Synonyms ▪ Fogo selvagem: endemic pemphigus foliaceus; Brazilian pemphigus ▪ Pemphigus erythematosus: Senear–Usher syndrome ▪ IgA pemphigus: intercellular IgA dermatosis; intraepidermal neutrophilic IgA dermatosis; intercellular IgA vesiculopustular dermatosis ▪ Paraneoplastic pemphigus: paraneoplastic autoimmune multi-organ syndrome Key features ▪ Pemphigus is…
Synonyms ▪ Bullous pemphigoid antigen 1: BP230 ▪ Bullous pemphigoid antigen 2: BP180; type XVII collagen ▪ Laminin 311: laminin 6 ▪ Laminin 332: laminin 5; epiligrin; kalinin; nicein; GB3 antigen; BM600 ▪ Laminin 511: laminin 10 ▪ Type VII…
For decades, the specific dermatoses of pregnancy represented a confusing group of overlapping entities, understood largely through anecdotes and case reports. However, more recent reviews have simplified and condensed the list of pregnancy-specific dermatoses ( Table 27.1 ) . For…
The neutrophilic dermatoses constitute a heterogeneous but linked spectrum of diseases , with significant overlapping histopathologic findings and similar pathogenic mechanisms and therapeutic approaches. They are often associated with underlying internal diseases, which may have significant morbidity and mortality. Histologically,…
Key features ▪ Eosinophil infiltration of the skin is commonly observed and therefore clinicopathologic correlation is required to determine a correct diagnosis ▪ Eosinophil-associated dermatoses include arthropod bite reactions and drug eruptions (“bugs and drugs”), as well as parasitic infections,…
Key features ■ Cutaneous signs of vasculitis are a reflection of the size of the vessels involved ■ Vasculitis can be limited to the small vessels of the skin or it can be a sign of life-threatening internal organ involvement…
Introduction The differential diagnosis of microvascular syndromes involving the skin is extensive and it is critical to distinguish between inflammatory injury and non-inflammatory occlusive injury to vessels. The diagnosis of occlusive syndromes in the skin is greatly facilitated by recognizing…
Purpura Introduction The differential diagnosis of purpura is extensive, but the evaluation of a patient with purpura can be greatly facilitated by categorizing purpuric lesions into morphologic subsets . The number of lesions and their distribution pattern should also be…
Key features ▪ The skin is one of the most common targets for adverse drug reactions ▪ To determine the cause of the eruption, a logical approach based on clinical characteristics, chronologic factors, and a literature search is required ▪…
Erythema Multiforme Synonym ▪ Erythema multiforme minor – erythema multiforme von Hebra Key features ▪ A self-limited but potentially recurrent disease ▪ Abrupt onset of papular “target” lesions, with the vast majority of lesions appearing within 24 hours ▪ Two…