic nerve originates, together with the central retinal artery and vein. The macula, or fovea, is the site of central vision (see Fig. 12.1 ).

Infants and Children

The eyes develop during the first 8 weeks of gestation and may become malformed due to prenatal drug and alcohol exposure or infection. The development of vision, which is dependent on maturation of the nervous system, occurs over a longer period ( Table 12.1 ). Term infants are hyperopic, with a visual acuity of less than 20/400 (see Visual Acuity Testing). Although peripheral vision is fully developed at birth, central vision matures later. One of the earliest visual responses is the infant’s regard for the mother’s face. By 2 to 3 weeks of age, many infants will show an interest in large objects. Lacrimal drainage is complete at the time of term birth, and by 2 to 3 weeks of age, the lacrimal gland begins producing a full volume of tears. By 3 to 4 months of age, binocular vision development is complete. By 6 months, vision has developed sufficiently so that the infant can differentiate colors.

TABLE 12.1
Chronology of Visual Development
Age Levels of Development
Birth Awareness of light and dark; infant closes eyelids in bright light
Visual acuity 20/670 (6/200)
Neonatal Rudimentary fixation on near objects, able to regard mother’s face
2 weeks Transitory fixation, usually monocular at a distance of roughly three feet
Follows large, conspicuously moving objects
4 weeks Visual acuity 20/550 (6/160)
Moving objects evoke binocular fixation briefly
6 weeks Follows moving objects with jerky eye movements
8 weeks Visual following now achieved by a combination of head and eye movements
Visual acuity 20/150 (6/45)
12 weeks Visual acuity 20/230 (6/70) Enjoys light objects and bright colors
Beginning of depth perception
Fusion of images begins to appear
16 weeks Visual acuity 20/60 (6/18)
Fixates immediately on moving target, visually pursues dropped toy
20 weeks Shows interest in stimuli more than three feet away
Retrieves a dropped 1-inch cube
Can maintain voluntary fixation of stationary object even in the presence of competing moving stimulus
24 weeks Visual acuity reaches healthy adult level 20/100 (6/6) (6/30)
Can maintain voluntary fixation of stationary object even in the presence of competing moving stimulus
Hand-eye coordination appearing
Will fixate on a string
Binocular fixation clearly established
26 weeks Marked interest in tiny objects
28 weeks Tilts head backward to gaze up
40 weeks Discriminates simple geometric forms (squares and circles)
Looks at pictures with interest
1 year Visual acuity 20/60 (6/20)
Convergence well established
Localization in distance crude—runs into large objects
3 years Visual acuity 20/50 (6/15)

Young children become less hyperopic with growth. The globe of the eye grows as the child’s head and brain grow, and adult visual acuity is achieved at about 4 years of age.

Pregnant Patients

The eyes undergo several changes during pregnancy because of physiologic and hormonal adaptations. These changes can result in hypersensitivity and can change the refractive power of the eye. Tears contain an increased level of lysozyme, resulting in a greasy sensation and perhaps blurred vision for contact lens wearers. Diabetic retinopathy may worsen significantly. Mild corneal edema and thickening associated with blurred vision may occur, especially in the third trimester. Intraocular pressure falls most notably during the latter half of pregnancy.

Older Adults

The major physiologic eye change that occurs with aging is a progressive weakening of accommodation (focusing power) known as presbyopia. In general, by 45 years of age, the lens becomes more rigid, and the ciliary muscle becomes weaker. The lens also continues to form fibers throughout life. Old fibers are compressed centrally, forming a denser central region that may cause loss of clarity of the lens and contribute to cataract formation (clouding of the lens that can become partially or totally opaque; see Fig. 12.41 ). See Risk Factors, “Cataract Formation.”

Risk Factors
Cataract Formation

  • Family history of cataracts

  • Steroid medication use

  • Exposure to ultraviolet light

  • Cigarette smoking

  • Diabetes mellitus

  • Aging

Review of Related History

For each of the symptoms or conditions discussed in this section, targeted topics to include in the history of the present illness are listed. Responses to questions about these topics provide clues for focusing the physical examination and the development of an appropriate diagnostic evaluation. Questions regarding medication use (prescription and over-the-counter preparations) as well as complementary and alternative therapies are relevant for each.

