Overview of pulmonary hypertension Definition and Nomenclature Pulmonary hypertension (PH) is defined classically as a sustained mean pulmonary arterial blood pressure (mPAP) ≥ 25 mm Hg measured in the supine position by right heart catheterization. The PH clinical syndrome typically…
Acute aortic dissection is an uncommon but life-threatening emergency that requires prompt diagnosis, rapid triage, and immediate treatment. A unified effort across several international centers over the past 20 years has resulted in the establishment of a detailed, prospective registry…
Fibrosis refers to the reorganization of loose extracellular matrix (ECM) and proliferation of fibroblasts that causes connective tissue thickening. Upregulation of profibrotic signaling pathways occurs in response to tissue destruction as a compensatory mechanism when parenchymal cells are unable to…
Acknowledgments Dr. Maron would like to acknowledge Dr. Stuart Rich, who authored an earlier version of this chapter which inspired many young physicians and students including Dr. Maron to pursue pulmonary hypertension in clinical and research endeavors. Dr. Maron reports…