Netter's Obstetrics and Gynecology

Granulosa Cell Tumors

Introduction Description: A granulosa cell tumor is a sex cord stromal tumor of the ovary made up of granulosa cells (sex cord) and stromal cells (thecal cells or fibroblasts). The tumor often secretes estrogen. Prevalence: 2%–5% of ovarian neoplasms and…

Germ Cell Tumor

Introduction Description: Germ cell tumors contain cells that echo the three layers of embryonic tissue (ectoderm, mesoderm, and endoderm) or extraembryonic elements. Prevalence: Second most frequent ovarian neoplasm (25% of tumors) and the most common ovarian tumor in women younger…

Epithelial Stromal Ovarian Tumors

Introduction Description: The most common type of ovarian tumors (65% of ovarian tumors, 95% of ovarian malignancies). Epithelial stromal tumors are derived from the surface (celomic) epithelium and the ovarian stroma and include serous (20%–50%), mucinous (15%–25%), endometrioid (5%), clear…

Endometriosis

Introduction Description: Endometriosis is a benign but progressive condition characterized by endometrial glands and stroma that are found in locations other than the endometrium (may be found outside of the pelvis in the abdomen, thorax, brain, and skin). Prevalence: 5%–15%…

Ectopic Pregnancy

Introduction Description: An ectopic pregnancy is one in which the fertilized egg is implanted outside of the endometrial cavity (fallopian tube [98%], ovary, abdominal cavity, or cervix). This is the leading cause of pregnancy-related maternal death in the first trimester…

Dysgerminoma

Introduction Description: A dysgerminoma is an ovarian tumor that is made up of germ cells and stroma that appears analogous in structure to the seminomas found in the male testes. Although rare, these tumors are the most common malignant germ…

Dermoid Cyst (Teratoma)

Introduction Description: The most common ovarian tumor in young, reproductive-aged women is the cystic teratoma or dermoid, which originates from a germ cell and contains elements from all three germ cell layers. These tumors may be benign or malignant (1%–2%…

Clear Cell Carcinoma

Introduction Description: A clear cell carcinoma is an ovarian epithelial tumor comprising cells containing large amounts of glycogen, giving them a clear or “hobnailed” appearance. These tumors may also arise in the endocervix, endometrium, and vagina. Cervical and vaginal tumors…

Adenofibroma

Introduction Description: An adenofibroma is an epithelial tumor that consists of glandular elements and large amounts of stromal (fibrous) elements. Adenofibromas are most commonly found as ovarian masses. They may also occur in the cervix or uterine body. Adenofibromas are…