Grade 1 spondylolisthesis without instability on flexion/extension and claudication


Introduction

Spondylolisthesis was first described by Herbiniaux, who noted the presence of a lumbar vertebrae ventral to the sacrum causing an obstruction to the progression of labor during a routine pelvic exam. The term “spondylolisthesis,” however, was not used until Kilian reported the cause of this condition due to the subluxation of the facet joint. Lumbar spondylolisthesis is described as ventral subluxation of one vertebrae body on the other. It is classified as either congenital/dysplastic, isthmic, degenerative traumatic, or pathological based on the classification of Wiltse-Newman-MacNab, which has become the most widely accepted classification system. The degree of slippage is graded based on the Meyerding, where the scale varies from grade I to V ( Table 1.1 ). Grade I spondylolisthesis is defined as slippage less than 25%, grade II is displacement up to 50%, grade III is displacement up to 75%, grade IV is displacement greater that 75%, and grade V is defined as a complete subluxation of one body on another and is also referred to as spondyloptosis.

Table 1.1
Meyerding’s grading of spondylolisthesis
Grade Description (%)
1 0–25
2 26–50
3 51–75
4 76–99
5 >100

Example case

Chief complaint: leg and back pain

History of present illness: A 77-year-old male with a history of back and leg pain for multiple years. Over the last few months, he has had worsening back pain that radiates to his buttocks and lower extremities. He also has some numbness down his lower extremities. He can stand for an extended period time but is only able to walk around 100 yards. He has tried physical therapy without significant improvement. He also underwent an epidural injection, which gave him 1 week of relief ( Fig. 1.1 ).

Fig. 1.1, Preoperative MRI. (A) T2 sagittal MRIs and (B) T2 axial MRIs demonstrating L4/5 grade I spondylolisthesis with facet degeneration and canal stenosis.

Medications: losartan, aspirin 81 mg, amlodipine, tamsulosin, simvastatin

Allergies: penicillin

Past medical and surgical history: hypertension, prostate cancer status post prostatectomy, umbilical hernia repair

Family history: noncontributory

Social history: retired engineer, no smoking history, occasional alcohol

Physical exam: Awake, alert, and oriented to person, place, and time; cranial nerves II–XII intact; bilateral deltoids/triceps/biceps 5/5; interossei 5/5; iliopsoas/knee flexion/knee extension/dorsi; and plantar flexion 5/5

Reflexes: 2+ in bilateral biceps/triceps/brachioradialis with negative Hoffman; 2+ in bilateral patella/ankle and no clonus or Babinski; sensation is intact to light touch

  • Rafid Al-Mahfoudh, MBChB

  • Neurosurgery

  • Brighton and Sussex University Hospitals

  • Brighton, United Kingdom

  • Sigurd Berven, MD

  • Orthopedic Surgery

  • University of California at San Francisco

  • San Francisco, California, United States

  • Mohamad Bydon, MD

  • Neurosurgery

  • Mayo Clinic

  • Rochester, Minnesota, United States

  • Sutipat Pairojboriboon, MD

  • Orthopedic Surgery

  • Vichaiyut Hospital

  • Phyathai, Thailand

Preoperative
Additional tests requested
  • MRI thoracic and lumbar spine

  • Anesthesia evaluation

  • Standing AP and lateral lumbar x-rays

  • Possible DEXA

Anesthesia evaluation
  • CT L-spine

  • Cardiology evaluation

  • Anesthesia evaluation

Surgical approach selected L4–5 laminectomy L4–5 TLIF MIS L4 laminectomy MIS L4–5 laminectomy
Goal of surgery Thecal sac and lateral recess decompression Decompression, stabilization Nerve root decompression Decompression, preserving lumbar motion
Perioperative
Positioning Prone on Wilson frame Prone on Wilson frame Prone Prone on Jackson table
Surgical equipment
  • Fluoroscopy

