Achieving angiographic diagnosis


Having a high-quality route map of the target vascular bed and, if necessary, the access to it are the keys to successful vascular intervention. They determine the choice of approach, the best equipment to use and the suitability for intervention. A preliminary diagnostic angiogram is seldom now required and non-invasive diagnostic imaging using ultrasound (US), magnetic resonance angiography (MRA) and computed tomography angiography (CTA) is the norm. Therapeutic decisions and approach are planned on this basis.

The skills necessary to perform high-quality angiography are still mandatory as digital subtraction angiography (DSA) is required in the following contexts:

  • Intervention

  • When small-vessel detail is required

  • Where non-invasive imaging has failed or cannot be tolerated

  • To arbitrate when non-invasive imaging is not conclusive and a definitive answer is needed.

Diagnostic digital subtraction angiography

Obtaining good-quality diagnostic angiograms is central to any successful endovascular intervention, remember to apply the basic principles of angiography ( Ch. 29 ) and catheterization ( Ch. 30 ).

This chapter details the indications, equipment, procedural details and views for all the common sites. If a pump injection is recommended, then we have assumed 300 mg/mL-strength iodine will be used. When hand injections are recommended, 300 mg/mL is too viscous for rapid injection and we would suggest dilution with saline to approximately 200 mg/mL.

Lower limb arterial diagnosis

Imaging the lower limb arteries is most frequently requested to investigate chronic ischaemia (intermittent claudication, rest pain and ulceration) or acute ischaemia ( Fig. 45.1 ). Less common reasons are trauma, vascular malformation and tumour. The choice of imaging modality and the study should be tailored to obtain the information necessary for the clinical scenario ( Table 45.1 ). A standard peripheral angiogram covers from the infrarenal abdominal aorta to the ankle ( Table 45.2 ). Lateral foot views are mandatory if distal intervention for critical limb ischaemia is being considered.

Fig. 45.1, Typical appearance of an embolus (black arrow) involving the bifurcation of the common femoral artery. The filling defect has a convex meniscus and is sited at a bifurcation. The underlying artery is normal and there are no collaterals.

Table 45.1
Lower limb arterial imaging depends on the clinical scenario
Scenario Modality
Elective
Intermittent claudication MRA > CTA > Ultrasound a > DSA
Chronic critical limb ischaemia MRA > CTA > DSA
Assessment of bypass graft Ultrasound diagnosis then DSA for intervention
Popliteal aneurysm Ultrasound for diagnosis and size, MRA for inflow/outflow
Popliteal entrapment Ultrasound initial diagnosis, MR/MRA for delineation of type
Tumour/vascular malformation Ultrasound for flow (high or low), MRI for extent, angiography for intervention
Acute
Acute limb ischaemia CTA/MRA, DSA depending on availability and expertise
Trauma CECT for vascular and nonvascular injury, DSA for intervention

a Ultrasound can be used to perform a basic screen of the femoropopliteal segment but this does not answer issues regarding inflow and outflow, hence MRA is the preferred tool due to speed and increased coverage.

Table 45.2
Typical parameters for a lower limb angiogram
View Contrast volume (mL) Injection rate (mL/s) Frame rate (FPS) Field size (cm) Inject delay (s) X-ray delay (s)
AP aorto-iliac 15 8 2 40 1.5 0
Oblique aorto-iliac 15 8 2 28 1.5 0
AP proximal thigh 10 5 2 40 0 0
AP distal thigh 10–15 5 1 40 0 Increase as necessary
AP calf vessels 10–20 5 1 40 0 Increase as necessary
Lateral foot 10–20 5 1 28 0 Increase as necessary
AP, anteroposterior; FPS, frames per second.

Equipment

  • Basic angiography set

  • Catheter: pigtail or straight, 3F 30-cm length, 4F 60-cm, 90-cm or 120-cm (femoral, brachial and radial approach, respectively). Always use the femoral route unless contraindicated.

Procedure

Access:

Tailor to the planned intervention. Diagnostic angiography for peripheral vascular disease is traditionally performed from the symptomatic leg unless the femoral pulse is absent or very weak. This ensures optimal images of the affected side. Straight catheters can be pulled back into the external iliac artery for single-leg views. There is no risk to the asymptomatic limb.

Catheterization:

Position the catheter below the renal arteries.

Runs:

Tailor the examination to the individual patient.

