Chronic or Recurrent Respiratory Symptoms


Respiratory tract symptoms, including cough, wheeze, and stridor, occur frequently or persist for long periods in a substantial number of children; other children have persistent or recurring lung infiltrates with or without symptoms. Determining the cause of these chronic findings can be difficult because symptoms can be caused by a close succession of unrelated acute respiratory tract infections or by a single pathophysiologic process. Specific and easily performed diagnostic tests do not exist for many acute and chronic respiratory conditions. Pressure from the affected child's family for a quick remedy because of concern over symptoms related to breathing may complicate diagnostic and therapeutic efforts.

A systematic approach to the diagnosis and treatment of these children consists of assessing whether the symptoms are the manifestation of a minor problem or a life-threatening process; determining the most likely underlying pathogenic mechanism; selecting the simplest effective therapy for the underlying process, which often is only symptomatic therapy; and carefully evaluating the effect of therapy. Failure of this approach to identify the process responsible or to effect improvement signals the need for more extensive and perhaps invasive diagnostic efforts, including bronchoscopy.

Judging the Seriousness of Chronic Respiratory Complaints

Clinical manifestations suggesting that a respiratory tract illness may be life-threatening or associated with the potential for chronic disability are listed in Table 401.1 . If none of these findings is detected, the chronic respiratory process is likely to be benign. Active, well-nourished, and appropriately growing infants who present with intermittent noisy breathing but no other physical or laboratory abnormalities require only symptomatic treatment and parental reassurance. Benign-appearing but persistent symptoms are occasionally the harbinger of a serious lower respiratory tract problem. By contrast, occasionally children (e.g., with infection-related asthma) have recurrent life-threatening episodes but few or no symptoms in the intervals. Repeated examinations over an extended period, both when the child appears healthy and when the child is symptomatic, may be helpful in sorting out the severity and chronicity of lung disease.

Table 401.1
Indicators of Serious Chronic Lower Respiratory Tract Disease in Children
  • Persistent fever

  • Ongoing limitation of activity

  • Failure to grow

  • Failure to gain weight appropriately

  • Clubbing of the digits

  • Persistent tachypnea and labored ventilation

  • Shortness of breath and exercise intolerance

  • Chronic purulent sputum

  • Persistent hyperinflation

  • Substantial and sustained hypoxemia

  • Refractory infiltrates on chest x-ray

  • Persistent pulmonary function abnormalities

  • Hemoptysis

  • Family history of heritable lung disease

  • Cyanosis and hypercarbia

  • Unusual (opportunistic) or recurrent nonpulmonary infections

Recurrent or Persistent Cough

Cough is a reflex response of the lower respiratory tract to stimulation of irritant or cough receptors in the airways’ mucosa. The most common cause of recurrent or persistent cough in children is airway reactivity (asthma). Because cough receptors also reside in the pharynx, paranasal sinuses, stomach, and external auditory canal, the source of a persistent cough may need to be sought beyond the lungs. Specific lower respiratory stimuli include excessive secretions, aspirated foreign material, inhaled dust particles or noxious gases, cold or dry air, and an inflammatory response to infectious agents or allergic processes. Table 401.2 lists some of the conditions responsible for chronic cough. Table 401.3 presents characteristics of cough that can aid in distinguishing a cough's origin. Additional useful information can include a history of atopic conditions (asthma, eczema, urticaria, allergic rhinitis), a seasonal or environmental variation in frequency or intensity of cough, and a strong family history of atopic conditions, all suggesting an allergic cause; symptoms of malabsorption or family history indicating cystic fibrosis; symptoms related to feeding, suggesting aspiration or gastroesophageal reflux; a choking episode, suggesting foreign-body aspiration; headache or facial edema associated with sinusitis; and a smoking history in older children and adolescents or the presence of a smoker in the home ( Table 401.4 ).

Table 401.2
Differential Diagnosis of Recurrent and Persistent Cough in Children
RECURRENT COUGH
  • Reactive airway disease (asthma)

  • Drainage from upper airways

  • Aspiration

  • Frequently recurring respiratory tract infections in immunocompetent or immunodeficient patients

  • Symptomatic Chiari malformation

  • Idiopathic pulmonary hemosiderosis

  • Hypersensitivity (allergic) pneumonitis

PERSISTENT COUGH
  • Hypersensitivity of cough receptors after infection

  • Reactive airway disease (asthma)

  • Chronic sinusitis

  • Chronic rhinitis (allergic or nonallergic)

  • Bronchitis or tracheitis caused by infection or smoke exposure

  • Bronchiectasis, including cystic fibrosis, primary ciliary dyskinesia, immunodeficiency

  • Habit cough

  • Foreign-body aspiration

  • Recurrent aspiration owing to pharyngeal incompetence, tracheolaryngoesophageal cleft, or tracheoesophageal fistula

