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Travel health issues for women will vary according to the life stage and lifestyle of the women. Issues differ depending on whether the woman is in her second trimester of pregnancy or about to go on her first solo journey at age 80. To adapt the standard pre-travel health recommendations to the needs of a female traveler, one needs to consider potential gender- and age-related issues with regard to susceptibility and long-term sequelae of parasitic and other infectious diseases, safety of immunizations during pregnancy, and adaptation of the medical kit for health concerns relevant to the life stage of the woman. Other gender-related issues that may be important relate to environmental risks, such as altitude or climate, and sports-related concerns.
Gender-related issues in travel and tropical and wilderness medicine are important to consider when we counsel female travelers regarding possible risks of disease before travel. For example, are the immunizations and medications recommended for a specific itinerary contraindicated in pregnancy? Can a woman on estrogen replacement trek safely over an 18,000-ft pass? What is a woman's risk of female genital schistosomiasis and future infertility if she is a Peace Corps volunteer working on a water conservation project for 2 years in a country endemic for schistosomiasis?
In 2001, the Institutes of Medicine released a landmark report that studied the basic biochemical differences in the cells of males and females as well as the health variability between the sexes from conception throughout life. The report confirmed the differences between the sexes in the prevalence and severity of a broad range of diseases, disorders, and conditions. In 2004, the Society for Women's Health Research persuaded the US Congress to include language in a 2005 appropriations bill demanding the National Institutes of Health to “include sex-based biology as an integral part” of all medical research.
Although there is a growing body of research in developed countries with regard to the interrelationships between gender and health, few studies in developing countries have focused on gender differences with regard to the biomedical, social, or economic impact of tropical diseases, much less their impact at the personal level. For this reason, the World Health Organization (WHO) section of Tropical Diseases Research formed the Gender and Tropical Disease Task Force to stimulate research on gender determinants and consequences of tropical disease. The focus of WHO is on women living in endemic countries. We also need to consider the possible gender-related effects of tropical disease on female travelers living in endemic areas for extended periods and/or female adventure travelers involved in high-risk activities.
For many diseases endemic to the developing world, differences between female and male prevalence rates in indigenous people are difficult to measure, as cases in women are more likely to be undetected. When incidence rates in women and men are equal, there are still significant differences between the sexes in both the susceptibility and impact of tropical disease. Even when tropical diseases are shared by both sexes, they may have different manifestations, natural histories, or severity. For example, exposure to malaria is similar in women and men, with a slightly higher incidence in men. Biologically, however, a woman's immunity is compromised during pregnancy, making her more likely to become infected and implying a different severity of the consequences. Malaria during pregnancy is an important cause of maternal mortality, spontaneous abortion, and stillbirths.
Similarly, both sexes are susceptible to schistosomiasis, but genital schistosomiasis in women has been associated with a wide range of pathobiologic manifestations such as infertility, abortion, and preterm delivery. Thus physicians may be confronted more often with parasitic infections causing infertility, not only in patients originating in tropical countries but also in Western women as a result of a tendency to travel and work in exotic and subtropical countries.
Further research is needed to clarify the general question of sex differences in susceptibility and differential severity of the sequelae of tropical infectious diseases. These issues are important when we advise women on pre-travel issues, especially the long-term or adventure traveler. Knowledge of gender-specific risks for tropical disease is also important when we evaluate returned female travelers and recent female immigrants for health problems related to their history of travel and/or living in countries endemic for tropical diseases.
Basic questions related to health include the following: What is the woman's reproductive stage of life? Is she using contraception? Is her contraceptive method appropriate for her travel itinerary? Does she have emergency contraception? Is she prepared to treat the usual women's health problems, such as urinary tract infections (UTIs), vaginitis, and menstrual cramps? Is she pregnant, planning to get pregnant, or breast feeding? If menopausal, does she have estrogen replacement therapy or herbal medications for symptoms? A format for obtaining a pre-travel health history for women is given in Table 14.1 .
