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Respiratory tract symptoms, including cough, wheeze, and stridor, occur frequently or persist for long periods in a substantial number of children; other children have persistent or recurring lung infiltrates with or without symptoms. Determining the cause of these chronic findings can be difficult because symptoms can be caused by a close succession of unrelated acute respiratory tract infections or by a single pathophysiologic process. Specific and easily performed diagnostic tests do not exist for many acute and chronic respiratory conditions. Pressure from the affected child's family for a quick remedy because of concern over symptoms related to breathing may complicate diagnostic and therapeutic efforts.
A systematic approach to the diagnosis and treatment of these children consists of assessing whether the symptoms are the manifestation of a minor problem or a life-threatening process; determining the most likely underlying pathogenic mechanism; selecting the simplest effective therapy for the underlying process, which often is only symptomatic therapy; and carefully evaluating the effect of therapy. Failure of this approach to identify the process responsible or to effect improvement signals the need for more extensive and perhaps invasive diagnostic efforts, including bronchoscopy.
Clinical manifestations suggesting that a respiratory tract illness may be life-threatening or associated with the potential for chronic disability are listed in Table 401.1 . If none of these findings is detected, the chronic respiratory process is likely to be benign. Active, well-nourished, and appropriately growing infants who present with intermittent noisy breathing but no other physical or laboratory abnormalities require only symptomatic treatment and parental reassurance. Benign-appearing but persistent symptoms are occasionally the harbinger of a serious lower respiratory tract problem. By contrast, occasionally children (e.g., with infection-related asthma) have recurrent life-threatening episodes but few or no symptoms in the intervals. Repeated examinations over an extended period, both when the child appears healthy and when the child is symptomatic, may be helpful in sorting out the severity and chronicity of lung disease.
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Cough is a reflex response of the lower respiratory tract to stimulation of irritant or cough receptors in the airways’ mucosa. The most common cause of recurrent or persistent cough in children is airway reactivity (asthma). Because cough receptors also reside in the pharynx, paranasal sinuses, stomach, and external auditory canal, the source of a persistent cough may need to be sought beyond the lungs. Specific lower respiratory stimuli include excessive secretions, aspirated foreign material, inhaled dust particles or noxious gases, cold or dry air, and an inflammatory response to infectious agents or allergic processes. Table 401.2 lists some of the conditions responsible for chronic cough. Table 401.3 presents characteristics of cough that can aid in distinguishing a cough's origin. Additional useful information can include a history of atopic conditions (asthma, eczema, urticaria, allergic rhinitis), a seasonal or environmental variation in frequency or intensity of cough, and a strong family history of atopic conditions, all suggesting an allergic cause; symptoms of malabsorption or family history indicating cystic fibrosis; symptoms related to feeding, suggesting aspiration or gastroesophageal reflux; a choking episode, suggesting foreign-body aspiration; headache or facial edema associated with sinusitis; and a smoking history in older children and adolescents or the presence of a smoker in the home ( Table 401.4 ).
RECURRENT COUGH |
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PERSISTENT COUGH |
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SYMPTOMS AND SIGNS | POSSIBLE UNDERLYING ETIOLOGY * |
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Auscultatory findings (wheeze, crepitations/crackles, differential breath sounds) | Asthma, bronchitis, pneumonia, congenital lung disease, foreign body aspiration, airway abnormality |
Cough characteristics (e.g., cough with choking, cough quality, cough starting from birth) | Congenital airway or lung abnormalities |
Cardiac abnormalities (including murmurs) | Any cardiac illness |
Chest pain | Asthma, functional, pleuritis |
Chest wall deformity | Any chronic lung disease, neuromuscular disorders |
Daily moist or productive cough | Chronic bronchitis, suppurative lung disease |
Digital clubbing | Suppurative lung disease, arteriovenous shunt |
Dyspnea (exertional or at rest) | Compromised lung function of any chronic lung or cardiac disease |
Failure to thrive | Compromised lung function, immunodeficiency, cystic fibrosis |
Feeding difficulties (including choking and vomiting) | Compromised lung function, aspiration, anatomic disorders |
Hemoptysis | Bronchitis, foreign body aspiration, suctioning trauma, pulmonary hemorrhage |
Immune deficiency | Atypical and typical recurrent respiratory or nonrespiratory infections |
Medications or drugs | Angiotensin-converting enzyme inhibitors, puffers, illicit drug use |
Neurodevelopmental abnormality | Aspiration |
Recurrent pneumonia | Immunodeficiency, congenital lung problem, airway abnormality |
Symptoms of upper respiratory tract infection | Can coexist or be a trigger for an underlying problem |
* This is not an exhaustive list; only the more common respiratory diseases are mentioned.
