Endolimax nana is a single-celled parasite of the colon. Although considered nonpathogenic, infection with E. nana is an indicator of exposure to fecal contamination and often is seen in fecal samples positive for other common parasitic intestinal protists.

Description of Endolimax Nana

E. nana is an intestinal parasitic ameba, which appears to be most closely related to Iodamoeba. , E. nana has a monoxenous life cycle ( Fig. 262.1 ), with trophozoite stages (8–10 μm) found in the colon where they move by pseudopodia, feeding exclusively on bacteria. , The trophozoite nucleus is vesicular and spherical with a polymorphic karyosome ( Fig. 262.2 ). After encystation, the oval cyst (6–9 μm × 5–7 μm) is excreted in feces, and when mature, it contains four nuclei ( Fig. 262.3 ). Mature cysts may excyst and colonize the colon when ingested. When established, the ameba may persist in the colon for ≥17 years.

FIGURE 262.1, Life cycle of Endolimax nana , Entamoeba coli , Entamoeba hartmanni , Entamoeba polecki , and Iodamoeba bütschlii .

FIGURE 262.2, Trophozoites of Endolimax nana in stool specimen.

FIGURE 262.3, Mature cysts of Endolimax nana in fecal concentrate.

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