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Women travelers, especially those embarking on adventure travel itineraries or planning extensive travel abroad, may find it beneficial to augment the basic travel medical kit (see Chapter 1 ) with supplies and medications specific to a given woman's life stage and reproductive health. Table 14.2 lists items that might be included in a travel medical kit for women, and Table 14.3 provides some Internet resources for further information on health issues of women travelers.
|
Website | ||
---|---|---|
Contraception | ||
International Consortium for Emergency Contraception | www.cecinfo.org/ www.cecinfo.org/country-by-country-information/status-availability-database/ |
Emergency contraception options worldwide |
Emergency contraception options | http://ec.princeton.edu/worldwide/ | Information about emergency contraception and what is available worldwide, searchable by country |
International Planned Parenthood | http://www.ippf.org/ www.ippf.orgwww.contraceptive.ippf.org/ |
Information on contraceptive methods available worldwide, searchable by composition, brand name, type, manufacturer |
Contraceptive technology | www.contraceptivetechnology.org/ | Resource on contraceptive technology |
Sexual health | http://www.cdc.gov/sexualhealth/ | |
Information for women travelers on issues related to sexual health and contraceptive options worldwide | ||
HIV post-exposure prophylaxis | http://nccc.ucsf.edu/ http://nccc.ucsf.edu/clinician-consultation/pep-post-exposure-prophylaxis/ http://nccc.ucsf.edu/clinical-resources/pep-resources/pep-quick-guide/ |
Non-occupational PEP guidelines; PEP hotline 888-448-4911 |
Pregnancy | ||
Pregnant traveler | www.pregnanttraveler.com | Resource for clinicians and pregnant travelers |
Lactation | ||
Thomas Hale | http://neonatal.ttuhsc.edu/lact/ | Resource on issues relating to breast feeding and medication use |
International Lactation Association | http://gotwww.net/ilca/ | Resource for an international lactation consultant for women |
Evacuation insurance | ||
International SOS | www.internationalsos.com | |
MEDEX | www.medexassist.com | |
Travel kit | ||
Female urinary directors | www.freshette.comwww.travelmateinfo.comwww.traveljohn.com | Options for female urinary directors |
Menstrual supplies | www.divacup.com/www.keeper.com/www.softcup.com/www.gladrags.com/ | Reusable menstrual products for travel |
Travel guide for women | http://travel.gc.ca/travelling/publications/her-own-way | Travel information for women travelers throughout the lifespan |
Women between 12 and 55 years old menstruate, on average, once a month, with a high degree of variability among women. During travel, a woman should be prepared for either the worst menstrual period of her life with more cramping and more bleeding than usual or for her periods to actually cease. Menses may cease or become irregular during travel for a number of reasons other than pregnancy. For example, the mere stress of traveling, including changes in sleep patterns, diet, activity, illness, and time zones, can easily disrupt a woman's menstrual cycle. Recommendations can be made regarding measures to take depending on whether she uses oral contraceptives, her previous history, and the result of a self-pregnancy test. A woman should be warned that just because she is not menstruating while traveling does not mean she is not ovulating. She still needs a method of contraception to prevent unplanned pregnancy. Self-pregnancy tests are also important in the evaluation of a sexually active woman of reproductive age to help determine whether her abdominal pain and/or abnormal vaginal bleeding could be related to a pregnancy.
It is important to carry sufficient disposable sanitary napkins or tampons, since they are not available in many countries. Menstrual cups are another option. There are also reusable tampons made out of sea sponges and a variety of washable pads. Reusable products are ideal for the environmentally concerned backpacker and the long-term traveler. Pre-moistened towelettes for personal hygiene and plastic bags to dispose of sanitary supplies are also useful.
Some women prefer not to have a menstrual cycle while traveling. One option to control the menstrual cycle is through the use of a hormonal contraceptive method, such as the combined oral contraceptive pill, patch, or vaginal ring. By skipping the “hormone free” week and continuing the active hormone component (pill, patch, or ring) as directed, no withdrawal bleeding occurs, until the woman is ready to stop the active hormone and get withdrawal bleeding.
Medication for menstrual cramping and other symptoms of premenstrual syndrome should also be carried in the medical kit ( Table 14.2 ).