CHARACTERISTIC | THINK OF |
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Staccato, paroxysmal | Pertussis, cystic fibrosis, foreign body, Chlamydia spp., Mycoplasma spp. |
Followed by “whoop” | Pertussis |
All day, never during sleep | Habit cough |
Barking, brassy | Croup, habit cough, tracheomalacia, tracheitis, epiglottitis |
Hoarseness | Laryngeal involvement (croup, recurrent laryngeal nerve involvement), papillomatosis |
Abrupt onset | Foreign body, pulmonary embolism |
During or following exercise | Reactive airway disease |
Accompanies eating, drinking | Aspiration, gastroesophageal reflux, tracheoesophageal fistula |
Throat clearing | Postnasal drip, vocal tic |
Productive (sputum) | Infection, cystic fibrosis, bronchiectasis |
Night cough | Sinusitis, reactive airway disease, gastroesophageal reflux |
Seasonal | Allergic rhinitis, reactive airway disease |
Immunosuppressed patient | Bacterial pneumonia, Pneumocystis jiroveci , Mycobacterium tuberculosis , Mycobacterium avium-intracellulare , cytomegalovirus, fungi |
Dyspnea | Hypoxia, hypercarbia |
Animal exposure | Chlamydia psittaci (birds), Yersinia pestis (rodents), Francisella tularensis (rabbits), Q fever (sheep, cattle), hantavirus (rodents), histoplasmosis (pigeons) |
Geographic | Histoplasmosis (Mississippi, Missouri, Ohio River Valley), coccidioidomycosis (Southwest), blastomycosis (North and Midwest) |
Workdays with clearing on days off | Occupational exposure |
The physical examination can provide much information pertaining to the cause of chronic cough. Posterior pharyngeal drainage combined with a nighttime cough suggests chronic upper airway disease such as sinusitis. An overinflated chest suggests chronic airway obstruction, as in asthma or cystic fibrosis. An expiratory wheeze, with or without diminished intensity of breath sounds, strongly suggests asthma or asthmatic bronchitis, but may also be consistent with a diagnosis of cystic fibrosis, bronchomalacia, vascular ring, aspiration of foreign material, or pulmonary hemosiderosis. Careful auscultation during forced expiration may reveal expiratory wheezes that are otherwise undetectable and that are the only indication of underlying reactive airways. Coarse crackles suggest bronchiectasis, including cystic fibrosis, but can also occur with an acute or subacute exacerbation of asthma. Clubbing of the digits is seen in most patients with bronchiectasis but in only a few other respiratory conditions with chronic cough (see Table 401.2 ). Tracheal deviation suggests foreign body aspiration, pleural effusion, or a mediastinal mass.
