History and Classification The first detailed studies of what is now recognized as T-cell large granular lymphocytic leukemia (T-LGL) were published in the 1970s and early 1980s. These manuscripts described a disorder associated with neutropenia or anemia that was associated…
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus with tropism for B cells. More than 90% of humans are infected with EBV, and the infection persists for life. Usually primary infection is asymptomatic and occurs early in life, and when symptomatic…
The spectrum of virally associated B-cell lymphoproliferative diseases is broad, ranging from reactive lymphadenitis to lymphomas. Often the reactive processes can be diagnostically challenging and mimic lymphomas due to a combination of direct viral effects and indirect ones mediated by…
Definition Classical Hodgkin's lymphoma (CHL) is a clonal, malignant lymphoproliferation originating from germinal-center B cells. In contrast to most other lymphomas, the malignant cells usually represent only a small minority (0.1% to 2%) of the total cellular population of involved…
Definition The World Health Organization (WHO) recognizes nodular lymphocyte–predominant Hodgkin's lymphoma (NLPHL) as a separate entity distinct from classical Hodgkin's lymphoma (CHL) in the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. This reflects the fact that there are…
Plasma Cell Neoplasms Definition The plasma cell neoplasms and related disorders are clonal proliferations of immunoglobulin (Ig)-producing plasma cells or lymphocytes that make and secrete a single class of Ig or a polypeptide subunit of a single Ig that is…
This chapter reviews two aggressive large B-cell lymphomas composed of large cells with a predominant immunoblastic or plasmablastic morphology and the immunophenotype of plasma cells. Despite sharing these morphologic and immunophenotypical features, one of them, plasmablastic lymphoma (PBL), occurs in…
Burkitt's Lymphoma Denis Burkitt is credited with the pioneering work that led in 1958 to the first description of the clinical features of this unique tumor, the delineation of its geographic distribution, and the introduction of novel treatment protocols with…
Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma. In contrast to indolent (low-grade) lymphoma, the survival curve typically shows an initial downward slope followed by a plateau, indicating the potential curability of a significant proportion of patients who achieve…
Definition In the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, the World Health Organization defines mantle cell lymphoma (MCL) as a mature B-cell neoplasm generally composed of monomorphic small to medium-sized lymphoid cells with irregular nuclei that carries…