  • Surgical microscope

  • Ultrasonic bone scalpel

Fluoroscopy
  • Fluoroscopy

  • Surgical microscope

  • Tubular retractors

  • Fluoroscopy

  • IOM

  • Surgical navigation

  • Surgical microscope

  • Tubular retractors

Medications Steroids, tranexamic acid Acetaminophen, gabapentin None ERAS protocol (local anesthetic, epidural steroid, short-acting narcotics, NSAIDs)
Anatomical considerations Thecal sac, facets Thecal sac, nerve roots Thecal sac L4–5 disc space, lamina, medial facets, interlaminar space, ligamentum, thecal sac, bilateral nerve roots
Complications feared with approach chosen Spinal instability, prolonged hospital stay Nerve root injury, spinal instability Nerve root injury, spinal instability Inadequate decompression, nerve root injury, dural tear
Intraoperative
Anesthesia General General General General, ERAS
Exposure L4 L3–5 L4 hemilamina L4–5
Levels decompressed L4 L4–5 L4 L4–5
Levels fused None L4–5 None None
Surgical narrative Positioned prone, paramedian needle used to localize operative level, midline incision, unilateral muscle dissection, L4 spinous process osteotomy, McCullouch retractor, x-ray to confirm level, microscope brought in, laminectomy with electric drill, bone is thinned and remainder of lamina removed with upcuts with flavectomy, lateral recess decompression continued with up cuts or ultrasonic bone scalpel, x-ray with instruments at cranial and caudal aspect of decompression, closure in layers Positioned prone with Wilson frame elevated, expose L3–5 spinous processes, subperiosteal exposure from L3–4 to L4–5 faces with preservation of L3–4 facet, bilateral complete facetectomies at L4–5 including removal of superior articular process to the level of L5 pedicle, place L4–5 pedicle screws with x-ray to check screw placement, TLIF on more symptomatic side with banana-shaped cage for lordosis anteriorly, decorticate L4–5 transverse processes, spinal instability, arthrodesis with local bone with demineralized bone matrix, layered closure C-arm fluoroscopy for identifying level, sequential dilators are placed over the pin, extend incision as needed, dock tubular retractors on L4 hemilamina, C-arm to confirm level, hemilaminectomy at inferior aspect of L4, removal of yellow ligament, decompression of contralateral side with over the top technique, close in anatomical layers Positioned prone with Jackson frame, percutaneous reference pin placed on left ilium inferior to PSIS and set up of navigation system, intraoperative CT with O-arm and transfer images to work station, lower edge of L4–5 disc marked, paramedian to midline incision, tubular retractor inserted bluntly, visualize inferior laminar edge, navigation probe to assess area of decompression, thin bone with high-speed drill until insertion zone of yellow ligament reached, switch drill to diamond bur to minimize risk of damage to dura, remove yellow ligament after separating from dura, access ipsilateral lateral recess, begin decompression of nerve root at shoulder, undercut ipsilateral superior and inferior medial facets while using dissector and navigation to evaluate decompression, tilt table away to help decompress contralateral side, retract dura with nerve hook, remove remaining yellow ligament, contralateral recess exposed and decompressed, dissector and navigation to assess adequacy of decompression until passes contralateral inferior pedicle, collagen-sponge soaked steroid applied to nerve roots, standard closure with local anesthetic
Complication avoidance Hemilaminectomy, thin bone with drill, lateral recess decompression Preservation of L3–4 facet, remove superior articulating facet to level of the pedicle of L5 to decompress lateral recess and foramen, TLIF on more symptomatic side, anterior placed TLIF MIS, preserving yellow ligaments, over-the-top technique for bilateral decompression MIS, surgical navigation, alternating drill bits, decompression of nerve root at shoulder, navigation to help assess decompression, over-the-top technique for bilateral decompression
Postoperative
Admission Floor Floor Outpatient Floor
Postop complications feared CSF leak Radiculopathy, infection, adjacent segment degeneration CSF leak, nerve root injury Inadequate decompression, nerve root injury, dural tear
Anticipated length of stay 1 day 2 days Same-day discharge 1–2 days
Follow-up testing Standing flexion-extension x-rays 4–6 weeks after surgery 36-inch standing films prior to discharge, 4 weeks, 3 months, 6 months, 1 year, 2 years after surgery None AP and lateral lumbar x-rays 6 months and then annually after surgery
Bracing None LSO for comfort None None
Follow-up visits 10 days after surgery 4 weeks, 3 months, 6 months, 1 year, 2 years after surgery 6 weeks after surgery 2 weeks, 1 month, 3 month, 6 months, annually after surgery
DEXA , Dual-energy x-ray absorptiometry; ERAS , enhanced recovery after surgery; ESI , epidural spinal injections; IOM , intraoperative monitoring; MIS , minimally invasive surgery; NSAID , nonsteroidal antiinflammatory drug; PSIS , posterior superior iliac spine.

The different types of spondylolisthesis include the following ( Table 1.2 ):

  • Congenital/dysplastic is a result of malformed facet joints. It predominately occurs in the lumbosacral junction. A malformed inferior facet joint may lead to enlongation of the facet joint, ultimately leading to a pars defect. Due to this congenital nature, it is commonly associated with spina bifida.

  • Isthmic is the most common form of spondylolisthesis and results from a defect of the pars interarticularis. This subtype is a result of repeated microfracture and remodeling of the pars. This is most common in young athletes who participate in high-impact sports.

  • Degenerative results from degeneration of the facet joint. Degeneration of the joint space causes abnormal motion. The remodeling that occurs as a result of degeneration causes a more sagittal alignment of the facet, which allows progression of the spondylolisthesis. This type is typically associated with both foraminal and canal stenosis.

  • Traumatic is the result of a fracture that typically does not involve the pars. Over time, slippage of the vertebral body occurs following the injury. This is unique in that healing can occur from simple immobilization. Fractures that are associated with an acute slippage are defined as a fracture dislocation and should be treated accordingly.

  • Pathological are grouped into two types: generalized and local. Generalized spondylolisthesis is caused by diseases such as Paget disease, hyperthyroidism, osteoporosis, and syphilitic changes. The localized subtype is due to local destruction from tumors and infection. Iatrogenic cause of pathological spondylolisthesis can also be classified as localized spondylolisthesis, although some authors have classified this as its own entity.

Table 1.2
Types of spondylolisthesis
Type Cause
Congenital/dysplastic Malformed inferior facet
Isthmic Defect of pars interarticularis
Degenerative Degeneration of facet
Traumatic Fracture that typically does not involve the pars
Pathological Paget disease, hyperthyroidism, osteoporosis, syphilitic changes, infection, and tumor

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