Conflicts of Interest The authors have no conflicts of interest to declare. The views expressed are the authors' own and do not represent the National Institutes of Health, the Department of Health and Human Services, or the US Federal government.…
Introduction Chimeric antigen receptor (CAR) T-cell immunotherapy is a rapidly emerging and highly publicized new treatment modality, which has gained significant attention for its effectiveness, side effects, and costs. Early-phase clinical trials have shown dramatic results in patients with often…
Plain Language Summary Breast cancer screening has been going on for many years now, and research suggests that most women in the community feel positive about screening as a way to reassure them that they are well or to find…
Plain Language Summary Women with screen-detected breast cancers have better survival than those with symptomatic breast cancers. Many screen-detected cancers are low risk because they are unlikely to recur or to cause death, with between 11% and 19% of screen-detected…
Plain Language Summary Breast screening is a large public health program with a significant reach. It is shaped by existing patterns of acting and reasoning, and challenges us to think differently about society and ethics. Social attitudes about the breast…
Plain Language Summary Mammography screening has been adopted in many countries and population health programs because randomized trials showed that it reduces the risk of dying from breast cancer. These randomized trials used screen-film mammography (SFM) which means that the…
Plain Language Summary Following successful treatment of first breast cancers, women remain at risk of cancer recurrence in the treated breast and also new cancers in the other breast (second breast cancers), which are associated with increased rates of cancer…
Plain Language Summary Women with certain genetic mutations (eg, BRCA1 and BRCA2 ) or with familial risk (without a known gene mutation but with a strong family history of breast or ovarian cancer) are at an elevated risk of developing…
Plain Language Summary Mammography is the only screening test that reduces death from breast cancer in randomized trials. However, it does not detect all cancers that are present. One of the reasons that mammography misses cancers is that dense areas…
Plain Language Summary Women in their 40s face conflicting breast cancer screening guidelines that are based on different interpretations of research and considerations of the benefits and harms of screening. How well mammography screening reduces death from breast cancer was…