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Over the past 10–20 years there have been major improvements in blood safety in low and lower middle-income countries (LIC, LMIC), largely driven by the human immunodeficiency virus (HIV) epidemic. Unfortunately, improvements in blood supply adequacy have not been as marked, and many challenges to the provision of an adequate supply of safe blood in these countries remain, particularly in countries that have relied or still rely heavily on external funding. Indeed, these challenges could increase if external funding decreases without concomitant increase in country-based funding. This chapter reviews some of these challenges with particular reference to sub-Saharan Africa (SSA) outside of southern Africa, where most countries are LIC or LMIC.
Income groups referred to are those defined by the World Bank (LIC, LMIC, and high-income country [HIC] being countries with gross national income per capita in 2017–18 of ≤US$1005, US$1006–3995 and ≥US$12,236, respectively) and, unless stated otherwise, data concerning transfusion activities are taken from the World Health Organization (WHO) 2016 Global Status on Blood Safety and Availability (GDBS), which is based on data reported from 180 countries, primarily data collected in 2013.
WHO recommends that all activities related to blood collection, testing, processing, storage, and distribution be coordinated at the national level and governed by a national blood policy and legislative framework. In 2013, 79% of HIC and 41% of LIC reported having specific legislation covering safety and quality of blood transfusion. However, only 15 (33%) countries in Africa reported having a system of regular inspection of blood transfusion services by a national regulatory authority.
Whole blood (WB) donations/1000 population is an indicator of general blood availability. WHO has estimated that at least 10 donations/1000 population are required to adequately fulfill any country’s transfusion requirements. Median WB donation rate in HIC in 2013 was 32.1 donations/1000 population, whereas in LMIC it was 7.8 and LIC 4.6. Within WHO’s Africa region, 38 countries reported collecting <10 donations/1000 population—almost unchanged from the 2011 report when it was 39. A review published in 2008 concluded that 26% of in-hospital maternal deaths due to hemorrhage in SSA were directly due to lack of blood, and more recently a study of severely anemic children (Hb < 5 g/dL) found that, at 8 hours after admission, 52% (54/103) of children who had not received a transfusion versus 4% (39/899) who had received a transfusion died. Inadequate supply of blood remains one of the most pressing problems in LMIC and LIC.
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