Women are prone to UTIs during travel as a result of multiple factors, including dehydration, less frequent urination because of a lack of convenient toilets, fewer available facilities for hygiene, an increase in sexual activity, and other changes in exercise, diet, and clothing. Preventive measures include instructions for female travelers to stay well hydrated and to urinate wherever there is convenient access to a public toilet whether or not the bladder is full.
A number of plastic and paper funnel devices have been designed so that a woman may urinate in the standing position. Another option to try for a cold night in a tent or when there is no bathroom facility is a “portable john.” This is a unisex funnel that empties into a biodegradable plastic bag with biodegradable filler that turns the urine into a solid so it will not spill. The personal urinal bags can be used until full (800 cc or 28 oz), then disposed of.
To maintain hygiene, it is important to carry a supply of paper tissues or toilet paper and some packets of pre-moistened towelettes in a fanny pack or backpack. If an older woman is experiencing vaginal dryness and urinary frequency or urgency without dysuria, recent data suggest that estrogen vaginal creams, a vaginal ring, or even an oral contraceptive pill intravaginally once a week may decrease urogenital dryness and frequency symptoms. Vaginal moisturizers (e.g., Replens) can also be used. If a woman experiences increased frequency, urgency, and dysuria, she should be advised how to diagnose and treat herself for a UTI with an antibiotic and an analgesic.
If an older woman has a problem with stress incontinence or bladder control, she should consult with a physician specializing in female urinary tract problems in advance of the anticipated trip. For minor problems, a woman can be taught to do Kegel exercises and should bring a supply of panty liners.
Women are at risk for vaginitis during travel, secondary to many of the same reasons as for UTI. One of the most common causes of vaginitis is Candida albicans. This organism usually causes a thick cottage cheese-like white discharge with vulvar and vaginal itching. The risk of yeast vaginitis may be greater if doxycycline is used for malaria chemoprophylaxis or if other broad-spectrum antibiotics are used for the treatment of traveler's diarrhea or other medical problems.
Several topical preparations against yeast are available over the counter, including nystatin, miconazole, and clotrimazole vaginal creams or troches. Prescriptions for resistant cases can be recommended, such as tetrazole vaginal cream (3 days) or fluconazole (150 mg as a single oral dose). Many women prefer to use the oral medication, as the vaginal creams can be messy during travel. Other women feel the vaginal creams help with the symptoms of itching. A hydrocortisone cream may also be used if needed for vulvar itching. Any persistent symptoms should be evaluated by a gynecologist when returning home. Even if a woman has never had vaginitis, it is important to prepare her for the possibility, especially for extended travel.
Another common cause of vaginal discharge is bacterial vaginosis. This is caused by overgrowth of the bacteria in the vagina, which can be due to many of the same causes listed previously. The discharge is usually more of a grayish color with a fishy odor. Bacterial vaginosis is treated with metronidazole tablets taken orally or clindamycin vaginal cream applied topically. If a female traveler develops a discharge and pelvic pain after a new sexual encounter, she may have a sexually transmitted disease and should follow the recommendations discussed in Chapter 41, Chapter 42, Chapter 43, Chapter 44 .
Contraceptive advice should be included in the pre-travel counseling for all women of reproductive age at risk for pregnancy. It should also be included in the pre-travel counseling for men who might put women at risk for pregnancy. This is especially important if the man's partner might be in a country where she might not have easy access to contraception.
Women may become pregnant as a result of a lack or misuse of contraception, and women travelers are no exception. In the United States, over 50% of pregnancies are unplanned. If a woman is already using contraception, the method should be evaluated for its ease of use and reliability during travel along with any special recommendations concerning its use during travel. If a woman wishes to try a new contraceptive method, ideally she should begin months before travel, especially if she is planning to be overseas long-term or will be living in a remote area. Back-up plans for what the woman should do if she loses her present method should be discussed. The International Planned Parenthood Federation (IPPF) keeps a worldwide guide to contraceptives and an address list of family planning agencies available on the Web ( Table 14.3 ).