History of Present Illness

Red Eye (Presence of Conjunctival Injection or Redness)

  • Difficulty with vision: one or both eyes, corrected by lenses

  • Recent injury or foreign bodies; sleeping in contact lenses

  • Pain: with or without loss of vision, in or around the eye, superficial or deep, insidious or abrupt in onset; burning, itching, or nonspecific uncomfortable or gritty sensation

  • History of swelling, infections, or eye surgery

  • History of recent illness or similar symptoms in the household

  • Allergies: type, seasonal, associated symptoms

  • Eye secretions: color (clear or yellow), consistency (watery or purulent), duration, tears that run down the face, decreased tear formation (with sensation of gritty eyes)

  • Medications: eye drops or ointments, antibiotics, artificial tears, mydriatics; glaucoma medications, antioxidant vitamins (to prevent macular degeneration), steroids (which promote cataract formation)

Vision Problem(s)

  • Eyelids: recurrent hordeola (stye; acute infection of sebaceous glands of Zeis), chalazion (chronic blockage of meibomian gland), ptosis of the lids so that they interfere with vision (unilateral or bilateral), growths or masses, itching

  • Double vision: oculomotor, trochlear, or abducens nerve deficit

  • Unilateral or bilateral, corrected by lenses, involving near or distant vision, primarily central or peripheral, transient or sustained

  • Cataracts (bilateral or unilateral), types (e.g., infantile, senile, diabetic, traumatic, surgical treatment)

  • Adequacy of color vision

  • Presence of halos around lights, floaters, or diplopia (when one eye is covered or when both eyes are open)

  • Sudden loss of vision or portion of visual field: transient ischemic attack, stroke, amaurosis fugax (painless temporary loss of vision in one or both eyes)

  • Trauma: to the eye as a whole or a specific structure (e.g., cornea) or supporting structures (e.g., the floor of the orbit); events surrounding the trauma; efforts at correction and degree of success

Think About It

A person presents with an isolated unilateral sixth nerve (abducens nerve) palsy. The inability to adduct the affected eye causes horizontal binocular diplopia that resolves on closing the affected eye. Consider micro-vascular disease, the most common cause. Contributing factors include diabetes, hypertension, and hypercholesterolemia. Typically in these cases, the palsy resolves within 3 months. Further workup may be pursued if symptoms do not resolve or worsen in 3 months.

Past Medical History

  • Eye surgery: condition requiring surgery, cataract removal, laser vision correction, date of surgery, outcome

  • Chronic illness that may affect eyes or vision: glaucoma, diabetes, atherosclerotic cardiovascular disease (ASCVD), hypertension, thyroid dysfunction, autoimmune diseases, human immunodeficiency virus (HIV), inflammatory bowel diseases

  • Medications: steroids, hydroxychloroquine, antihistamines, antidepressants, antipsychotics, antiarrhythmics, immunosuppressants, glaucoma eye drops, beta-blockers

Family History

  • Retinoblastoma (often an autosomal dominant disorder)

  • Glaucoma, macular degeneration, diabetes, hypertension, or other diseases that may affect vision or eye health

  • Cataracts

  • Color blindness, retinal detachment, retinitis pigmentosa, or allergies affecting the eye

  • Nearsightedness, farsightedness, strabismus, or amblyopia

Personal and Social History

  • Employment: exposure to irritating gases, chemicals, foreign bodies, or high-speed machinery

  • Activities: participation in sporting activities that might endanger the eye (e.g., boxing, lacrosse, hockey, basketball, football, paintball, martial arts, rifle shooting, racquetball, fencing, motorcycle riding)

  • Use of protective devices during work or activities that might endanger the eye

  • Corrective lenses: type (glasses or contact lenses), when last changed, how long worn, adequacy of corrected vision; methods of cleaning and storage or frequency of disposal, insertion and removal procedures of contact lenses; sleeping with contact lenses in

  • Date of last eye examination, history of corrective surgery, e.g., LASIK (laser-assisted in situ keratomileusis)

  • History of cigarette smoking (a risk factor for cataract formation, glaucoma, macular degeneration, thyroid eye disease)

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