Category Hematology, Oncology, and Palliative Medicine

Hematology, Oncology, and Palliative Medicine

Nanotechnological approaches in cancer : the role of celecoxib and disulfiram

Acknowledgments The authors acknowledge Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Agency for Scientific Research, for financial support through the Research Project no. 016648 (Ref. POCI-01-0145-FEDER-016648), the project PEst-UID/NEU/04539/2013, and COMPETE (Ref. POCI-01-0145-FEDER-007440). The Coimbra Chemistry Centre is supported…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Nanoparticle-based formulation for drug repurposing in cancer treatment

Introduction of nanomedicine Nanomedicine was first entered the preclinical in the mid-1980s, and the first product is PEGylated adenosine deaminase enzyme that was approved by FDA in early 1990 [ ]. Ever since then, scientists hold great passion in this…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Drugs repurposed to potentiate immunotherapy for cancer treatment

Introduction Cancer is a leading cause of death worldwide. Given the unmet need for more effective anticancer therapy, intense efforts have been invested in searching for better anticancer drugs in a more efficient manner. Pharmaceutical companies and academic investigators alike…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Identification of chemosensitizers by drug repurposing to enhance the efficacy of cancer therapy

Acknowledgments A Ph.D. stipend of the Chinese Scholarship Council to G.Y. is gratefully acknowledged. Introduction The development of drug resistance, which eventually leads to therapy failure and tumor relapse, emerges as a major challenge in cancer treatment. Clinic drug resistance…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Animal models and in vivo investigations for drug repurposing in lung cancer

Introduction Lung cancer is one of the most common and serious types of cancer, which causes the highest cancer mortality among men and women worldwide. The two major types of lung cancers are small cell lung cancer (SCLC) and non-small…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Stories of drug repurposing for pancreatic cancer treatment—Past, present, and future

Acknowledgments We want to apologize to all authors whose work could not be cited due to space restrictions/limitations in this chapter. Introduction Cancer in general is one of the leading causes of mortality worldwide [ ]. Pancreatic ductal adenocarcinoma (PDAC),…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma

Hepatocellular carcinoma Hepatocellular carcinoma (HCC) is a major health problem with devastating consequences associated with treatment failure. It has an estimated global incidence of more than 850,000 new cases annually [ ]. HCC is currently the second leading cause of…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

A personalized medicine approach to drug repurposing for the treatment of breast cancer molecular subtypes

Introduction Breast cancer is a major public health concern and a relevant mortality issue in young women worldwide [ ]. Mammary tumors are extremely heterogeneous at the histological, molecular, and systemic levels. To handle such variability, oncology researchers and clinicians…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

The success story of drug repurposing in breast cancer

Introduction Breast cancer is the most prevalent cancer in women worldwide, and despite tremendous research efforts, it remains the second leading cause of cancer-related mortalities among women ( ). According to the 2018 GLOBOCAN report, over 2 million new…

Drug Repurposing in Cancer Therapy
December 24, 2023

Hematology, Oncology, and Palliative Medicine

Increasing opportunities of drug repurposing for treating breast cancer by the integration of molecular, histological, and systemic approaches

List of abbreviations 2-DG 2-Deoxyglucose 2-FDG 2-Fludeoxyglucose 3D Three direct-acting antivirals ABC7 Adjuvant for breast cancer treatment using seven repurposed drugs ABCG2 ATP-binding cassette superfamily G member 2 ADH Alcohol dehydrogenase ADRB Adrenoreceptor beta ALDH Aldehyde dehydrogenase AMP Adenosine monophosphate…

Drug Repurposing in Cancer Therapy
December 24, 2023