Integrative Approaches to the Management of Patients with Heart Disease


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Integrative Cardiology

Integrative cardiology is a philosophy of care rather than a description of a discrete set of practices, with a particular focus on prevention of disease and an emphasis on patient well-being and personal agency. Completely inclusive of guideline-based medical therapy, integrative cardiology seeks to empower patients to the greatest degree possible with the collaborative development of health goals and therapeutic plans ( Fig. 34.1 ).

FIGURE 34.1, Key elements of an integrative cardiology approach.

Utilization of Additional Therapies

In addition to a strong emphasis on nutrition and lifestyle-based interventions, integrative cardiology includes therapeutic modalities not typically used in conventional cardiac care. Examples include interventions focused on the connection between the mind and heart (i.e., breathing exercises, meditation, biofeedback, and guided imagery), acupuncture, and a select group of evidence-based over-the-counter products.

Cardiologists in particular need to be aware of these therapies frequently utilized by cardiac patients—often without disclosure of their use. Data from the 2017 National Health Interview Survey of over 26,000 adults documented that 31.8% of surveyed individuals with cardiovascular disease have used at least one form of “complementary” medicine within the previous 12 months. The survey also found that patients who utilize complementary approaches do so as an adjunct rather than a replacement for conventional care—presumably to fill a gap perceived by the patient to be deficient or absent in usual care. Factors that predicted higher utilization of complementary therapies include female gender and higher levels of education, income, and health literacy.

Why Is Integrative Cardiology Important?

Integrative cardiology is important because it addresses unmet needs in conventional care.

A report from the Centers for Disease Control reveals that after years of consistent decline, the death rate from cardiovascular disease has begun to plateau. This ebb in progress, despite advances in pharmacologic and procedural therapeutics, is largely attributed to unchecked increases in the prevalence of obesity and diabetes—diseases largely preventable through dietary intervention.

Paradoxically, despite the high burden of cardiovascular diseases rooted in diet and lifestyle, nutrition remains poorly emphasized in cardiology training and practice. For example, in the current 56-page document from the Accreditation Council for Graduate Medical Education that contains very detailed procedural specifications for fellowship training in cardiovascular disease, there remains no requirement for nutrition education. Accordingly, a recent survey found that 90% of cardiologists reported receiving minimal or no nutrition education in their training. An integrative approach seeks to address this deficiency in both education and practice by highlighting nutrition and lifestyle as integral components of cardiac care.

One of the tenets of integrative cardiology is an emphasis on patient empowerment and shared decision making. Apart from the clear right of patients to determine their health priorities and goals, there is substantial evidence that patients who actively engage in decision making and self-care have greater insight into their condition and are more likely to adhere to a mutually agreed course of treatment. Recent Medicare policy has transformed shared decision making from a best practice to a payment necessity for select cardiac intervention, including implantation of cardioverter-defibrillators and left atrial appendage closure devices. Although likely fiscally driven initiatives, these policy changes are consistent with the patient-centered focus characteristic of integrative cardiology.

Associated Treatment Modalities

Nutrition

Nutritional interventions are a foundation of integrative cardiac care for both the prevention and treatment of cardiovascular disease (see Chapter 29 ). Although current guidelines for cardiac care emphasize the primacy of diet and lifestyle interventions, the data show that dietary counseling currently plays a minimal role in cardiology practice.

Mind/Body

In recognition of the strong influence of thoughts and emotional state on cardiovascular health, an integrative approach draws on this connection as a potential input for therapeutic intervention. In addition to the more traditional cognitive behavioral therapy and medication, modalities that might be recommended in an integrative model include meditation, breathing exercises, yoga, biofeedback, healing touch, and Reiki.

Acupuncture

Although acupuncture is most commonly used in the treatment of musculoskeletal pain, emerging data show promise for acupuncture to be used as adjunctive treatment for a range of cardiovascular conditions including hypertension.

Supplements/Botanicals

Integrative cardiology is open to the use of evidence-based supplements and botanicals, while rejecting those that have been disproven. Many physicians are understandably reluctant to consider the use of over-the-counter products, not only because of questions of efficacy, but also due to concerns regarding purity and safety. In recognition of these significant caveats, it is incumbent upon the cardiologist to be knowledgeable about the supplements most commonly used by cardiac patients and, most importantly, to be aware of trusted resources—as summarized in this chapter—that permit critical evaluation of the available science surrounding these compounds.

Although it is considered good medical practice to document all over-the-counter products taken by patients, this information has limited value if clinicians are unaware of the composition of these supplements and lack sufficient knowledge to credibly evaluate their potential benefits, risks, and interactions with medication.

Fortunately, several excellent resources are available to help clinicians learn about the science of supplements ( Table 34.1 ), including the National Institutes of Health (NIH) Office of Dietary Supplements ( http://ods.od.nih.gov ), and a service of the U.S. National Library of Medicine, MedlinePlus ( https://medlineplus.gov/druginfo/herb_All.html ). The Natural Medicines Database ( http://www.naturaldatabase.com/ ) is an independent group that provides an extensive fee-based literature review and assessment of the potential benefits and risks of a wide range of supplements. They also offer handouts to patients that summarize key facts in easy-to-understand language.

