Introduction The classification of bone sarcomas is still today mainly based on the comparison of histological, clinical, and radiological criteria. This classification evolves with the improvement of knowledge on the mechanisms of carcinogenesis of these tumors which results in the…
Research highlights Recurrent genomic rearrangements and specific somatic mutations in bone tumors are leading to new diagnostic tests. Deregulated fusion transcription factors are revealing how epigenomic changes may underlie Ewing's sarcoma oncogenesis. Deep sequencing studies have contributed toward improved understanding…
Introduction After the discovery of the Philadelphia chromosome in patients with chronic myeloid leukemia [ ], investigators in the cancer field tried to find other associations between chromosomes and cancer, including bone tumors [ ]. The cytogenetic findings of bone…
Acknowledgments K.P. is supported by European Research Council Advanced Investigator Grant “INJURMET”; C.A-P. is supported by the National Institute of Cancer (INCa, ) and SIRIC Montpellier Cancer Grant INCa_Inserm_DGOS_12553; K.P. and C.A-P. are both supported by the ERA-NET TRANSCAN…
Bone sarcoma malignancies: origin, treatment, and diagnosis Bone sarcomas are rare, highly heterogeneous oncologic entities that originate in mesenchymal tissues from bone. Primary bone cancers account for less than 0.2% of all cancers. The high morphological heterogeneity of cancer cells…
Research highlights lncRNAs promote tumorigenesis, chemotherapeutic resistance, and metastasis in bone sarcomas. Notable examples include MALAT1, TUG1, XIST, NEAT1, SNHG12, and UCA1. lncRNAs have emerged as promising diagnostic and prognostic biomarkers, as well as veritable therapeutic targets in bone sarcomas.…
Introduction Cancer metastasis occurs when cancer cells from a primary tumor spread to distant organs, with bone being one of the most common sites for breast, prostate, and lung cancers [ ]. Patients with secondary bone tumors usually show osteolytic…
Introduction Breast cancer and prostate cancer are the most frequently diagnosed cancers of women and men, respectively, living in developed countries with more than 1 million new cases per year worldwide. Despite the progresses made in the development of new…
Research highlights The epigenome defines cellular identity and is frequently dysregulated in primary bone cancers Aberrant epigenetic modifications in these cancers are promising drug targets Epigenetic heterogeneity is a characteristic of primary bone cancers Novel technologies for analyzing epigenetic heterogeneity…
Abbreviations BAP Serum bone alkaline phosphatase BMD Bone mineral density BSP Bone sialoprotein CTX-I Epitope of C-terminal cross-linked telopeptide of collagen type I DPD Deoxypyridinoline ICTP Epitope of C-terminal cross-linked telopeptide of collagen type I LSC Least significant change MGUS…