Donors of cells or organs are important potential sources of infection in children undergoing hematopoietic stem cell (HSCT) or solid organ transplantation (SOT). In both settings, the donor may be a source of anticipated or unanticipated transmission of pathogens to…
Basic principles of the infectious disease pretransplant evaluation The pretransplant infectious disease evaluation represents the first step in a long continuum of infection prevention that extends into the posttransplant period. This evaluation is a critical element in the pretransplant process…
Invasive infections are a common source of morbidity and mortality in children with cancer. The risk for infectious complications during therapy for cancer is inversely related to age: children with cancer are more commonly affected by infection compared with adult…
Infections are one of the most frequent serious complications of hematopoietic stem cell transplantation (HSCT). The risk of infections corresponds to the complex interplay between organ dysfunction or tissue damage, exposure to pathogens, virulence of those pathogens, and the net…
Balanced immunosuppression is essential to ensure acceptance of a solid organ transplant and an overall successful patient outcome. The fundamental purpose of immunosuppression is to modulate the immune system’s ability to recognize the transplanted organ. However, an overly suppressed immune…