  • Gastroesophageal reflux, with or without aspiration

  • Pertussis

  • Extrinsic compression of the tracheobronchial tract (vascular ring, neoplasm, lymph node, lung cyst)

  • Tracheomalacia, bronchomalacia

  • Endobronchial or endotracheal tumors

  • Endobronchial tuberculosis

  • Hypersensitivity pneumonitis

  • Fungal infections

  • Inhaled irritants, including tobacco smoke

  • Irritation of external auditory canal

  • Angiotensin-converting enzyme inhibitors

Table 401.3
Characteristics of Cough and Other Clinical Features and Possible Causes
Modified from Chang AB, Landau LI, Van Asperen PP, et al: Cough in children: definitions and clinical evaluation. Thoracic Society of Australia and New Zealand, Med J Aust 184(8):398–403, 2006, Table 2, p. 399.
SYMPTOMS AND SIGNS POSSIBLE UNDERLYING ETIOLOGY *
Auscultatory findings (wheeze, crepitations/crackles, differential breath sounds) Asthma, bronchitis, pneumonia, congenital lung disease, foreign body aspiration, airway abnormality
Cough characteristics (e.g., cough with choking, cough quality, cough starting from birth) Congenital airway or lung abnormalities
Cardiac abnormalities (including murmurs) Any cardiac illness
Chest pain Asthma, functional, pleuritis
Chest wall deformity Any chronic lung disease, neuromuscular disorders
Daily moist or productive cough Chronic bronchitis, suppurative lung disease
Digital clubbing Suppurative lung disease, arteriovenous shunt
Dyspnea (exertional or at rest) Compromised lung function of any chronic lung or cardiac disease
Failure to thrive Compromised lung function, immunodeficiency, cystic fibrosis
Feeding difficulties (including choking and vomiting) Compromised lung function, aspiration, anatomic disorders
Hemoptysis Bronchitis, foreign body aspiration, suctioning trauma, pulmonary hemorrhage
Immune deficiency Atypical and typical recurrent respiratory or nonrespiratory infections
Medications or drugs Angiotensin-converting enzyme inhibitors, puffers, illicit drug use
Neurodevelopmental abnormality Aspiration
Recurrent pneumonia Immunodeficiency, congenital lung problem, airway abnormality
Symptoms of upper respiratory tract infection Can coexist or be a trigger for an underlying problem

* This is not an exhaustive list; only the more common respiratory diseases are mentioned.

Table 401.4
Clinical Clues About Cough
From Kliegman RM, Greenbaum LA, Lyle PS: Practical strategies in pediatric diagnosis and therapy, ed 2, Philadelphia, 2004, WB Saunders, p. 19.
CHARACTERISTIC THINK OF
Staccato, paroxysmal Pertussis, cystic fibrosis, foreign body, Chlamydia spp., Mycoplasma spp.
Followed by “whoop” Pertussis
All day, never during sleep Habit cough
Barking, brassy Croup, habit cough, tracheomalacia, tracheitis, epiglottitis
Hoarseness Laryngeal involvement (croup, recurrent laryngeal nerve involvement), papillomatosis
Abrupt onset Foreign body, pulmonary embolism
During or following exercise Reactive airway disease
Accompanies eating, drinking Aspiration, gastroesophageal reflux, tracheoesophageal fistula
Throat clearing Postnasal drip, vocal tic
Productive (sputum) Infection, cystic fibrosis, bronchiectasis
Night cough Sinusitis, reactive airway disease, gastroesophageal reflux
Seasonal Allergic rhinitis, reactive airway disease
Immunosuppressed patient Bacterial pneumonia, Pneumocystis jiroveci , Mycobacterium tuberculosis , Mycobacterium avium-intracellulare , cytomegalovirus, fungi
Dyspnea Hypoxia, hypercarbia
Animal exposure Chlamydia psittaci (birds), Yersinia pestis (rodents), Francisella tularensis (rabbits), Q fever (sheep, cattle), hantavirus (rodents), histoplasmosis (pigeons)
Geographic Histoplasmosis (Mississippi, Missouri, Ohio River Valley), coccidioidomycosis (Southwest), blastomycosis (North and Midwest)
Workdays with clearing on days off Occupational exposure

The physical examination can provide much information pertaining to the cause of chronic cough. Posterior pharyngeal drainage combined with a nighttime cough suggests chronic upper airway disease such as sinusitis. An overinflated chest suggests chronic airway obstruction, as in asthma or cystic fibrosis. An expiratory wheeze, with or without diminished intensity of breath sounds, strongly suggests asthma or asthmatic bronchitis, but may also be consistent with a diagnosis of cystic fibrosis, bronchomalacia, vascular ring, aspiration of foreign material, or pulmonary hemosiderosis. Careful auscultation during forced expiration may reveal expiratory wheezes that are otherwise undetectable and that are the only indication of underlying reactive airways. Coarse crackles suggest bronchiectasis, including cystic fibrosis, but can also occur with an acute or subacute exacerbation of asthma. Clubbing of the digits is seen in most patients with bronchiectasis but in only a few other respiratory conditions with chronic cough (see Table 401.2 ). Tracheal deviation suggests foreign body aspiration, pleural effusion, or a mediastinal mass.