TABLE 34.1
Resources for Evaluation of Supplements

A valuable resource for clinicians to evaluate the chemical composition and purity of individual brands of supplements is ConsumerLab.com ( http://www.ConsumerLab.com ), a group that performs independent laboratory analyses on a wide range of commonly available products and offers detailed information on its web site for an annual fee. In addition, the scientific nonprofit US Pharmacopeial Convention has established quality standards recognized by a label that signifies compliance with these standards.

Need for Interprofessional Collaboration

Communication between cardiologists and allied health professionals, including those not typically associated with conventional medical care, has historically been challenging. Despite differences in language and perspectives, mutual respect and open communication between all health professionals, conventional and alternative, is essential for coordination of care and optimal outcomes.

Integrative Strategies for Specific Cardiac Conditions

The foundation of integrative cardiology is guideline-based therapy. In the following section, a select group of evidence-based approaches not often utilized in conventional management are described. These tools, added to guideline-based therapy, may extend its benefits, and provide additional opportunities to engage and empower patients.

Ischemic Heart Disease (See Chapter 40 )

Nutrition

A recent analysis reveals that fully 45% of all cardiometabolic deaths are diet-related. The foundational role of nutrition and lifestyle has been codified in the 2018 AHA/ACC Guideline on the Management of Blood Cholesterol, in which lifestyle interventions are positioned at the very apex of flowcharts for both primary and secondary prevention of atherosclerotic cardiovascular disease.

Among the components of a cardioprotective diet, green leafy vegetables (including spinach and kale) appear to be especially beneficial. Combined data from the Nurses’ Health Study and Health Professionals Follow-Up Study showed that each daily serving of green leafy vegetables significantly reduced the risk of coronary disease by 17% and ischemic stroke by 24%.

Anthocyanins are dietary flavonoids that enhance endothelial function and have antioxidant and antihypertensive properties. Foods rich in anthocyanins, especially blueberries and strawberries, are strongly linked to cardiac health. During an 18-year follow-up of the Nurses’ Health Study II that included 93,600 women, intake of four or more servings of blueberries and strawberries was associated with a 34% decreased risk of myocardial infarction.

Nut consumption has consistently been found to reduce the risk of heart disease and improve longevity. The health-promoting properties of nuts are likely related to their rich content of magnesium, sterols, Vitamin E, fiber, and both polyunsaturated and monounsaturated fats. In addition to these cardioprotective nutrients, newer data suggest nuts have the added benefit of antiinflammatory properties and a beneficial impact on the gut microbiome.

Mind/Heart Connection

There is no more vivid example of the connection between the mind and heart than Takotsubo syndrome, a condition of acute and severe left ventricular failure precipitated by psychological trauma (see Chapter 52). This syndrome is dramatic in its presentation and is one of the many manifestations of stress and emotional state on cardiac health. Not unexpectedly, the incidence of Takotsubo’s cardiomyopathy significantly increased during the COVID-19 pandemic.

Meditation

The link between mind and heart can be harnessed for prevention of ischemic heart disease. In a randomized, controlled study of meditation and conventional cardiac care in 201 individuals with coronary disease, the meditation group experienced a 48% (p= 0.025) reduced risk of a composite endpoint including all-cause mortality, myocardial infarction, and stroke. The underlying mechanism of benefit is unclear but likely includes a favorable effect on blood pressure with possible additional salutary influences on endothelial function and inflammation. In acknowledgment of the data that support the value of meditation, the American Heart Association issued a scientific statement on meditation and cardiovascular risk reduction that included “…meditation may be considered as an adjunct to guideline-directed cardiovascular risk reduction by those interested in this lifestyle modification…”.

Tai Chi

Tai Chi is an ancient practice that consists of a sequence of smooth, slow-paced movements with coordinated breathing, often referred to as a “meditation in motion.” Because Tai Chi incorporates aspects of both physical activity and stress reduction, it has been studied for reduction of cardiovascular events.

Recognizing that over 60% of eligible patients do not participate in cardiac rehabilitation, an alternative program utilizing Tai Chi has been evaluated for patients with coronary disease. In a study of patients with coronary disease who refused traditional cardiac rehabilitation, those who participated in an extended program of Tai Chi (6 months compared to 3 months), experienced greater weight loss and improved quality of life.

Supplements

Omega-3 (see also Chapters 25, 27, and 29)

A widely supported dietary recommendation is to consume at least two servings of omega-3 rich fish per week. Nevertheless, for those who cannot or choose not to eat fish, omega-3 supplements may be particularly beneficial. Several brands of prescription omega-3s are now available.

Over-the-counter fish oil supplements may also be prescribed, but dosing requires special attention. Many over-the-counter omega-3 supplements include a front-of-the-bottle label that describes total omega-3 content. The total omega-3 content can be misleading, as accurate dosing is dependent on docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) content, which may be only a fraction of the total omega-3 amount listed on the front label. If, for example, 1000 mg of combined DHA and EPA are prescribed, patients should be advised to review the back label of an over-the-counter omega-3 product and take as many pills as needed to total 1000 mg of combined DHA and EPA. Despite a front label indicating 1000 mg of fish oil per pill, some omega-3 preparations require 2 or 3 pills daily to total 1000 mg of combined DHA and EPA. Current trial evidence primarily supports prescription eicosapentaenoic acid to reduce major adverse cardiovascular events.

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