Supplemental views:

Additional views are frequently required pre- and post-intervention or in the presence of prosthetic joints; the answer is almost always an alternative projection, either an oblique view or a lateral. Adjunctive manoeuvres, such as flexion of the contralateral leg in a patient with a knee joint prosthesis, will help achieve an unimpeded lateral view ( Fig. 45.2 ).

Tip

Remember the diagnostic maxim: one view is one view too few. We are trying to visualize 3D structures. If in doubt, try another run at 90 degrees to the original.

Fig. 45.2, High-grade stenosis behind a knee prosthesis (white arrow) seen on the lateral knee view. This was not seen on AP or shallower obliques.

Iliac obliques

The iliac vessels are tortuous and oblique views are essential to allow full assessment before and after intervention and also to demonstrate the origins of the internal iliac arteries in profile.

Tip

Remember to use the contralateral oblique view, e.g. LAO for the right iliac system.

Profunda oblique

To see the origins of the profunda femoris artery (PFA), superficial femoral artery (SFA) and femoropopliteal/distal grafts, i.e. right anterior oblique (RAO) 30–50 degrees for the right PFA.

Focal stenoses

Any stenosis can be more accurately assessed if an additional oblique view is taken. Experiment with 30 degree obliques in either direction to try to profile the lesion.

Lateral foot views

Both feet – the ‘Charlie Chaplin’ – place both heels together, turn toes out, 40-cm field.

Single foot – externally rotate the foot and rotate C-arm the opposite way to obtain lateral projection, 28-cm field.

Troubleshooting

Poor views of the distal run-off, this is usually the result of slow flow, contrast dilution and movement:

  • Increase the volume and strength of contrast delivered

  • Collimate to a single limb

  • In the ipsilateral limb, pull back a straight, multi-sidehole catheter into the external iliac artery (EIA) to direct all of the contrast to the area of interest

  • In the contralateral limb, use a shaped catheter (e.g. Cobra II or RDC) to catheterize the contralateral EIA

  • Use a vasodilator such as tolazoline or glyceryl trinitrate (GTN) to increase flow.

Tip

Use iso-osmolar contrast in patients with critical ischaemia. This reduces the pain/heat associated with contrast injection. Everyone is happy, the patient stays still, you save time and improve your images!

Arterial bypass graft imaging

Imaging aims to demonstrate mechanical problems:

  • Anastomotic stenoses caused by neointimal hyperplasia. Usually within the first year

  • Intragraft stenosis, particularly at valve cusps and in composite vein grafts

  • Progression of disease in the arterial inflow or outflow. Usually after the first year

  • Graft kinking during knee flexion. This should always be excluded following thrombolysis if no other abnormality is found ( Fig. 45.3 ). The graft usually kinks a few centimetres above the knee joint; this is best appreciated in the lateral projection.

    Fig. 45.3, Following thrombolysis, lateral views with the knee straight (A) and flexed (B) reveal kinking (arrows) as the underlying problem.

Arterial bypass graft DSA

Graft angiography can be difficult due to scarring over the femoral arteries and limited access. Success is much more likely if you spend time ascertaining the graft anatomy, material and the results of the Duplex ultrasound before you start. Give prophylactic antibiotics when puncturing synthetic grafts, e.g. cefuroxime 750 mg IV.

Equipment

  • Basic angiography set.

Procedure

Access:

Use ultrasound guidance to target puncture, use Table 45.3 as a guideline for choosing the point of access.

Table 45.3
Access sites for graft angiography
Graft configuration Angiography approach Intervention approach Tips
Axillofemoral Radial or brachial Brachial for proximal lesions graft or CFA for distal problems
Aortofemoral CFA or brachial CFA or brachial
Iliofemoral crossover Donor side CFA Either CFA Steep angulation at origin, establish access with Amplatz wire, then introduce long sheath or guide-catheter for support
Femoro-femoral crossover Donor CFA Either CFA or graft
Femoro-popliteal/distal Antegrade CFA Antegrade CFA for distal problem, retrograde for inflow Cobra or RDC useful to access graft origin

Catheterization:

The majority of at-risk grafts will be infra-inguinal, and antegrade puncture is usually required. Most grafts come off the common femoral artery (CFA) anteriorly and steep ipsilateral anterior oblique views are useful to profile their origins and to guide selective catheterization ( Fig. 45.4 ).

