Physical Address
304 North Cardinal St.
Dorchester Center, MA 02124
Embryonic testicular regression (Vanishing testis syndrome)
Definition
-
A developmental anomaly in which one or both testicles vanish during embryogenesis in patients with XY karyotype
Clinical features
Epidemiology
-
Usually sporadic with rare familial instances with recessive trait
-
Unclear etiology, possibly regression of the testes in utero due to a genetic mutation, a teratogen, intrinsic gonadal disorders, infection, trauma, late antenatal or perinatal vascular thrombosis, torsion, or prenatal hormone induced atrophy resulting from overproduction of androgens
-
Incidence of monorchidism: 1/5000 males; 4.5% in patients with cryptorchidism; 40% when the testis is impalpable on physical examination
-
Incidence of bilateral anorchidism: 1/20,000 males
You're Reading a Preview
Become a Clinical Tree membership for Full access and enjoy Unlimited articles
If you are a member. Log in here
