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Acknowledgments The authors are grateful to their NYU Langone Medical Center colleagues Matija Snuderl, MD, for contributing illustrated cases of cytogenetics analysis and methylation array; Cyrus Hedvat, MD, PhD, for providing an illustrated case of loss of heterozygosity analysis; and…
The cellular origin of glioblastoma is complex. Despite decades of research, the understanding of the cellular, molecular, and pathogenetic architecture of this lethal disease is still evolving. Other chapters discuss the epidemiology, risk factors, associated clinical outcomes, and molecular targeting…
Incidence of glioblastoma Gliomas are the most common type of malignant brain tumor in adults. Of the gliomas, glioblastoma (astrocytoma grade IV) is the most common, and represents approximately 27% of all primary brain tumors, and 80% of malignant primary…
Glioblastoma remains a formidable pathologic entity. Without the tools necessary to make a neurologic diagnosis, early medical and surgical clinicians were likely not only puzzled but also appalled by the downward trajectory of patients affected by this tumor. The development…