Acknowledgement The authors are grateful to Mr Stephen O’Neill, consultant transplant surgeon, Belfast City Hospital, for his comprehensive contribution to a previous edition of this chapter. Introduction Surgical management of portal hypertension with portosystemic vascular shunts has essentially been rendered…
Introduction Colorectal cancer (CRC) is the second most common cancer diagnosed in women and the third most common cancer diagnosed in men worldwide. The majority of CRC-related mortality is due to metastatic disease with the liver being the most common…
Introduction Despite recent advances in screening, diagnosis and management, colorectal cancer (CRC) remains the second leading cause of cancer death in Western countries. In 2018, 1.8 million new CRC cases were estimated to have occurred worldwide. Almost two-thirds of patients…
Introduction Primary liver malignancies comprise a group of tumours, some very rare, that have traditionally been divided into three main categories based on the cell type of origin—hepatocellular (hepatocellular carcinoma [HCC]), biliary (intrahepatic cholangiocarcinoma [ICC]), and mesenchymal (angiosarcoma, epithelioid haemangioendothelioma).…
Introduction Benign liver tumours are common and frequently found coincidentally. Most benign liver lesions are asymptomatic, although larger lesions can cause non-specific complaints such as vague abdominal pain. Although rare, some of the benign lesions, e.g. large hepatic adenomas, can…
Introduction As our understanding of the molecular mechanisms of cancer development and progression has advanced, we have seen significant improvements in therapeutic responses in patients. This arguably has been best illustrated in the field of breast cancer, where tamoxifen and…
Introduction Hepato-pancreato-biliary (HPB) surgery can present many challenges during the perioperative period. With an ageing population, there are increasing numbers of patients with significant comorbid conditions presenting for surgery. Although patient outcomes have improved with a number of advances in…
Overview of liver functions and evolution The liver is the largest solid organ in the human body. It has a unique structure with a dual blood supply, being approximately one-third from the hepatic artery and two-thirds from the portal venous…
This chapter will provide a basic anatomical foundation for performing liver, biliary and pancreatic surgery. Anatomical features that are clinically unimportant have been omitted. It is self-evident that surgeons operating in this area must have a full working knowledge of…