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Conventional Squamous Cell Carcinoma
D efinition —A malignant neoplasm of the cervix comprised of squamous epithelial cells. Variants include large-cell keratinizing, large-cell nonkeratinizing, and small-cell nonkeratinizing squamous cell carcinoma (SCC), as well as papillary SCC.
Clinical Features
Epidemiology
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Associated with high-risk human papillomavirus (HPV) infection and preexisting cervical intraepithelial neoplasia.
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The progression rate from a high-grade squamous intraepithelial lesion to invasive squamous cell carcinoma in a patient undergoing close follow-up is less than 1%.
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The majority of patients that present with SCC are those who have not undergone regular screening with Pap smears.
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Historically the incidence is dropping, and a larger percentage are presenting at lower stage. In 2010, 11,800 women developed cervical cancer in the United States and 3,900 died of the disease.
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