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Key Points Salivary gland malignancies are diverse and heterogeneous. Their behavior and resulting clinical management are highly dependent on their histologic type and, often, their grade. High-grade histologic types include high-grade mucoepidermoid carcinoma, squamous cell carcinoma, undifferentiated carcinoma, high-grade adenocarcinoma…
▪ Squamous Cell Carcinoma Squamous cell carcinoma (SCC) arises not only from the surface epithelium of the oropharynx but also from the tonsillar crypts. It is steadily increasing in incidence due to high-risk human papillomavirus (HPV), and HPV-positive oropharyngeal SCC…