Overview of Incidence and Clinicopathologic Associations Theoretically, the spectrum of liver disease in renal transplant recipients should mimic the spectrum of disease seen in society. It is axiomatic that renal transplant recipients are at risk for all the acute and…
Overview Successful management of infections in kidney transplant recipients is a function of the immune status of the host and the epidemiology of infectious exposures. Transplant recipients are susceptible to a broad spectrum of infectious pathogens while manifesting diminished signs…
Introduction A successful renal transplant is the most effective way of reducing the incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD). Although the risk of CVD in renal transplant recipients (RTR) is…
Urologic complications are inevitable in renal transplantation. Their incidence and effect on graft survival can, however, be minimized. This chapter reviews the types of urologic complications that may occur, maneuvers to prevent them, when to suspect and how to diagnose…
Introduction The enduring techniques of vascular anastomoses described by Alexis Carrel more than a century ago have not changed significantly (see Chapter 1 ). His simple test of satisfactory vascular anastomosis was observation of a viable kidney transplant producing urine…
Acknowledgments I am grateful for the excellent photomicrographs provided by Dr. Rajathurai Murugasa and Professor Ranjit S. Nanra of John Hunter Hospital, Newcastle, NSW, Australia. Introduction Epidemiology Despite the success of modern kidney transplantation where early acute rejection rates are…
Acknowledgments Original work by the authors was funded by the NIH (grant 1U01AI070107) and National Health and Medical Research Council of Australia. Karen Keung is a recipient of the Jacquot Research Entry Scholarship from the Royal Australasian College of Physicians…
Abbreviations AMR antibody-mediated rejection ATN acute tubular necrosis CAN chronic allograft nephropathy CMV cytomegalovirus CNI calcineurin inhibitor CNIT calcineurin inhibitor toxicity DGF delayed graft function DSA donor-specific antibody EM electron microscopy FSGS focal segmental glomerulosclerosis GBM glomerular basement membrane HLA…
It is a favorite assertion of the authors that clinical transplantation is an excellent example of “medical ethics in practice.” Perhaps this is best demonstrated by the processes of organ allocation where a balance must be struck between allocation that…
Introduction There are far more eligible kidney transplant candidates worldwide than there are organs available. Kidney exchange, also referred to as paired kidney donation, has become strongly established over the past decade as a modality for facilitating living kidney donation…