Women should be advised to take extra supplies of their oral contraceptives with them, since it may be difficult to find the identical brand in another country. It may be difficult to remember to take an oral contraceptive pill when traveling because of changes in time zones and schedule. However, keeping on schedule is especially important for women taking the low-dose combined and progestin-only pills. It is advised that women on such regimens consider wearing a special wristwatch with alarm, dedicated to signaling when the 24-hour scheduled oral contraceptive dose is due, or to download one of the smartphone apps available to help remember medication dosing.
Another problem is pill absorption during illness. Nausea and vomiting and/or diarrhea may cause decreased pill absorption. If vomiting occurs within 3 hours of taking a pill, the woman should take another one. If nausea and vomiting and/or diarrhea are persistent, the woman should consider using another contraceptive method for the rest of the month. Another option might be to insert the oral contraceptive pill in her vagina for absorption. A number of studies have demonstrated vaginal absorption of hormones in either the pill or the ring form as a method of contraception or estrogen replacement. A woman might choose the contraceptive patch or vaginal ring as a good alternative contraceptive method for travel.
A big concern among women travelers taking oral contraceptives is whether antibiotics affect oral contraceptive efficacy. Antibiotics have been shown in animal studies to kill intestinal bacteria responsible for the deconjugation of oral contraceptive steroids in the colon. Without such deconjugation and subsequent reabsorption, decreased hormone levels may result, leading to a decrease in hormone efficacy. Despite numerous case reports of penicillins, tetracyclines, metronidazole, and nitrofurantoin causing contraceptive failure in humans, no large studies have demonstrated that antibiotics other than rifampin lower steroid blood concentrations.
To date, there are no known drug interactions between oral contraceptives and malaria chemoprophylaxis such as atovaquone/proguanil and mefloquine. Doxycycline and other broad-spectrum antibiotics temporarily reduce colonic bacteria, thus inhibiting the enterohepatic circulation of ethinyl estradiol. The importance of this effect on the enterohepatic circulation varies from woman to woman. This is not thought to be clinically significant, and a back-up method of contraception is not routinely recommended. A more conservative approach would be to recommend a back-up method of contraception for the first 3 weeks a woman is taking both doxycycline and oral contraceptives. If the hormone-free week occurs during this time, she should continue her contraception with a new package of hormonally active pills so as not to let her blood levels fall. After 3 weeks, the enterohepatic circulation should be restored and the back-up method of contraception stopped.
The potential for being or becoming a pregnant traveler exists for most women of reproductive age. Contraceptive failures are common. Condoms break, diaphragms slip, oral contraceptives may be missed due to changes in time zones, or malabsorption of the pill may occur as a result of vomiting and diarrhea. The contraceptive method could also be lost or stolen. A woman may experience a rape or assault.
Emergency contraception (EC) is defined as a method of contraception that a woman can use after unprotected intercourse to prevent pregnancy. For maximum effectiveness EC treatment should be started as soon as possible after unprotected intercourse. Treatment is most effective if initiated within the first 12-24 hours and definitely within 120 hours. Thus it is important for the travel medicine clinician to include a recommendation for emergency contraception for all women who may be at risk for pregnancy and/or how to access EC.
Ulipristal acetate (Ella) was approved by the US Food and Drug Administration (FDA) in 2010 and is the most effective EC pill. It is a progesterone receptor modulator and is effective for up to 5 days after unprotected intercourse. It is available by prescription or on the Web. In Europe it is known as ellaOne.
The easiest method for a female traveler to obtain is Plan B, consisting of two tablets of levonorgestrel (750 µg). Plan B is approved by the FDA for over-the-counter sale. Other options for EC include regimens using progestin-only mini- or low-dose pills to provide a dose comparable to the branded Plan B product or using regular oral contraceptives containing ethinyl estradiol and either norgestrel or levonorgestrel ( Table 14.4 ). Recent data suggest that the progestin-only EC treatment (two tablets of 750 µg levonorgestrel taken together as one dose) is more effective and causes less vomiting than does treatment with combined estrogen-progestin tablets (100-120 µg ethinyl estradiol and 500-600 µg levonorgestrel in each dose). Nausea and vomiting are common with the combined pill regimen, so antiemetic tablets may be prescribed to be taken 30 min before the second dose of oral contraceptive. Mifepristone (RU-486) is an antiprogesterone drug that can be used for EC in lower doses than used for medical abortion. It prevents the release of an egg from the ovary and makes the uterine lining inhospitable to implantation. Studies have shown it to be more effective, safer, and with fewer side effects than either levonorgestrel or the combined pill regimen. It is available in Europe and China.