Allowing sufficient examination time to detect a spontaneous cough is important. If a spontaneous cough does not occur, asking the child to take a maximal breath and forcefully exhale repeatedly usually induces a cough reflex. Most children can cough on request by 4-5 yr of age. Children who cough as often as several times a minute with regularity are likely to have a habit (tic) cough (see Chapter 37 ). If the cough is loose, every effort should be made to obtain sputum; many older children can comply. It is sometimes possible to pick up small bits of sputum with a throat swab quickly inserted into the lower pharynx while the child coughs with the tongue protruding. Clear mucoid sputum is most often associated with an allergic reaction or asthmatic bronchitis. Cloudy (purulent) sputum suggests a respiratory tract infection but can also reflect increased cellularity (eosinophilia) from an asthmatic process. Very purulent sputum is characteristic of bronchiectasis (see Chapter 430 ). Malodorous expectorations suggest anaerobic infection of the lungs. In cystic fibrosis (see Chapter 432 ), the sputum, even when purulent, is rarely foul smelling.
Laboratory tests can help in the evaluation of a chronic cough. Only sputum specimens containing alveolar macrophages should be interpreted as reflecting lower respiratory tract processes. Sputum eosinophilia suggests asthma, asthmatic bronchitis, or hypersensitivity reactions of the lung (see Chapter 418 ), but a polymorphonuclear cell response suggests infection; if sputum is unavailable, the presence of eosinophilia in nasal secretions also suggests atopic disease. If most of the cells in sputum are macrophages, postinfectious hypersensitivity of cough receptors should be suspected. Sputum macrophages can be stained for hemosiderin content, which is diagnostic of pulmonary hemosiderosis (see Chapter 435 ), or for lipid content, which in large amounts suggests, but is not specific for, repeated aspiration. Rarely, children may expectorate partial casts of the airway, which can be characterized in investigating causes of plastic bronchitis. Children whose coughs persist for more than 6 wk should be tested for cystic fibrosis regardless of their race or ethnicity (see Chapter 432 ). Sputum culture is helpful in evaluation of cystic fibrosis, but less so for other conditions because throat flora can contaminate the sample.
Hematologic assessment can reveal a microcytic anemia that is the result of pulmonary hemosiderosis (see Chapter 435 ) or hemoptysis, or eosinophilia that accompanies asthma and other hypersensitivity reactions of the lung. Infiltrates on the chest radiograph suggest cystic fibrosis, bronchiectasis, foreign body, hypersensitivity pneumonitis, tuberculosis, or other infection. When asthma-equivalent cough is suggested, a trial of bronchodilator therapy may be diagnostic. If the cough does not respond to initial therapeutic efforts, more-specific diagnostic procedures may be warranted, including an immunologic or allergic evaluation, chest and paranasal sinus imaging, esophagograms, tests for gastroesophageal reflux (see Chapter 349 ), and special microbiologic studies including rapid viral testing. Evaluation of ciliary morphology, nasal endoscopy, laryngoscopy, and bronchoscopy may also be indicated.
Tic cough or somatic cough disorder (psychogenic cough or habit cough) must be considered in any child with a cough that has lasted for weeks or months, that has been refractory to treatment, and that disappears with sleep or with distraction. Typically, the cough is abrupt and loud, and has a harsh, honking, or barking quality. A disassociation between the intensity of the cough and the child's affect is typically striking. This cough may be absent if the physician listens outside the examination room, but it will reliably appear immediately on direct attention to the child and the symptom. It typically begins with an upper respiratory infection but then lingers. The child misses many days of school because the cough disrupts the classroom. This disorder accounts for many unnecessary medical procedures and courses of medication. It is treatable with assurance that a pathologic lung condition is absent and that the child should resume full activity, including school. This assurance, together with speech therapy techniques that allow the child to reduce musculoskeletal tension in the neck and chest and that increase the child's awareness of the initial sensations that trigger cough, has been very successful. Self-hypnosis is another successful therapy, often effective with 1 session. The designation “tic cough” or “somatic cough disorder” is preferable to “habit cough” or “psychogenic cough” because it carries no stigma and because most of these children do not have significant emotional problems. When the cough disappears, it does not reemerge as another symptom. Nonetheless, other symptoms such as irritable bowel syndrome may be present in the patient or family.
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