Introduction Cancer is the second leading cause of death globally, accounting for approximately 9.6 million deaths in 2018. The impact of cancer morbidity is significant and continues to rise, with an annual cost of approximately US$1.16 trillion in 2010. There…
General Introduction: Anesthesia and Cancer Progression Surgery remains a central treatment modality for patients with solid cancers, with more than 60% of cancer patients presenting for surgical resection, and more than 80% of cancer patients exposed to a surgical procedure…
The Perioperative Period Is Critical for Postsurgical Cancer Outcomes Surgery is the primary and often the most effective treatment for many solid tumors. However, even otherwise successful surgeries may disrupt and disseminate tumor cells. Disseminated tumor cells increase the risk…
The Perioperative Period—An Underutilized “Window-of-Opportunity” to Prevent Metastatic Disease The occurrence of metastatic disease is the leading cause of death in most patients with cancer. Accumulating evidence suggests that the perioperative period, days to weeks before and after surgery, is…
Introduction As surgical and anesthetic techniques have evolved, perioperative mortality in complex cancer surgical interventions has decreased significantly. However, complications and associated morbidity remain a challenge not only for surgical recovery, but also for functional restoration, completion of care for…
Introduction The management of cancer patients has evolved exponentially over time. At the start of the 19th century surgery was the only available modality to treat cancer, and surgery itself was limited to superficial tumors such as breast and skin…
Introduction At the intersection of oncology and cardiology, the field of cardio-oncology is growing primarily with the aim of recognizing, monitoring, and treating cardiovascular complications resulting from cancer-related treatments. With advances in cardiac imaging technologies, we now have a much…
Introduction There have been rapid and substantial advances in cancer treatment with improved systemic therapies, including chemotherapy, hormone therapy, targeted therapy, and immunotherapy, as well as recent technologic advances in radiation therapy. This has led to new combinations and sequences…
Introduction Preoperative cancer therapies such as chemotherapy and radiation can have direct implications on perioperative management during cancer surgery. Chemotherapy is intended to prevent proliferation of malignant cells (cytostatic) and cause death of tumor cells (cytotoxic). It can be given…
Introduction In spite of the evident cytoreductive, potentially curative advantages of surgery, there has long been a suspicion that resecting primary tumors carries an intrinsic, paradoxical risk with respect to disease progression. , Anecdotal evidence prompted surgeons in the second…