D efinition — A form of atypia associated with abnormal bleeding. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades. You’re Reading a Preview Become a Clinical Tree membership for Full access and enjoy Unlimited…
D efinition — A form of hobnail atypia associated with adjacent necrosis or hyaline degeneration signifying regional ischemia. Clinical Features Epidemiology Most commonly occurs in women in their fifth to seventh decades who have endometrial polyps. You’re Reading a Preview…
D efinition — An early, noninvasive form of serous adenocarcinoma of the endometrium. Clinical Features Epidemiology Serous endometrial intraepithelial carcinoma (EIC) is a rare neoplasm. The vast majority of patients are postmenopausal. EIC is most commonly seen in a background…
D efinition — Epithelial proliferations with evidence of p53 mutations that do not fulfill the criteria for intramucosal carcinoma. Clinical Features Epidemiology These lesions are rare and occur around menopause. Occasionally seen in endometrial polyps. Link between p53 positive epithelium…
D efinition — Nonepithelial cells present during both benign and neoplastic conditions. Clinical Features Epidemiology/Significance Histiocytes are common in postmenopausal endometrial samples, often associated with surface injury or erosion. They do not confer an increased risk of malignancy. Foamy stromal…
D efinition — Implants of keratinous material within the peritoneal cavity causing an associated granulomatous response. Clinical Features Epidemiology Overall, peritoneal keratin granulomas are an uncommon finding; however, they most commonly occur in patients with gynecologic tumors. The most common…
D efinition — A diagnostic conundrum influencing management and outcome. Presentation Abnormal uterine bleeding or postmenopausal bleeding is the most common presenting sign. Increased age at the time of postmenopausal bleeding is associated with increased incidence of carcinoma. The risk…
D efinition — Detecting abnormalities in immunohistochemical expression of mismatch repair proteins to identify patients at risk of harboring germline mutations in these genes (i.e., Lynch syndrome). Clinical Features You’re Reading a Preview Become a Clinical Tree membership for Full…
D efinition — Adenocarcinoma arising in the lower uterine segment (LUS). Clinical Features Epidemiology Uncommon variant of endometrial adenocarcinoma, accounting for from 3% to 6%. Associated with Lynch syndrome in up to 29% versus approximately 2% of conventional endometrial adenocarcinoma.…
D efinition — Adenocarcinoma of the endometrium that maintains some histologic features of normal endometrium. Clinical Features Epidemiology Endometrioid endometrial carcinoma (EMCA) is the most common form of gynecologic malignancy. The overall lifetime incidence is between 2% and 3%. The…