Hematology: A Pathophysiologic Approach

Key points Red blood cell (RBCs) production is stimulated by erythropoietin (EPO), a secreted glycoprotein produced by renal peritubular cells in response to hypoxia. EPO binds to EPO receptor-bearing erythroid colony-forming unit cells in the marrow, inducing proliferation, maturation, and…

Key points Hematopoiesis begins in the embryonal yolk sac and aorto-gonado-mesonephros (AGM), migrates to the fetal liver and spleen, and then moves to the bone marrow by birth. The nonhematopoietic marrow stroma provides a microenvironment conducive to growth and differentiation…

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