This chapter will focus on the acquired etiologies of neonatal thrombocytopenia as congenital and alloimmune thrombocytopenias are discussed in Chapter 93, Chapter 94 . Neonatal thrombocytopenia occurs in 1%–2% of healthy term neonates but is common in the neonatal intensive…
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is characterized by the presence of transient isolated neonatal thrombocytopenia secondary to maternal antibodies against paternally inherited antigens expressed on the fetal platelets. FNAIT is the most common cause of severe thrombocytopenia (<50,000/μL) in…
Introduction Inherited thrombocytopenia was once considered a rare disease, but more recent studies using next-generation sequencing (NGS) and genome-wide association studies suggest that the prevalence of inherited or familial thrombocytopenia may be much higher than originally appreciated and that some…
Basic Considerations for Evaluation of a Pediatric Patient With a Bleeding Disorder Children with bleeding disorders generally present with mild bleeding symptoms including easy bruising, epistaxis, gum bleeding, abnormal clotting tests from presurgical evaluation, or known family history of bleeding…
Hemostasis means stopping blood loss or bleeding. Hemostasis is an orchestrated, balanced, and tightly regulated process. Hemostasis can be subdivided into three sequential processes: primary hemostasis, secondary hemostasis and tertiary hemostasis. In primary hemostasis the interaction of the injured endothelium…
In many hospitals, management of human tissue, specifically tissue allografts, has been centralized. Centralized tissue services coordinate the supply, dispensing, and accounting of products among numerous clinical services and have an infrastructure to efficiently receive, process, store, issue, and manage…
Cellular therapy is the use of viable cells and tissues for the treatment of disease. Modern cell-based therapies include regenerative medicine, which is the process of replacing or regenerating human cells, tissues, or organs to restore or establish normal function.…
Adverse events associated with hematopoietic progenitor cell (HPC) product infusion can vary depending on the type of product infused ( Table 88.1 ). The Center for Disease Control National Health Safety Network provides a Biovigilance Component Hemovigilance Module Surveillance Protocol…
Cellular therapies designed to modulate or enhance immune responses are gaining acceptance as viable treatments for a variety of diseases, most notably in the oncology field. Some therapies such as granulocyte infusion have been a tool in transfusion medicine for…
Regenerative medicine is a multidisciplinary field focused on repair, replacement and/or regeneration of diseased cells or organs, or in many cases on protecting vulnerable diseased cells from death. Stem cell (SC) therapies are at the core of many regenerative therapies,…