Fig. 45.4, Oblique view showing non-occlusive thrombus in the profunda femoris artery (black arrows) and origin of the femoropopliteal vein graft. The stump of the native SFA (arrowhead) lies in between.

Runs:

A satisfactory angiogram must show the graft inflow and run-off and include views of the proximal and distal anastomoses in profile ( Figs. 45.4 and 45.5 ). Magnified oblique views should be used to demonstrate stenoses. When imaging vein grafts, demonstration of contrast jetting as a result of valve cusps requires runs at 6 frames per second (FPS). These should be viewed with a wide contrast window ( Fig. 45.6 ).

Tip

The Doppler is right! If the lesion cannot be identified at angiography, wheel in an ultrasound machine and re-scan to mark the lesion.

Fig. 45.5, Profile view of the distal cuff of a below-knee femoropopliteal vein graft. The popliteal artery is diffusely narrowed below the graft.

Fig. 45.6, A valve cusp (arrows) that was causing significant stenosis in a vein graft.

Troubleshooting

Difficulty inserting the sheath:

Review the basic principles of vascular access.

Difficulty catheterizing the graft origin

Once you have chosen the optimal projection, use roadmap or fluoroscopy fade for guidance. A shaped catheter, usually a Berenstein, Cobra or RDC, can be directed towards the graft origin.

Difficulty visualizing the graft origin

Contrast in the CFA patch, the stump of the SFA or in the PFA may obscure the graft origin. Position the catheter with its tip in the proximal graft; contrast can then be refluxed to show the graft origin. A frame rate of ≥2 FPS is necessary. Laterally running grafts are best shown with the ipsilateral posterior oblique view.

Upper limb arterial diagnosis

Upper limb ischaemia represents only 4% of peripheral vascular disease and is not as frequently associated with generalized atherosclerosis as lower limb ischaemia. Disease is usually focal, affecting the origins of the great vessels. In thoracic outlet syndrome (TOS), vascular compression by bone or ligament is associated with distal embolization, Raynaud's syndrome and subclavian aneurysm. Imaging depends on the clinical scenario ( Table 45.4 ).

Alarm

Arch aortography and selective catheterization of the great vessels carry a risk of stroke, so particular care must be taken during catheter and wire manipulation and catheter flushing. Never flush a blocked catheter in the aortic arch.

Table 45.4
Upper limb arterial imaging depends on the clinical scenario
Scenario Modality
Elective
Chronic upper limb ischaemia MRA a > CTA > ultrasound; DSA for intervention. Vasodilator may be required to differentiate spasm from fixed lesions in digital arteries. MRA can be combined with oral vasodilator and DSA with intra-arterial vasodilator
Thoracic outlet syndrome Ultrasound with postural manoeuvres as initial screen. MRA using blood pool agent and postural manoeuvres subsequently
Acute
Acute limb ischaemia CTA, MRA, DSA depending on availability and expertise
Trauma/dissection CTA for vascular and non-vascular injury, DSA for intervention
Ultrasound does not demonstrate origins of the great vessels.

a Dedicated MRA is needed for the hand vessels.

Equipment

  • Basic angiography set

  • Catheters: 90-cm 4F pigtail, Berenstein, Headhunter, Sidewinder

  • Guidewires: angled hydrophilic guidewire

  • GTN or other vasodilator.

Procedure

Access:

Diagnostic angiography is usually performed from the femoral approach. Therapeutic intervention is often easier from the brachial artery or with combined femoral and brachial access.

Catheterization:

Use a pigtail catheter for arch aortography. A Berenstein catheter will engage the vast majority of arch vessels if used properly.

Runs:

Begin with an arch aortogram to show the origins of the great vessels. Additional views may be needed to show the proximal subclavian arteries, particularly when they are tortuous. In suspected TOS, perform runs with the arms raised above the head and also in the Roos position (elbow flexed 90 degrees, shoulder abducted 90 degrees and dorsiflexed). It is possible to see as far as the elbow from an arch injection; a selective catheter should be advanced peripherally to image the distal arm vessels. Use iso-osmolar contrast when imaging the digital arteries. Remember that the radial and ulnar arteries often arise from the axillary or brachial arteries; failure to recognize this will lead to misinterpretation.

Tip

To obtain high-quality images of the digital arteries, invert the C-arm and place the hand on the image intensifier, immobilizing it with a sandbag. Use a vasodilator to increase flow and discriminate fixed lesions from spasm ( Fig. 45.7 ).

