Cytomegalovirus (CMV) Anterior Uveitis


History of Present Illness (HPI)

A 58-year-old man with no significant past medical history presents for follow-up of anterior uveitis in the left eye (OS). He has been seen multiple times by outside ophthalmologists and has been on topical steroids for 2 months. He reports he has never been able to get off the steroids completely. He has had testing for an underlying cause of uveitis, all of which have been negative, including human immunodeficiency virus (HIV), syphilis, purified protein derivative (PPD), Lyme serologies, HLA-B27, angiotensin-converting enzyme (ACE), lysozyme, and a chest computed tomography (CT) scan to assess for pulmonary sarcoidosis. He notes some blurred vision OS, which has waxed and waned since the onset of the uveitis but has never been normal.

Ocular medications:

  • Prednisolone acetate 1% three times a day (TID) OS

  • Timolol twice a day (BID) OS

    Fig. 6.1, Color slit lamp photograph of the left eye shows sectoral atrophy of the inferior iris.

Exam
OD OS
Vision 20/20 20/25−
IOP 14 24
Lids and lashes: Normal Normal
Sclera/conjunctiva: White and quiet Trace injection
Cornea: Clear Clear, a few fine keratic precipitates (KP)
Anterior chamber (AC): Deep and quiet 1+ cells
Iris: Flat See Fig. 6.1
Lens: Clear Clear
Anterior vitreous: Clear Clear

Dilated Fundus Examination (DFE)
Nerve: Normal, cup-to-disc (c/d) 0.4 Normal, c/d 0.5
Macula: Good foveal reflex Good foveal reflex
Vessels: Normal caliber and course Normal caliber and course
Periphery: Unremarkable Unremarkable

Further Questions to Ask

  • Have you ever had trauma to the eye? Have you ever had a hyphema/bleeding inside the eye?

  • Have you ever had shingles on your face or head?

He answers no to all questions.

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