Diagnosis and Treatment of Rare Gynecologic Cancers

Uterine serous carcinoma

Clinical case A 64-year-old female presents to the Gynecologic Oncology clinic for a second opinion regarding a new diagnosis of uterine serous carcinoma. She originally presented to her gynecologist within the last 3 months complaining of postmenopausal vaginal spotting. Pelvic…

Uterine carcinosarcoma

Clinical case A 75-year-old African American woman presents to your clinic with complaints of new onset vaginal bleeding. She has a past medical history significant for obesity and history of breast cancer managed with tamoxifen maintenance. On pelvic exam, she…

Uterine leiomyosarcoma

Clinical case A 59-year-old nulliparous woman with history of multiple uterine fibroids status post myomectomy for abnormal uterine bleeding 20 years prior and recent total abdominal hysterectomy and salpingo-oophorectomy for recurrent, intermittent postmenopausal bleeding presented for management of pathological diagnosis…

Other rare ovarian cancers: Transitional cell carcinoma, malignant Brenner tumor, endometrioid carcinoma, mesothelioma, squamous cell carcinoma, sarcoma

Introduction Ovarian cancer encompasses a wide variety of tumors, all with different clinical patterns, histologies, and molecular features. Ovarian cancer is typically classified as epithelial (serous, mucinous, endometrioid, clear cell, carcinosarcoma, and mixed) vs nonepithelial (germ cell and sex cord…

Low-grade serous ovarian cancer

Clinical case A 36-year-old, G1P1, previously healthy woman presents with left sided pelvic pain. She presents to her PCP who performs a CBC and comprehensive panel that are unrevealing, abdominal exam shows bloating without point tenderness. She has a history…

Mucinous ovarian carcinomas

Clinical case A 34-year-old female presents with worsening abdominal distension. She is found to have a 22 cm solid and cystic pelvic mass likely arising from the right ovary on MRI, and no evidence of metastatic disease ( Fig. 5.1…

Ovarian clear cell carcinoma

Clinical case Forty-year-old G1P1 presented to her local emergency department with back pain. A CT scan showed a 14 cm right ovarian cyst, and CA-125 was elevated at 49 U She underwent a robotic-assisted laparoscopic right salpingo-oophorectomy, with surgical findings…

Ovarian carcinosarcoma

Clinical case A 76-year-old female presents with vague abdominal pain, increased abdominal girth, and early satiety over the past 3 months. On physical exam, she was noted to have abdominal distension, right lower quadrant tenderness on palpation, and a fixed…