Gynecologic and Obstetric Pathology

Endometrial Intraepithelial Neoplasia (Atypical Hyperplasia)

D efinition — A premalignant clonal expansion of altered endometrial glands. Clinical Features Epidemiology Endometrial intraepithelial neoplasia (EIN) is relatively common and carries an increased risk of development of type 1 endometrial adenocarcinoma. Women with excess estrogen (whether exogenous or…

Ablation Artifact

D efinition — Morphologic changes secondary to medical therapy that destroys the endometrial lining. Clinical Features Epidemiology Seen in patients who undergo endometrial ablation for dysfunctional uterine bleeding. You’re Reading a Preview Become a Clinical Tree membership for Full access…

Perforation

D efinition — Perforation of the uterus, usually during endometrial sampling. Clinical Features Epidemiology Perforation is a rare complication of endometrial sampling. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited articles Become membership…

Exfoliation Artifact

D efinition — A preservation artifact in the endometrial epithelium leading to epithelial discohesion and exfoliation. Clinical Features Epidemiology Exfoliation artifact has been noted in association with hysteroscopic biopsies secondary to fluid instillation during the procedure. You’re Reading a Preview…

Submucosal Leiomyoma

D efinition — Attenuation of the functionalis due to compressing smooth muscle tumor. Clinical Features Epidemiology Similar to uterine leiomyomas. Frequently associated with uterine polyps. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…

Tubercular Endometritis

D efinition — Infection of the uterus (endometrium) by Mycobacterium tuberculosis . Clinical Features Epidemiology Involvement of the uterus by tuberculosis (TB) is exceedingly rare, due to modern treatment. Patients with uterine involvement often have systemic (or miliary) disease. Uterine…

Pyometra

D efinition — Extensive necroinflammatory debris within the uterine cavity. Clinical Features Epidemiology Overall rare (0.1% to 0.5% of women) but more commonly occurs in postmenopausal women. Associated with a wide range of disorders, including cervical stenosis, leiomyomata, retained IUD,…

Pseudoactinomycotic Radiate Granules

D efinition — Granular material that may be found in association with intrauterine devices. Clinical Features Epidemiology The finding of granular material associated with intrauterine device (IUD) use is not uncommon, happening in slightly less than 10% of patients. To…

Chronic Endometritis

D efinition — Chronic inflammatory process within the uterus often associated with infection. Clinical Features Epidemiology Chronic endometritis (CE) is thought to represent an infectious process. CE is strongly associated with the presence of pelvic inflammatory disease and acute salpingitis.…

Adenomyomatous Polyp

D efinition — An endometrial polyp composed of benign smooth muscle and glands. Clinical Features Epidemiology Adenomyomatous polyps are a variant of endometrial polyp with smooth muscle differentiation. They are often found in association with conventional polyps. You’re Reading a…