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High-Grade Serous Carcinoma with “SET” Patterns


D efinition — A distinctive constellation of patterns (solid, endometrioid-like, and transitional [SET]). Defined (arbitrarily) as greater than 50% of the tumor.

Clinical Features

Epidemiology

  • Frequently associated with BRCA1 or BRCA2 germline mutation (approximately 50%).

  • This pattern is seen less frequently (about 25%) in sporadic serous carcinomas, and may be associated with somatic mutations in BRCA1 or BRCA2 .

  • Younger mean age than classic serous carcinomas.

  • Lower frequency of associated serous tubal intraepithelial carcinoma than classic serous carcinoma.

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