Brand | First Dose | Second Dose (12 h later) | Ulipristal Acetate per Dose (mg) | Ethinyl Estradiol per Dose (µg) | Levonorgestrel per Dose (mg) |
---|---|---|---|---|---|
Ulipristal Acetate Pills | |||||
Ella | 1 white pill | None | 30 | ||
Progestin-only pills | |||||
Levonorgestrel | 2 white pills | none | 1.5 | ||
Plan B one step | 1 white pill | none | 0 | 1.5 | |
Combined estrogen and progestin pills | |||||
Levora | 4 white pills | 4 white pills | 120 | 0.60 | |
Lo/Ovral | 4 white pills | 4 white pills | 120 | 0.60 | |
Nordette | 4 light orange | 4 light orange | 120 | 0.60 | |
Seasonal | 4 pink pills | 4 pink pills | 120 | 0.60 |
Worldwide, there is great variability in the availability of EC. If a woman loses her prescription or it is stolen, it would be important to advise her of the methods that might be available in the areas she is traveling. The Emergency Contraception Website ( http://ec.princeton.edu/ ) has information on EC methods and a searchable database for options available worldwide. There also is an Emergency Contraception 24-hour hotline (1-888-NOT-2-LATE). If a traveler becomes pregnant and wishes to terminate the pregnancy, it may be best for her to return home. More than half of the 128 countries listed by the IPPF prohibit abortion except in extreme circumstances, such as rape and life-threatening illness.
Sexually transmitted infections (STIs) are of special importance to women due to gender-related pathophysiology that leads to an increased rate of transmission from an infected male to an uninfected female. In addition, women suffer more serious sequelae from a sexually transmitted disease, such as pelvic inflammatory disease or infertility, than do men.
To prevent STIs, one should avoid casual sex or practice safe sex by using condoms, regardless of concomitant use of another method of birth control. High-quality latex condoms are an essential part of the personal medical kit of adult travelers, regardless of gender and whether or not sexual activity during travel is planned or unplanned. A female condom made out of polyurethane is an effective alternative for persons allergic to latex. Travelers may be provided with an information card or sheet summarizing STI signs and symptoms for use in self-diagnosis and possible treatment if remote from professional medical care. One resource is the sexual health website at the Centers for Disease Control and Prevention (CDC; www.cdc.gov/sexualhealth/ ). Women travelers should be informed about the availability of antiretroviral drugs and their use in post-exposure human immunodeficienty virus (HIV) prophylaxis (termed non-occupational post-exposure prophylaxis [NPEP]) following a high-risk sexual exposure or sexual assault. The rate of HIV transmission from an infected male to an uninfected female is estimated to be equivalent to a high-risk needle stick. Thus, NPEP should be started preferably within 1 hour and no later than 72 hours after a high-risk exposure.
In certain cases, a woman traveler may be given an NPEP “starter kit” of a 3- to 5-day supply of antiviral drugs. This can be used in an emergency until the situation can be further evaluated and/or more medication can be obtained. As the drugs can be associated with significant adverse effects, ongoing NPEP treatment should be administered under medical supervision. These medications are not available in most developing countries.
Women taking oral contraceptives may continue them at moderate altitudes (<3600 m, or 12,000 ft), since the risk of pregnancy may be greater than the risk of thrombosis. Women on oral contraceptives have a higher risk of deep vein thrombosis (DVT)/pulmonary embolism (PE) at any altitude, estimated to be about 5/100,000. Pregnancy increases the risk of DVT/PE 12-fold to about 60/100,000. Women on oral contraceptives should be advised to consider other contraceptives for extended stays at very high altitudes (>5500 m), because of a theoretical increased risk of thrombosis and PE.
