Eales Disease


History of Present Illness

A 33-year-old male, born in Sri Lanka, who has lived in Switzerland since 2013, presents himself at the eye clinic complaining of vision loss for 4 months in his left eye (OS). He just returned from a holiday in Sri Lanka. When the symptoms started, he noticed blurred vision, followed by floaters and a feeling of pressure in his OS. At the time he was using a steroid cream due to psoriasis-like lesions on his extremities. He denied other health issues and had no systemic medications. In the past few weeks he was seen by two other ophthalmologists—the first prescribed a new pair of glasses, which did not help; the second diagnosed a vitreous hemorrhage in the OS.

Exam
OD OS
Visual acuity 20/20 20/30
Intraocular pressure (IOP) 14 15
Sclera/conjunctiva White and quiet White and quiet
Cornea Arcus superior Arcus superior
Anterior chamber (AC) Deep, cells 0.5+ Deep, cells 0.5+
Iris Unremarkable Unremarkable
Lens Clear Clear

The vitreous showed 1+ vitreous cells right eye (OD) and vitreous hemorrhage OS. Funduscopy OD revealed intraretinal dot hemorrhages and pronounced neovascularization elsewhere (NVE). OS showed vitreous hemorrhage, intraretinal hemorrhage, and NVE ( Fig. 26.1A and B , Fig. 26.2A and B , and Fig. 26.3A and B ).

Fig. 26.1, (A and B) The vitreous showed 1+ vitreous cells OD and vitreous hemorrhage OS. Funduscopy OD revealed intraretinal dot hemorrhages and pronounced neovascularization elsewhere (NVE). OS showed vitreous hemorrhage, intraretinal hemorrhage, and NVE.

Fig. 26.2, (A and B) Wide field fluorescein angiography OU confirms NVE and depicts peripheral retinal vascular leakage and nonperfusion. There is phlebitis OS > OD and blockage due to vitreous hemorrhage OS.

Fig. 26.3, (A and B) The montage wide field swept source/optical coherence tomography (OCT)/angiography color-coded retina slabs highlight the vascular abnormalities, including intraretinal microvascular anomalies (IRMAS), areas of flow voids, and retinal neovascularization. Image artifacts OS are due to vitreous hemorrhage.

Questions to Ask

  • Have you ever had aphthous ulcers, joint pain, or thrombosis?

  • Is there any history of eye illnesses in the family?

  • Were you born preterm?

  • Have you had radiation in the past?

  • Do you have diabetes?

  • Were you ever diagnosed with sickle cell disease or anemia?

The patient denies all of these questions.

Assessment

  • Occlusive vasculitis with neovascularization and vitreous hemorrhage OS > OD of unknown origin

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