Allowing sufficient examination time to detect a spontaneous cough is important. If a spontaneous cough does not occur, asking the child to take a maximal breath and forcefully exhale repeatedly usually induces a cough reflex. Most children can cough on request by 4-5 yr of age. Children who cough as often as several times a minute with regularity are likely to have a habit (tic) cough (see Chapter 37 ). If the cough is loose, every effort should be made to obtain sputum; many older children can comply. It is sometimes possible to pick up small bits of sputum with a throat swab quickly inserted into the lower pharynx while the child coughs with the tongue protruding. Clear mucoid sputum is most often associated with an allergic reaction or asthmatic bronchitis. Cloudy (purulent) sputum suggests a respiratory tract infection but can also reflect increased cellularity (eosinophilia) from an asthmatic process. Very purulent sputum is characteristic of bronchiectasis (see Chapter 430 ). Malodorous expectorations suggest anaerobic infection of the lungs. In cystic fibrosis (see Chapter 432 ), the sputum, even when purulent, is rarely foul smelling.

Laboratory tests can help in the evaluation of a chronic cough. Only sputum specimens containing alveolar macrophages should be interpreted as reflecting lower respiratory tract processes. Sputum eosinophilia suggests asthma, asthmatic bronchitis, or hypersensitivity reactions of the lung (see Chapter 418 ), but a polymorphonuclear cell response suggests infection; if sputum is unavailable, the presence of eosinophilia in nasal secretions also suggests atopic disease. If most of the cells in sputum are macrophages, postinfectious hypersensitivity of cough receptors should be suspected. Sputum macrophages can be stained for hemosiderin content, which is diagnostic of pulmonary hemosiderosis (see Chapter 435 ), or for lipid content, which in large amounts suggests, but is not specific for, repeated aspiration. Rarely, children may expectorate partial casts of the airway, which can be characterized in investigating causes of plastic bronchitis. Children whose coughs persist for more than 6 wk should be tested for cystic fibrosis regardless of their race or ethnicity (see Chapter 432 ). Sputum culture is helpful in evaluation of cystic fibrosis, but less so for other conditions because throat flora can contaminate the sample.

Hematologic assessment can reveal a microcytic anemia that is the result of pulmonary hemosiderosis (see Chapter 435 ) or hemoptysis, or eosinophilia that accompanies asthma and other hypersensitivity reactions of the lung. Infiltrates on the chest radiograph suggest cystic fibrosis, bronchiectasis, foreign body, hypersensitivity pneumonitis, tuberculosis, or other infection. When asthma-equivalent cough is suggested, a trial of bronchodilator therapy may be diagnostic. If the cough does not respond to initial therapeutic efforts, more-specific diagnostic procedures may be warranted, including an immunologic or allergic evaluation, chest and paranasal sinus imaging, esophagograms, tests for gastroesophageal reflux (see Chapter 349 ), and special microbiologic studies including rapid viral testing. Evaluation of ciliary morphology, nasal endoscopy, laryngoscopy, and bronchoscopy may also be indicated.

Tic cough or somatic cough disorder (psychogenic cough or habit cough) must be considered in any child with a cough that has lasted for weeks or months, that has been refractory to treatment, and that disappears with sleep or with distraction. Typically, the cough is abrupt and loud, and has a harsh, honking, or barking quality. A disassociation between the intensity of the cough and the child's affect is typically striking. This cough may be absent if the physician listens outside the examination room, but it will reliably appear immediately on direct attention to the child and the symptom. It typically begins with an upper respiratory infection but then lingers. The child misses many days of school because the cough disrupts the classroom. This disorder accounts for many unnecessary medical procedures and courses of medication. It is treatable with assurance that a pathologic lung condition is absent and that the child should resume full activity, including school. This assurance, together with speech therapy techniques that allow the child to reduce musculoskeletal tension in the neck and chest and that increase the child's awareness of the initial sensations that trigger cough, has been very successful. Self-hypnosis is another successful therapy, often effective with 1 session. The designation “tic cough” or “somatic cough disorder” is preferable to “habit cough” or “psychogenic cough” because it carries no stigma and because most of these children do not have significant emotional problems. When the cough disappears, it does not reemerge as another symptom. Nonetheless, other symptoms such as irritable bowel syndrome may be present in the patient or family.

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