Taking the Next Steps: Clinical Reasoning


Clinical reasoning is the process by which the information gathered from the history and physical examination is merged with clinical knowledge, experience, and the current best evidence to formulate the next steps in patient care—development of the diagnostic and management plans. Critical reflection involves thinking through the reasoning for these decisions. This reflection can help you progress from rote decision making to clinical reasoning.

The Clinical Examination

Thus far, we have been concerned with the initial patient interaction, establishment of respectful rapport, and information-gathering processes (i.e., history and physical examination). Organizing, integrating, and analyzing information comprise the next step in caring for patients. This process, called clinical reasoning, leads to the development of potential diagnoses, workup priorities, and management plans ( Box 4.1 ). Formulating management plans should occur in partnership with patients and their families. Working with the patient to determine the best course of action is often called “shared decision making” or “patient-centered care.”

BOX 4.1
Steps for Clinical Reasoning

Clinical Reasoning

Assessment, Judgment, and Evidence

Clinical reasoning involves bringing knowledge of the patient, clinical experience, and decision-making skills together with the current best evidence regarding the issues involved. The best available evidence must be carefully obtained from the volumes of information available in books, journals, and online. Use of evidence in decision making is called “evidence-based practice” ( Box 4.2 ).

BOX 4.2
Evidence-Based Practice

Evidence-based practice (EBP) incorporates best evidence, along with individual experience and patient preference, into making medical decisions (Sackett et al, 1996). EBP involves questioning physical examination findings, the effects of therapy, the utility of diagnostic tests, Disease prognosis, and/or the etiology of disorders (Sackett et al, 1996).

The first step in clinical reasoning is to assess what has been learned from the patient and to determine its value and significance. Priorities are then assigned to information that might influence clinical judgment as management plans and clinical impressions are created.

Further assessment depends on healthcare provider, patient, and family preferences, which may be influenced by feelings, attitudes, and values. By using clinical reasoning, you can think through your own beliefs, values, cultural practices, and attitudes for potential bias affecting the decision-making process. Clinical impressions help direct further assessment, which must be balanced by benefits and risk to the patient, cost considerations, and available resources. Determining the leading diagnoses, potential diagnostic, and management plans can be formulated using shared decision making.

Problem Identification

A problem may be defined as anything that will need further evaluation and/or attention. It may be related to one or more of the following:

  • An uncertain diagnosis

  • New symptoms or physical examination findings related to a previous diagnosis

  • New symptoms or findings of unknown etiology

  • Unusual findings revealed in the clinical examination or by diagnostic tests

  • Personal, social, or emotional difficulties

Formulate problems as specifically as possible. Identify and list the signs and symptoms associated with each of the patient’s concerns as well as abnormalities discovered during the physical examination. This listing of findings—the problem list—is key to developing a complete understanding of a patient’s concern. The problem list is the foundation for clinical reasoning and is used to form hypotheses based on the available information ( Box 4.3 ). Review the problem list and note the absence of findings that you might expect in support of your hypotheses. Think through the patient’s verbal and nonverbal communication and determine whether there are questions you may have neglected to ask or information you did not fully understand. Gather additional information from the patient to fill in these gaps. Beware of “red herrings”—the bits of information that are distracting and draw your thinking away from central issues ( Box 4.4 ). Critically evaluate unexpected or unusual findings, but do not let them distract you from full consideration of all you have learned.

BOX 4.3
Decision Making

There are several ways to make a diagnosis:

  • Patterns Recognition (e.g., “If it walks like a duck, swims like a duck, and quacks like a duck—it is most likely a duck”)

  • Sampling the universe (including everything precludes missing anything)

  • Using algorithms (a rigidly defined thought process precludes error)

Although each of these may have limited use in specific situations, consideration of all your findings should most often result in the development of one or more hypotheses needing an evidence-based approach to solutions.

Guidelines to a sound decision-making process include the following:

  • Always derive possibilities that are consistent with the chief concern, your findings, and known psychosocial and pathophysiologic mechanisms.

  • Remember that common problems occur commonly, and rare ones do not.

  • Common problems can have unusual presentations, and rare ones may have a seemingly common concern.

  • Rare problems that have an available treatment should be considered.

  • Do not rush to a diagnosis with no available treatment, and do not pursue a line of reasoning that will not alter your course of action. For example, if a patient cannot tolerate cancer treatment, do not peruse the screening and diagnostic evaluation.

  • Do not undertake procedures that are not related to your hypotheses.

  • Always consider potential harm and cost as well as benefit when determining the need for a test or action.

  • Consider whether the risk is worth the potential gain in information, invoking the ethical principle of nonmaleficence: Primum non nocere —“First, do no harm.”

  • Remain open in your thinking and be ready to discard or modify your hypotheses when necessary. Recognize that your leading hypotheses may not be valid and avoid the tendency to discount information that may invalidate your favorite ideas.

  • Try to have a single process explain all or most of your data, but do not be rigid in this regard. After all, a patient with many concerns and problems may have more than one Disease; two common Diseases may occur simultaneously more often than one rare Disease alone.

Probability and utility should always be your guides to sequencing your actions unless a life-threatening situation exists. A conscientious estimate of probability is the best way to define the limits of uncertainty and the best way to establish priorities.

BOX 4.4
Red Herrings

A patient with swollen cervical nodes and fever owns a cat, which had claws, but the patient did not have cat scratch Disease. The too obvious apparent source of the problem, a “red herring,” delayed the ultimate diagnosis of non-Hodgkin lymphoma.

After a match between the data (both subjective and objective) and a presumed diagnosis is made, consider the appropriate laboratory studies, imaging studies, or specialty consultation needed to confirm the diagnosis. When determining next steps, it is important to consider primacy of patient welfare, patient autonomy, and need for resource allocation. We are strong advocates for our patients and, at times, their only voice. As such, we are responsible for appropriate resources; we should make judicious choices with testing and evaluation ( Cassel and Guest, 2012 ).

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