Pregnant women of all ages and at all stages of pregnancy travel for business, professional, and personal reasons. First, the past medical and obstetric history should be reviewed with the woman in conjunction with her obstetrician ( Table 14.5 ). Travel during the last month of pregnancy and travel that may pose a serious risk to the mother or the fetus should be avoided. Possible risk factors and potential contraindications to travel are listed in Table 14.6 . If a woman has had a previous adverse pregnancy outcome or has had a difficult time becoming pregnant and is in her late 30s or 40s, she should weigh the possible risks with particular caution.
Step | Content |
---|---|
History | Review past medical and past obstetric and gynecologic history |
Physical examination | Obstetrician to assess gestational age, fetal growth performance, coexistent medical, obstetric, social, and demographic risks |
Laboratory tests | Ultrasound |
Serology for hepatitis A and B, E, CMV, measles, rubella, varicella, and toxoplasmosis, depending on history | |
Review planned itinerary |
|
Specific recommendations |
|
Absolute contraindications | Relative contraindications |
---|---|
Abruptio placentae | Abnormal presentation |
Active labor | Fetal growth restriction |
Incompetent cervix | History of infertility |
Premature labor | History of miscarriage or ectopic pregnancy |
Premature rupture of membranes | Maternal age <15 or >35 |
Suspected ectopic pregnancy | Multiple gestation |
Threatened abortion, vaginal bleeding | Placenta previa or other placental abnormality |
Toxemia, past or present | Medical conditions: heart disease, diabetes, lung disease, thrombosis, kidney disease, other systemic illnesses |
Destination risk considerations | Postpone travel if risks outweigh benefits. |
Malaria | |
Outbreak of disease requiring live vaccine | |
Outbreak of a disease for which no vaccine is available but there is a high risk of fetal and maternal morbidity | |
Medical services during transit and at destination | |
Environmental risk considerations: altitude, heat, water, other |
The complete itinerary should be evaluated with attention to the quality of medical care possible both during transit and at the final destination. Access to high-quality care during travel is essential in case of pre-term labor or an unexpected complication of pregnancy. The itinerary should also be reviewed for possible risks of exposure to certain infections, for example, chloroquine-resistant Plasmodium falciparum malaria, hepatitis E, typhoid, amebiasis, influenza, polio, and yellow fever, as these travel-associated diseases may have more severe or even fatal complications in a pregnant woman because of her altered immune status during pregnancy compared with a nonpregnant individual. In addition, there are special considerations concerning the use of malaria chemoprophylactic drugs and certain immunizations during pregnancy. The potential exposure to specific health risks may be improved by adjusting certain destinations and activities on the trip route.
It is important for a woman to check her health insurance plan regarding coverage. Many plans do not cover pregnant women overseas, and many have gestation cutoff dates for travel beyond which they will not cover delivery out of the area. She may have to buy additional coverage and emergency evacuation insurance. All pregnant travelers should carry a copy of their medical records (including current gestational age, expected date of delivery, blood type and Rh, and a copy of fetal ultrasound report) in case of emergency.
Pregnant women anticipating travel to remote places need to have the following questions answered before confirming their itinerary:
What medical, obstetric, social, and demographic risks are associated with travel?
Are the required and recommended immunizations for the itinerary safe in pregnancy?
What drugs against malaria and other parasitic illnesses are safe in pregnancy?
What prophylactic or therapeutic measures against traveler's diarrhea are safe in pregnancy?
What medical services are available in the area(s) of destination?
What does her health insurance cover if she is out of area for delivery or pregnancy-related complications?
What are signs of serious pregnancy-related illness for which emergency medical help should be sought?
What are some general guidelines to follow for the medical management of illness that will safeguard the pregnant woman and her fetus?
Cultural aspects of traveling while pregnant or nursing should also be researched prior to travel. Customs vary in different cultures. Breast feeding an infant in public areas may not be allowed in some cultures.
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