Fig. 45.7, ‘Blue digit syndrome’.

Interpretation

Vascular compression during postural manoeuvres also occurs in about 30% of normal subjects; subclavian artery irregularity or aneurysm is a more valuable sign of TOS ( Fig. 45.8 ). Diffuse atheroma affecting the subclavian and axillary arteries is most commonly caused by radiotherapy. A proximal high-grade stenosis or occlusion may cause a subclavian steal; this is usually asymptomatic. You should expect reversed flow in the vertebral artery from the duplex; if not, it will only be seen on late images from the arch aortogram.

Fig. 45.8, Thoracic outlet stenosis presenting with distal embolization.

Troubleshooting

Unable to catheterize an arch vessel

  • Remember the basic rules; identify the target vessel on an overview.

  • If the arch is unfolded, the Berenstein catheter may be difficult to control; try using a Headhunter 1 catheter, which has a wider primary curve.

  • If the target vessel is angulated backwards, then a reverse curve catheter, such as a Sidewinder may be helpful.

Poor visualization of the distal vessels

  • Use a vasodilator to increase flow and also to discriminate spasm from irreversible fibrosis.

  • Use iso-osmolar contrast and try increased contrast strength.

  • Selectively catheterize and advance the catheter into a peripheral position.

Aortic arch arterial diagnosis

CTA and MRA have almost completely replaced DSA in the investigation of patients with aortic syndromes, penetrating ulcer, dissection, intramural haematoma and traumatic injury.

Aortic arch DSA. Paradoxically, arch angiography has become more frequent in the context of thoracic aortic stent grafting and carotid artery intervention ( Fig. 45.9 ).

Fig. 45.9, (A,B) AP projections from arch aortogram and MRA showing calcified plaque causing innominate (arrowhead) and left CCA (arrows) stenosis. (C) LAO 30 degree projection gives a better view of the final line arch morphology and the left CCA (arrow) but obscures the innominate.

Equipment

  • Basic angiography set

  • Catheter: 90-cm 4F or 5F pigtail.

Procedure

Catheterization:

Position the pigtail catheter in the ascending aorta just above the aortic valve.

Runs:

A 30 degree LAO to show aortic arch and origin of the great vessels (centre on the aortic arch); a 60 degree LAO may be helpful during stent grafting and in trauma cases ( Table 45.5 ).

Table 45.5
Suggested runs for arch aortography
View Contrast volume (mL) Injection rate (mL/s) Frame rate (FPS) Field size (cm)
LAO 30 degrees, LAO 60 degrees AP 40 18–25 2–4 28–40

Interpretation

Look for irregularity in the lumen in the region of the ligamentum arteriosum as this is the usual site of injury ( Fig. 45.10 ). A ductus bump appears as a smooth bulge only on the inner curvature.

Fig. 45.10, Aortic trauma: the chest X-ray showed mediastinal widening.

Renal arterial imaging

Renal arterial imaging is needed in four groups of patients:

  • Those with renal vascular pathology

  • Those with renal transplants

  • Potential live renal donors

  • Patients with renal tumours requiring embolization.

Magnetic resonance and CT angiography have largely replaced diagnostic renal angiography. DSA remains the ‘gold standard’ and is still required in case of doubt or to demonstrate distal disease such as fibromuscular dysplasia (FMD) ( Fig. 45.11 ). Renal arterial imaging is most frequently requested to investigate renal artery stenosis (RAS), even though the benefit of renal revascularization is questionable except in renal transplants. The remainder of referrals are for trauma, tumour, pre-transplantation assessment or, rarely, arteritis ( Table 45.6 ).

Fig. 45.11, Multifocal renal artery stenosis.

Table 45.6
Renal arterial imaging depends on the clinical scenario
Scenario Modality
Elective
Renal artery stenosis MRA a , DSA for intervention and for detail of small vessels
Live renal donor assessment MRA, CTA, including venous and ureteric phases. DSA if any doubt. Note: radiation dose issue with CTA in a healthy patient
Renal tumour embolization Check the contralateral kidney and plan approach on CT/MRA
Renal artery aneurysm CTA or MRA for roadmap and assessment
Acute
Trauma/bleeding CTA for vascular and nonvascular injury, DSA for intervention

a MRA is unable to exclude subtle lesions of FMD.

Renal artery DSA

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